Skip to main content
Northwestern University Feinberg School of Medicine
Basic Science Administration
Skip to main content

Events

Jan

31

"Functional Architecture and Neuromodulation of Thalamo-cortico-striatal Circuits"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Tianyi Mao, Ph.D. I plan to discuss our progress in understanding the neuronal connectivity between the cortex, thalamus, and striatum, which are essential for sensation, motor control, decision making, and reward. By using whole brain imaging combined with novel computational algorithms, we have established the comprehensive connectivity diagrams for the mouse thalamo-cortico-striatal pathways at the mesoscopic scale. Based on these connectomic maps, we have established quantitative descriptions of the subdivisions in the thalamus and striatum, and have identified novel functional domains. Functional studies revealed that the organization of thalamo-cortico-striatal circuits are both cell type- and subregion-dependent. I will also present our on-going work on the neuromodulation of the thalamo-cortico-striatal circuits by norepinephrine, dopamine and opioids using novel imaging modality we recently established.

more

Feb

03

Pharmacology Research Works-in-Progress: Tony Copeland-Hardin and Vladimir Jovasevic, PhD

Chicago - 4:00 PM - 5:00 PM

Please join the Department of Pharmacology for a Works-in-Progress presentations Tony Copeland-Hardin PhD Candidate in the Laboratory of Jennifer Kearney, PhD Characterization of Gene Modifiers in a Mouse Model of Epilepsy Dravet syndrome is a severe infant-onset epilepsy caused by loss-of-function variants in SCN1A, encoding the Nav1.1 voltage-gated sodium channel α-subunit. Individuals with the same SCN1A variant differ in clinical severity, suggesting that additional genetic modifiers likely influence penetrance and expressivity of the primary mutation. Mice with heterozygous deletion of Scn1a recapitulate features of Dravet syndrome. Phenotype severity varies on different mouse strain backgrounds, and we mapped several strain-dependent modifier loci. We are investigating candidate microRNAs as modifier genes that may mediate the strain-dependent severity in the Scn1a+/- mouse model. The contribution of microRNAs in Dravet syndrome is largely unexplored; however, microRNAs may serve as potent therapeutic targets. Vladimir Jovasevic, PhD Research Assistant Professor, Department of Pharmacology Cytoskeletal Gene Expression During Formation of Stress-Related Memories Stressful experiences are usually remembered vividly for long periods of time, as found in PTSD, but sometimes result in memories that are difficult to access, as it is in the case of dissociative amnesia. We set out to determine, using mouse behavioral models, whether accessible and memories with restricted access differ in their consolidation mechanisms. Specifically, we focused on early protein modifications and delayed expression patterns of cytoskeleton-associated genes. Our findings demonstrate that the expression of cytoskeleton-associated genes remains highly dynamic even at remote time points, with increasingly diverging gene expression profiles of accessible and memories with restricted access.        

more

Feb

04

Tina Mantis Lecture in Cancer Research | Interferon Signaling in Malignancies: Intracellular Immune Checkpoints as Novel Therapeutic Targets

Chicago - 11:30 AM - 12:30 PM

The Basic Research Seminar Series of the Robert H. Lurie Comprehensive Cancer of Northwestern University presents: TINA MANTIS LECTURE IN CANCER RESEARCH Interferon Signaling in Malignancies: Intracellular Immune Checkpoints as Novel Therapeutic Targets Leonidas C. Platanias, MD, PhD Director, Robert H. Lurie Comprehensive Cancer Center Jesse, Sara, Andrew, Abigail, Benjamin and Elizabeth Lurie Professor of Oncology Professor of Medicine (Hematology and Oncology) and Biochemistry and Molecular Genetics Northwestern University Feinberg School of Medicine Light lunch provided. The Tina Mantis Lecture in Cancer Research was established by the Lurie Cancer Center to honor the memory of Tina Mantis, an active supporter of the Hippocratic Cancer Research Foundation’s Founding Board, in recognition of her unwavering commitment and support in the fight against cancer.

more

Feb

04

Department of Microbiology-Immunology: Keara Lane, PhD

Chicago - 12:00 PM - 1:00 PM

Title: How Single Cells Make Decisions During Infection: Lessons from Innate Immune Signaling Speaker: Keara Lane, PhD / Northwestern University Host: Nicholas Cianciotto, PhD Topic: Bacterial infections are dynamic and heterogeneous, yet the bulk of our understanding of infectious disease has come from static, population-level measurements. What if we could just watch host and pathogen responses in individual cells as an infection progresses – what would we learn about infection? The Lane lab is focused on developing tools and approaches to explore the time dimension, or dynamics, of bacterial infection in individual cells. The lab uses live-cell imaging to determine how decisions made in individual host and bacterial cells influence infection outcome, with a view to identifying novel strategies to engineer cellular behavior to control infection outcome. 

