News and Announcements

Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.

Northwestern Medicine scientists have discovered new insights into the production and regulation of an emerging class of noncoding RNAs in three major types of cancer, according to findings published in Science Advances.

An international team of investigators have discovered that oligodendrocytes contribute approximately one-third of plaque formation alongside neurons in mouse models of Alzheimer’s disease, according to a recent study published in Nature Neuroscience.

Northwestern Medicine scientists have developed a new technique to identify individual cells for RNA sequencing, which will empower scientists to gather more accurate and precise scientific data, according to details published in Cell Genomics.

Northwestern Medicine investigators have discovered novel protein mechanisms that promote the rapid spread of Vibrio vulnificus, a rare but lethal bacteria that can cause vibriosis and sepsis, according to findings published in Proceedings of the National Academy of Sciences.

Northwestern Medicine investigators led by Derek Walsh, PhD, have discovered how poxviruses disarm and evade mitochondrial-driven antiviral responses for their replication in host cells, according to findings published in Nature Communications.

Northwestern Medicine investigators have identified novel genetic mechanisms that regulate blood vessel growth in the retina and may also serve as therapeutic targets for retinal vascular disease, according to findings published in Nature Communications.

Northwestern Medicine scientists have been awarded $17 million to study genetic causes of autism and schizophrenia, with the aim of developing new drugs to treat the conditions.

An international team of investigators have discovered that oligodendrocytes contribute approximately one-third of plaque formation alongside neurons in mouse models of Alzheimer’s disease, according to a recent study published in Nature Neuroscience.

Northwestern investigators have identified a novel transcription factor which regulates a signaling mechanism utilized by a fertilized embryo to protect its mother from cellular and environmental stress, according to a recent study to published in the journal Genes and Development.