Read the latest news from the Bluhm Cardiovascular Institute's (BCVI) Clinical Trials Unit (CTU) of Northwestern. The links below take you to information about the BCVI’s recent discoveries and successes, and faculty achievements and honors.
Electric shocks delivered by subcutaneous defibrillators are equally effective compared to shocks delivered by conventional transvenous defibrillators, according to a recent study.
Statin therapy has been shown cost-effective for lowering cholesterol in young adults, according to a study published in the Journal of the American College of Cardiology.
Dapagliflozin, a drug commonly used to treat type 2 diabetes, improved heart failure-related symptoms and physical limitations in patients with heart failure with preserved ejection fraction.
Valsartan, an angiotensin II receptor blocker drug, delayed disease progression and improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy, according to a recent clinical trial.
Donald Lloyd-Jones, MD, ScM, chair of Preventive Medicine and the Eileen M. Foell Professor of Heart Research, and current president of the American Heart Association, recently testified before Congress in support of legislation that would improve cardiovascular health in the U.S.
A machine learning model can identify patients at risk of a rare cardiomyopathy, according to a recent study.
Epigenetic aging could serve as a promising biomarker for measuring long-term cardiovascular health and disease risk, according to a recent Northwestern Medicine study.
Genomic autopsy of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy.
Inefficient cardiac repair after heart attacks is partially driven by a maladapted response to a low oxygen environment by immune cells, according to a study published in the Journal of Experimental Medicine.
Thirty-five years since it was started, the Coronary Artery Risk Development in Young Adults study, or CARDIA, has become a premier source for the determinants, mechanism and outcomes of cardiovascular disease and manifestations of aging.
Risk factors such as hypertension, diabetes and smoking conferred greater risk of heart failure in young and middle aged individuals when compared with older individuals, according to a recent study.
Donald Lloyd-Jones, MD, ScM, the Eileen M. Foell Professor and chair of Preventive Medicine, is the newly elected president of the American Heart Association.
Scientists have developed the first-ever transient pacemaker — a wireless, battery-free, fully implantable pacing device that disappears after it’s no longer needed.
One of the biggest diseases of the modern era is a pernicious cluster of risk factors called metabolic syndrome, and Northwestern scientists across disciplines are looking for new ways to understand, target, treat, and even prevent this syndrome, with the hopes of ultimately creating a much healthier nation.
Northwestern Medicine scientists and clinicians have continued to investigate methods to combat the disease, including strategies to conduct clinical trials during a pandemic, studying neurologic symptoms in children and reflecting on the importance of professional medical organizations during a public health crisis.
A Northwestern Medicine study has shown that a high-intensity home-based walking exercise program improved walking ability in people with peripheral artery disease.
The AXL immune cell receptor has been linked to cardiac allograft vasculopathy, a thickening of vessel walls in transplanted hearts years after implantation, according to a recent study.
A team of Northwestern Medicine investigators have identified specific genetic regions that regulate the expression of genes associated with inherited cardiomyopathy and disease severity.
Inhibiting an inflammatory pathway reduced heart attack-induced damage in experimental models, according to a recent Northwestern Medicine study.
A mother’s heart health while she is pregnant may have a significant impact on her child’s cardiovascular health in early adolescence, according to a new study from Northwestern and Lurie Children's Hospital.
Northwestern Medicine investigators have discovered a potential multi-faceted therapeutic target for preventing and treating the metabolic syndrome, according to a recent study.
A new class of drugs shows benefit for both cardiovascular and kidney conditions, but scientists should be cautious in designing trials that include both cardiovascular and kidney outcomes in the same analysis, according to a Northwestern Medicine review article.
Using proxy measures of preparedness for hypertension or diabetes care did not accurately assess the ability of low- and middle-income countries to treat patients, according to a study published in PLOS Medicine.
A signaling molecule produced by the lymphatic vasculature could be used to promote cardiac repair after heart attack, according to a Northwestern Medicine study published in Nature.
A gene mutation discovered in a small Amish community in Indiana has inspired the use of a new experimental drug for COVID-19 that reduces blood clotting.
In late March, the world came to a virtual standstill. The COVID-19 pandemic forced leaders around the world to limit large gatherings and shutter schools and businesses. For Feinberg’s research enterprise, this was a serious disruption — but science kept moving forward.
The presence of inflammatory proteins was associated with comorbidity burden and deteriorating heart function in patients with heart failure with preserved ejection fraction, according to a Northwestern Medicine study.
Feinberg investigators are breaking down the mechanisms of aging and designing solutions to extend healthy living.
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
Starting cholesterol-lowering treatment earlier may increase the its benefits, reducing heart attack and stroke over time, according to a Northwestern Medicine study.