more

Feb

05

CDB Seminar Series: Social signals and neuronal circuits that regulate development and aging

Chicago - 12:00 PM - 1:00 PM

  CDB SEMINAR PRESENTATION: Social Signals and Neuronal Circuits that Regulate Development and Aging   Ilya Ruvinsky, Ph.D. Research Associate Professor Department of Molecular Biosciences, Northwestern University     Wednesday, February 5, 2020 12:00 – 1:00 p.m. Ward 5-230, PHYSIOLOGY CONFERENCE ROOM 303 E. Chicago St Chicago, Illinois     Coffee and cookies served promptly at 12:00pm   Abstract Animals exchange social signals that shape aspects of development, disease, and aging, yet the underlying mechanisms remain poorly understood. We study these processes in C. elegans because the compact nervous system of this animal permits analysis of the underlying neuroendocrine circuits with great facility and precision. Our results reveal conserved mechanisms by which the nervous system modulates somatic and germline development and highlight the importance of regulatory crosstalk between neurons and peripheral organs. Finally, I will discuss our progress in converting the mechanistic insights we gained thus far into developing pharmacological interventions that prolong health span and delay senescence.   Host: Dr. Volodya Gelfand Professor, Department of Cell and Developmental Biology  Northwestern University, Feinberg School of Medicine            For more information please contact Vanessa Gonzalez, vanessa.g@northwestern.edu      

more

Feb

06

BMG Seminar: Ira Hall, PhD

Chicago - 10:00 AM - 11:00 AM

Ira Hall, PhD Associate Professor of Medicine, McDonnell Genome Institute (MGI) Washington University School of Medicine in St. Louis

more

Feb

06

"What do Mitochondrial Patients tell us about Parkinson's disease?"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Amy Reeve, Ph.D. Abstract Mitochondrial dysfunction is believed to be a key player in the pathogenesis of Parkinson’s disease, through its contribution to the degeneration of dopaminergic neurons. However, defects within this organelle are also detected in the same neurons, in normal ageing and mitochondrial diseases. However, mitochondrial dysfunction not always associated with significant neurodegeneration in these cases. Thus, we are interested in understanding how neurons respond to accumulating mitochondrial dysfunction, and whether such adaptive capabilities may be lost in Parkinson’s. In this seminar, I will discuss our work using post mortem brain tissue, as we aim to determine what differs between the response of dopaminergic neurons to mitochondrial dysfunction in Parkinson’s compared to the mitochondrial diseases. I will also present new data from imaging mass cytometry, with which we can understand the intricate relationships between mitochondrial protein expression in single neurons.

more

Feb

07

"Modulation of Neurotransmitter Release - Synaptic Integration in the Presynaptic Terminal"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Simon Alford, Ph.D. Abstract Presynaptic Gi/o-coupled receptors cause decreased neurotransmission, an important control mechanism and I will argue, a critical component of synaptic integration. Mechanisms for fast membrane-delimited inhibition of secretion may work through voltage-dependent Ca2+channels (VDCCs). However, a direct interaction between Gβγ and SNARE proteins also inhibits exocytosis downstream of Ca2+ entry. This mechanism directly controls evoked release, leaving secondary effects of presynaptic Ca2+ unaffected, but also can modify components of exocytosis not available to mechanisms that control release probability. These include modifying neurotransmitter released by interacting with a region of the SNARE complex that controls fusion rate, and modifying spontaneous release. The same synapses have different Gi/o-GPCR-triggered modulation of neurotransmitter release by different mechanisms. In hippocampal neurons, GABAB receptors decrease calcium entry and 5HT1b receptors inhibit exocytosis by acting on SNAREs at the same synapse: this allows for presynaptic neural integration. Our understanding of the physiological role of Gβγ-SNARE interaction has lagged because of a lack of tools. But recent progress in understanding the molecular basis of this interaction, in particular a target for Gβγ on SNAP25 has yielded a transgenic SNAP25Δ3 mouse with a selectively disturbed Gβγ-SNARE interaction. This mouse has normal evoked exocytosis and normal inhibition of VDCC, but disturbed inhibition of exocytosis through Gβγ-SNARE interaction. This mouse provides clear evidence that the Gβγ-SNARE locus is physiologically important for regulation, because it has a number of interesting phenotypes both central and peripheral, including elevated stress-induced hyperthermia, impaired supraspinal nociception, defective spatial learning, impaired gait, and depressive-like behavior. Most interestingly, two-mediated inhibitory mechanisms, co-occurring at the same synapse, are synergistic. Thus, perhaps combinations of neurotransmitters may shape neuromodulation, giving rise to novel effects on circuits and presynaptic integration. It raises the possibility that therapeutic pairing of drugs that affect each mechanism may themselves work synergistically, an exciting possibility.

more

Feb

10

Pharmacology Research Works-in-Progress: Rokana Taftaf and Rummi Ganguly

Chicago - 4:00 PM - 5:00 PM

Please join the Department of Pharmacology for a Works-in-Progress presentations Rokana Taftaf PhD Candidate in the Laboratory of Huiping Liu, MD, PhD Rummi Ganguly PhD Candidate in the Laboratory of Alfred George, MD            

more

Feb

11

Basic Research Seminar: Insights into the Metabolic Control of Hematopoietic Stem Cell Fate

Chicago - 11:30 AM - 12:30 PM

The Basic Research Seminar Series of the Robert H. Lurie Comprehensive Cancer of Northwestern University presents: Insights into the Metabolic Control of Hematopoietic Stem Cell Fate Keisuke Ito, MD, PhD Assistant Professor Department of Cell Biology Albert Einstein College of Medicine Light lunch provided. The Basic Research Seminar series presents prominent basic science speakers weekly to inspire and promote ongoing cancer research at Northwestern University.

more

Feb

12

CDB Seminar Series - Ajit Joglekar, PhD

Chicago - 12:00 PM - 1:00 PM

  CDB SEMINAR PRESENTATION: Engineering new assays to reveal the biological design of chromosome segregation machinery   Ajit P. Joglekar, Ph.D. Associate Professor Cell and Developmental Biology, University of Michigan Medical School     Wednesday, February 12, 2020 12:00 – 1:00 p.m. Ward 5-230, PHYSIOLOGY CONFERENCE ROOM 303 E. Chicago St Chicago, Illinois     Coffee and cookies served promptly at 12:00pm Abstract I will describe work from my lab that seeks to understand the biological design of two cellular systems: the kinetochore and the mitotic checkpoint. The kinetochore is a complex protein machine that moves chromosomes during cell division, while the mitotic checkpoint uses a kinetochore-based signaling mechanism to delay cell division if one or more kinetochores are not properly attached to the mitotic spindle. Both systems have been studied extensively using the reductionist approach, but this information does not fully reveal the cellular ‘logic’ that dictates specific aspects of their design. I will discuss one study in particular that explains how the mitotic checkpoint maximizes the accuracy of chromosome segregation while also minimizing unnecessary delays in cell division. I will also indicate how this work provides the foundation for our goal of building synthetic chromosome segregation machines. Host: Dr. Dileep Varma Assistant Professor, Department of Cell and Developmental Biology  Northwestern University, Feinberg School of Medicine              For more information please contact Vanessa Gonzalez, vanessa.g@northwestern.edu      

more

Feb

13

BMG Seminar: Gabriel Rocklin, PhD

Chicago - 10:00 AM - 11:00 AM

Gabriel Rocklin, PhD Assistant Professor, Pharmacology Northwestern University, Feinberg School of Medicine

more

Feb

13

Sodium channel dysfunction in neurodevelopmental disorders - Kevin Bender, PhD

Chicago - 1:00 PM - 2:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Kevin Bender, PhD Associate Professor, Department of Neurology University of California, San Francisco (UCSF) Join us remotely via BlueJeans De novo mutations in the gene SCN2A are associated with a range of neurodevelopmental disorders, including epilepsy, autism spectrum disorder (ASD) and intellectual disability. Interestingly, these different disorders are often associated with different effects on SCN2A function, with gain of function variants most commonly associated with epilepsy and loss of function variants most commonly associated with ASD and intellectual disability. Our lab has been interested primarily in understanding how loss of function variation in SCN2A affects the nervous system. SCN2A encodes the protein NaV1.2, a voltage-gated sodium channel that is expressed throughout the brain, including neocortical excitatory neurons. Using a mouse model heterozygous for Scn2a, we have explored how Scn2a haploinsufficiency affects neocortical circuits. We found that NaV1.2 loss resulted in developmentally distinct deficits in neocortical excitatory neurons.Scn2a haploinsufficiency impaired action potential initiation early in development, whereas a deficit in dendritic excitability persists throughout life. These excitability deficits were associated with impaired excitatory synapses, even when Scn2a is disrupted late in development. These findings suggest that NaV1.2 function is critical throughout life, raising the possibility that restoring normal NaV1.2 function, even later in development, may result in a therapeutic benefit for individuals with ASD-associated SCN2A mutations. Work ongoing in the lab is exploring if and when rescue of Scn2a must occur to achieve therapeutic benefits. Kevin Bender, PhD is an Associate Professor in the Department of Neurology at the University of California, San Francisco (UCSF). His lab is interested in understanding how neurons encode information, with a particular focus on cellular mechanisms that mediate and modulate neuronal excitability. The Bender lab employs a variety of electrophysiological, optical, and genetic techniques to probe information processing across neuronal compartments, and test how these processes are altered in neurological disorders, including addition and neurodevelopmental disorders.  

more

Feb

14

CANCELLED - Department of Physiology Seminar - Adam Hantmann, Ph.D.Department of Physiology Seminar - Adam Hantmann, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Adam Hantmann, Ph.D.

more

Feb

18

Basic Research Seminar: What are Your Cancer Risks from Low Dose Radiation Exposure?

Chicago - 11:30 AM - 12:30 PM

The Basic Research Seminar Series of the Robert H. Lurie Comprehensive Cancer of Northwestern University presents: What are Your Cancer Risks from Low Dose Radiation Exposure?   Gayle Woloschak, PhD Professor Departments of Radiation Oncology, Radiology, and Cell and Molecular Biology Robert H. Lurie Comprehensive Cancer Center Feinberg School of Medicine   Light lunch provided. The Basic Research Seminar series presents prominent basic science speakers weekly to inspire and promote ongoing cancer research at Northwestern University.

more

Feb

18

Department of Microbiology-Immunology: Martin Sapp, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Immediate Early Events of the HPV Life Cycle: Playing Hide and Seek with Host Defenses Speaker: Martin Sapp, PhD / LSU Health Host: Laimoinis Laimins, PhD Topic: Infection with high-risk HPV types is the cause for up to 5% of all human cancers, especially of the cervix, the oropharynx and the anogenital tract. I will be presenting our latest findings regarding the infectious entry and intracellular trafficking of HPV virions to establish infection using relevant cell culture models. Our findings suggest that HPV has evolved unique mechanisms to achieve infection without being sensed by host cell innate immune sensors.

more

Feb

20

BMG Seminar

Chicago - 10:00 AM - 11:00 AM

Speaker TBD

more

Feb

21

"Neuromodulation and the Balance between Goal-directed and Reactive Behavior"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Melissa Warden, Ph.D. Abstract Striking an adaptive balance between persistently working toward goals and quickly responding to important events is essential for survival.  Here, we will discuss our recent research on the role of neuromodulation in regulating the balance between goal-directed and reactive behaviors using optical methods in mice. We will present evidence that phasic activity in serotonin neurons promotes fast, context-dependent behavioral reactions to important environmental/internal events, and will discuss new findings showing that ramping activity in dopamine neurons requires attending to goal proximity.

more

Feb

24

Pharmacology Research Works-in-Progress: Nisha Shrestha, PhD and Andrew Hoffman, PhD

Chicago - 4:00 PM - 5:00 PM

Please join the Department of Pharmacology for a Works-in-Progress presentations Nisha Shrestha, PhD Postdoctoral Fellow in the Laboratory of Murali Prakriya, PhD Andrew Hoffman, PhD Postdoctoral Fellow in the Laboratory of Huiping Liu, MD, PhD            

more

Feb

25

Translational Research in Solid Tumors (TRIST) Seminar

Chicago - 11:30 AM - 12:30 PM

The Translational Research in Solid Tumors (TRIST) Program presents as part of the Basic Research Seminar Series: RNA Methylation in Ovarian Cancer Stem Cells Daniela E Matei, MD Professor Hematology/Oncology and Gynecologic Oncology Northwestern University Feinberg School of Medicine The Death Receptor Fas/CD95 Drives Cancer Stemness and Tumor Growth in Breast Cancer Marcus E Peter, PhD Professor Hematology/Oncology Northwestern University Feinberg School of Medicine Light lunch provided. The Basic Research Seminar series presents prominent basic science speakers weekly to inspire and promote ongoing cancer research at Northwestern University.

more

Feb

25

Department of Microbiology-Immunology: Alexander Mankin, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Stopping the Ribosome at the Finish Line by an Antibacterial Peptide Speaker: Alexander Mankin, PhD / University of Illinois, Chicago Host: M.-N. Frances Yap, PhD Topic: Apidaecin, an antibacterial peptide produced by honeybees is the first known specific inhibitor of translation termination. Biochemical, genetic and genome-wide approaches illuminate the unexpected modes of apidaecin action.   

more

Feb

26

CDB Trainee Seminars Presents: Roslyn Taylor and Amit Rahi

Chicago - 12:00 PM - 1:00 PM

CDB Trainee Seminars Presents: Roslyn Taylor 12:00-12:30 PM Amit Rahi 12:30-1:00 PM Ward 5-230 - Large Physiology Conference Room

more

Feb

27

BMG Seminar: Mikko Taipale, PhD

Chicago - 10:00 AM - 11:00 AM

Mikko Taipale, PhD Research Chair in Functional Proteomics and Proteostasis; CIFAR Azrieli Global Scholar Assistant Professor, Cellular and Biomolecular Research University of Toronto   

more

Feb

27

Department of Microbiology-Immunology: Sarah Stanley, PhD

Chicago - 10:00 AM - 11:00 AM

Title: Metabolic Regulation of M. tuberculosis Infection Speaker: Sarah Stanley, PhD / University of California, Berkeley Host: Hank Seifert, PhD Topic: Macrophages serve the dual role as both the host cell for Mycobacterium tuberculosis (Mtb) infection, and the cell that is primarily responsible for controlling infection by activating microbicidal mechanisms that effectively kill bacteria. We found that metabolic shifts in the host cell are required for effective macrophage-based control of Mtb infection. Host cell metabolites regulate both the transcriptional response to infection and the range of nutrients available to Mtb. I will describe these mechanisms, and will also discuss new work on mechanisms used by Mtb to evade host cell responses.

more

Feb

28

Department of Physiology Seminar - Andrew Singleton, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Andrew Singleton, Ph.D.

more

Mar

02

Pharmacology Seminar: Richard Miller, PhD

Chicago - 4:00 PM - 5:00 PM

Richard J Miller, PhD Alfred Newton Richards Professor of Pharmacology Professor of Pharmacology and Psychiatry and Behavioral Sciences Northwestern University

more

Mar

03

Department of Microbiology-Immunology: Sabra Klein, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Sex is a Biological Variable that Impacts Influenza Vaccine Efficacy Speaker: Sabra Klein, PhD / Johns Hopkins Host: Virology Graduate Students and Postdocs, Coordinator, Dean Procter, PhD Topic: Influenza is an ongoing threat to human health, despite the recommended annual vaccination. Among adults, females typically develop greater vaccine-induced immunity and protection than males, which is caused by sex differential epigenetic modifications in X-linked genes in B cells as well as sex steroid signaling. Furthermore, inactivated as well as universal influenza vaccine-induced immunity declines with age, but to a greater degree in females than males, which is associated with hormonal changes occurring during reproductive senescence. Taken together, both sex steroids and X-linked genes affect antibody production and results in sex-specific differences in the efficacy of vaccination against influenza. This work was supported by the NIH/NIAID Center of Excellence in Influenza Research and Surveillance contract HHS N272201400007C and the NIH/ORWH/NIA Specialized Center of Research Excellence in Sex Differences U54AG062333.

more

Mar

04

CDB Seminar Series: Mechanisms of Blood-Brain Barrier Development, Breakdown and Repair in the CNS

Chicago - 12:00 PM - 1:00 PM

  CDB SEMINAR PRESENTATION: Mechanisms of Blood-Brain Barrier Development, Breakdown and Repair in the CNS   Dritan Agalliu, Ph.D. Assistant Professor Departments of Neurology, Pathology and Cell Biology,  Columbia University Irving Medical Center     Wednesday, March 4, 2020 12:00 – 1:00 p.m. Ward 5-230, PHYSIOLOGY CONFERENCE ROOM 303 E. Chicago St Chicago, Illinois     Coffee and cookies served promptly at 12:00pm   Abstract and References:   Brain endothelial cells form a paracellular and transcellular barrier to blood-borne solutes via tight junctions and scarce endocytotic vesicles. The blood-brain barrier (BBB) plays a pivotal role in the healthy and diseased central nervous system (CNS). BBB damage contributes to increased CNS influx of serum proteins and immune cells, leading to severe pathological and neurological deficits in both ischemic stroke and multiple sclerosis; yet the cell biological mechanisms of how the paracellular BBB dysfunction occurs in these neurological disorders are not very well understood. Dr. Agalliu will present the latest research studies from his laboratory that address the cell biological mechanisms of blood-brain barrier dysfunction in neurological diseases associated with neurovascular dysfunction such as ischemic stroke and multiple sclerosis.  In addition, he will discuss the mechanisms by which Wnt/beta-catenin signaling regulates BBB formation during CNS development and its potential role in BBB repair in neurological diseases.    Knowland, D., Arac, A., Sekiguchi, K., Hsu, M., Lutz, S.E., Perrino, J., Steinberg, G.K., Barres, B.A., Nimmerjahn, A. & Agalliu, D. (2014). Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron, 82, 603-617. PMCID: PMC4016169. Lengfeld, J., Lutz, S.E., Smith, J.R., Diaconu, C.D., Cameron, S., Koffman S., Agalliu, I, Walsh, C. and Agalliu, D. (2017). Endothelial Wnt/beta-catenin signaling reduces immune cell infiltration in multiple sclerosis. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1609905114. PMCID: PMC5320985. Lutz, S.E., Smith, J.R., Kim, D.H., Ellefsen, K., Smith, I.F., Gandhi, S.P. and Agalliu, D. (2017). Caveolin-1 is required for Th1 cell infiltration but not tight junction remodeling at the blood-brain barrier in autoimmune neuroinflammation. Cell Reports 21(8):2104-2117. PMCID: PMC5728697. Mazzoni, J., Smith, J.R., Shahriar, S., Cutforth, T., Ceja, B., and Agalliu, D. (2017). The Wnt inhibitor Apcdd1 coordinates vascular pruning and barrier maturation in retinal blood vessels. Neuron 96(5):1055-1069. PMCID: PMC5728434.      For more information please contact Vanessa Gonzalez, vanessa.g@northwestern.edu

more

Mar

05

Department of Microbiology-Immunology:Marco Jost, PhD

Chicago - 10:00 AM - 11:00 AM

Title: Harnessing CRISPR to Dissect the Molecular Logic of Host-Microbiota Communication Speaker: Marco Jost, PhD / University of California, Berkeley Host: Hank Seifert Topic: Sweeping efforts to map the human microbiome have revealed a staggering complexity of species and molecules, raising a basic question: how do our bodies sense and respond to this diversity in a nuanced manner? I will describe a potentially general solution to this question using the recognition of bacterial cell surface glycolipids by human immune cells as an example. By combining CRISPR screens in primary human dendritic cells and bacterial genetics, I determined that dendritic cells recognize lipopolysaccharide from the gut microbe Bacteroides thetaiotaomicron through combinatorial engagement of multiple receptors whose signaling is integrated to produce a tailored response. This combinatorial sensing mechanism could enable immune cells to parse complex chemical landscapes with a limited repertoire of receptors and could constitute a prominent theme in host-microbiota communication.

more

Mar

05

Translational Research in Solid Tumors (TRIST) Symposium: Intrapatient and Intratumor Heterogeneity

Chicago - 2:00 PM - 6:15 PM

On Thursday, March 5, 2020, the Translational Research in Solid Tumors (TRIST) Program of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University will host the TRIST Symposium on the Chicago campus of Northwestern University. The focus of the program is "Intrapatient and Intratumor Heterogeneity."

more

Mar

06

Department of Physiology Seminar - Alexandra Nelson, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Alexandra Nelson, Ph.D.

more

Mar

10

Department of Microbiology-Immunology: John Leong, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Microbial Tools to Characterize Age-Associated Innate Immune Dysfunction Speaker: John Leong, PhD / Tufts University Host: Alan Hauser, MD, PhD Topic: Aging is associated with increased susceptibility to infection, and comparison of immune effectors of young and aged individuals has identified many functions that become compromised in the elderly. Less understood are which immune functions, when altered with aging, specifically contribute to an inability to resist disease. We have utilized Streptococcus pneumoniae, a pathogen that differentially causes serious illness in the elderly, to probe age-associated innate immune dysfunction that leads to the susceptibility of the aged individual to invasive disease by S. pneumoniae.

more

Mar

12

CDB Seminar Series - Jason Stumpff, PhD

Chicago - 12:00 PM - 1:00 PM

Cell and Developmental Biology Seminar Series Presents: Jason Stumpff, PhD Associate Professor, Department of Molecular Physiology & Biophysics, University of Vermont

more

Mar

12

Autism: A Perspective on the Role of Science to Help Address this Challenge - Louis F. Reichardt, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Louis F. Reichardt, PhD Director, Simons Foundation Autism Research Initiative Dr. Reichardt will describe his personal perspectives as a basic scientist on the barriers to improving our scientific understanding and treatment of autism and the priorities of SFARI, the largest American philanthropic funder of autism-relevant scientific investigation. Louis Reichardt, PhD, joined the Simons Foundation to lead SFARI in 2013. Prior to assuming this post, he was the Jack D. and DeLoris Lange endowed chair in cell physiology at the University of California, San Francisco, where he had directed its renowned neuroscience graduate program since 1988. A Fulbright scholar with an undergraduate degree from Harvard University and a Ph.D. from Stanford University, Reichardt was a research fellow at Harvard Medical School and a Howard Hughes investigator for more than 20 years. The recipient of a Guggenheim fellowship in 1985, he is a fellow of both the American Association for the Advancement of Science and the American Academy of Arts and Sciences. He was one of three founding editors of the journal Neuron and is a senior editor of the Journal of Cell Biology. He serves on the editorial boards of several other journals as well as the scientific advisory boards of the Christopher and Dana Reeve Spinal Cord Injury and Paralysis Foundation and the Myelin Repair Foundation. Reichardt’s research has focused on neurotrophins, a family of proteins that play a key role in neuron functioning, and on another family of proteins that promote the adhesion of nerve cells to each other. He has made major contributions to the study of intracellular signaling pathways that mediate the effects of these proteins — including the Wnt pathway, which may play a role in autism spectrum disorders. Reichardt is also a noted mountaineer who climbed both Mount Everest and K2 by new routes 30 years ago.

more

Mar

12

SQE Distinguished Lecturer: Jin Zhang, PhD

Chicago - 4:30 PM - 5:30 PM

The Simpson Querrey Center for Epigenetics presents: Jin Zhang, PhDDepartment of PharmacologyUniversity of California, San Diego

more

Mar

13

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

more

Mar

17

Department of Microbiology-Immunology: JJ Miranda, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Genomic Approaches to Identifying Interventions for Virus-Associated Malignancies Speaker: JJ Miranda, PhD / Barnard College Host: Eva Gottweni, PhD Topic: Our laboratory studies transcriptional regulation that governs the switch between the quiescent latent form and active replicating state of herpesviruses. In doing so, we can identify protein regulators of genome organization and chromatin essential for the viral life cycle. This basic science forms the foundation for our translational approaches using small molecule inhibitors as potential interventions against virus-associated cancer.

more

Mar

19

Department of Microbiology-Immunology: Lauren Palmer, PhD

Chicago - 10:00 AM - 11:00 AM

Title: Dietary Zinc Deficiency Compromises Immunity to Acinetobacter baumannii Pneumonia Speaker: Lauren Palmer, PhD Host: Hank Seifert, PhD Topic: TBA

more

Mar

23

SQE Distinguished Lecturer: Asifa Akhtar, PhD

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Center for Epigenetics presents: Asifa Akhtar, PhDDirector, Department of Chromatin RegulationMax Planck Institute of Immunobiology and EpigeneticsFreiburg, Germany

more

Mar

23

Annual Julius B. Kahn Lectureship: Michael Snyder, MD, FACS

Chicago - 4:00 PM - 5:00 PM

The Department of Pharmacology is pleased to present a special seminar by the nominated 2020 Julius B. Kahn Visiting Professor. Michael Snyder, MD, FACS Stanford W. Ascherman Professor and Chair of Genetics Director, Center for Genomics and Personalized Medicine Stanford University School of Medicine

more

Mar

24

Department of Microbiology-Immunology: Peter Christie, PhD

Chicago - 12:00 PM - 1:00 PM

Title: The Biological and Structurual Diversity of Bacterial Type IV Secretion Systems Speaker: Peter Christie, PhD / University of Texas, Houston Host: Nicholas Cianciotto, PhD Topic: The bacterial type IV secretion systems (T4SSs) are a diverse superfamily of translocation machines capable of delivering DNA and protein substrates to bacterial and eukaryotic target cells.  We have used in situ cryoelectron tomography to solve the structures of three T4SSs - Legionella pneumophila Dot/Icm, Helicobacter pylori Cag, and E. coli F plasmid Tra - in the native context of the bacterial cell envelope.  Comparisons of these nanomachines offer new structural insights into how substrates engage with and are translocated across the donor envelope to target cells.  I will also summarize our recent mechanistic studies showing that the F plasmid-encoded T4SS translocates several F-encoded proteins to suppress mating-induced mutagenesis (MIM) in bacterial target cells.

more

Mar

25

CDB Faculty Seminars Presents: Drs. Steve Adams and Danijela Maric

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents: Dr. Steve Adams 12:00-12:30pm Dr. Danijela Maric 12:30-1:00pm Ward 5-230, FSM Physiology Large Conference Room

more

Mar

27

CDB Seminar Series - Mohan Balasubramanian, PhD

Chicago - 12:00 PM - 1:00 PM

Cell and Developmental Biology Seminar Series Presents:  Mohan Balasubramanian, PhD Professor, Biomedical Cell Biology, Warwick Medical School, University of Warwick

more

Mar

27

Department of Physiology Seminar - Megan Carey, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Megan Carey, Ph.D.

more

Mar

27

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

more

Mar

31

Basic Research Seminar: The Aging Epigenome: Clues to the Pathogenesis of MDS and AML

Chicago - 11:30 AM - 12:30 PM

The Basic Research Seminar Series of the Robert H. Lurie Comprehensive Cancer of Northwestern University presents: The Aging Epigenome: Clues to the Pathogenesis of MDS and AML   Maria Figueroa, MD Associate Professor University of Miami Miller School of Medicine   Light lunch provided. The Basic Research Seminar series presents prominent basic science speakers weekly to inspire and promote ongoing cancer research at Northwestern University.

more

Mar

31

Department of Microbiology-Immunology: Joseph Dillard, PhD

Chicago - 12:00 PM - 1:00 PM

Title: Peptidoglycan Fragment Production by the Pathogenic Neisseria  Speaker: Joseph Dillard, PhD / University of Wisconsin-Madison Host: Hank Seifert, PhD Topic: The pathogenic Neisseria produce and release small fragments of the cell wall as the bacteria grow. These peptidoglycan fragments include molecules that are agonists for the pattern-recognition receptors NOD1 and NOD2. Human Fallopian tube tissue produces an inflammatory response to the peptidoglycan fragments that results in death and sloughing of ciliated epithelial cells, damage that is partly responsible for the sequlae of pelvic inflammatory disease. We work to understand the mechanisms involved in production of the peptidoglycan fragments, the consequences of mutating genes for peptidoglycan breakdown, and the host responses to Neisseria in human organ culture models of infection.   

more

Apr

03

Center for Translational Pain Research Seminar - Theodore Price, PhD

Chicago - 12:00 PM - 1:00 PM

Theodore Price, PhDEugene McDermott Professor of NeuroscienceProgram Head, Bachelor of Science in NeuroscienceSchool of Behavioral and Brain SciencesUniversity of Texas at Dallas

more

Apr

06

Pharmacology Seminar: Rachel Miller, PhD

Chicago - 4:00 PM - 5:00 PM

Rachel Miller, PhD Assistant Professor Department of Internal Medicine, Division of Rheumatology Rush Medical College

more

Apr

08

CDB Seminar Series - Steven Cappell, PhD

Chicago - 12:00 PM - 1:00 PM

Cell and Developmental Biology Seminar Series Presents:  Steven Cappell, PhD Investigator, Laboratory of Cancer Biology and Genetics, NIH NCI

more

Apr

17

Department of Physiology Seminar - Jill Letugeb, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Jill Letugeb, Ph.D.

more

Apr

20

BMG Guest Seminar Speaker: Michelle Longworth, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics presents: Michelle Longworth, PhDAssociate StaffDepartment of Inflammation and ImmunityLerner Research InstituteCleveland Clinic Lerner College of Medicine  

more

Apr

20

Pharmacology Seminar: Olimpia Meucci, M.D., Ph.D

Chicago - 4:00 PM - 5:00 PM

Olimpia Meucci, M.D., Ph.D.Professor and ChairDepartment of Pharmacology and Physiology Drexel University College of Medicine

more

Apr

22

CDB Seminar Series - Ken Cadwell, PhD

Chicago - 12:00 PM - 1:00 PM

Cell and Developmental Biology Seminar Series Presents:  Ken Cadwell, PhD Associate Professor, Department of Microbiology and Department of Medicine, Skirball Institute, NYU Grossman School of Medicine

more

Apr

23

Center for Autism and Neurodevelopment seminar: Evan Eichler, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Evan Eichler, PhD Professor, Department of Genome Sciences University of Washington Investigator, Howard Hughes Medical Institute    

more

Apr

24

Department of Physiology Seminar - Peter Rapp, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Peter Rapp, Ph.D.

more

Apr

24

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

more

Apr

27

Pharmacology Seminar: Kirill Martemyanov, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Kirill Martemyanov, Ph.D.Co-Chair, Department of NeuroscienceAssociate Professor, Department of Metabolism & AgingFaculty, Graduate ProgramThe Scripps Research Institute, Florida Campus

more

Apr

29

CDB Seminar Series - Khuloud Jaqaman, PhD

Chicago - 12:00 PM - 1:00 PM

Cell and Developmental Biology Seminar Series Presents:  Khuloud Jaqaman, PhD Assistant Proessor, Department of Biophysics, Department of Bioinformatics, UT Southwestern Medical Center

more

Back to top