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Events

Jan

29

Microbiology-Immunology Department: Joseph C. Sun, PhD

Chicago - 12:00 PM - 1:00 PM

"Epigenetic Control of Innate and Adaptive Lymphocyte Responses" Speaker: Joseph C. Sun, PhD -Memorial Sloan Kettering Center, Weill Cornel Medical College Host: Chyung-Ru Wang, PhD TOPIC   Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrated that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and ‘memory’ NK cells possess distinct chromatin accessibility states, and that their epigenetic profiles reveal a ‘poised’ regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.    

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Jan

31

CANCELLED - CANCELLED - BMG Seminar: Transcriptional addiction in diverse tumor lineages- Christopher Vakoc, MD, PhDCANCELLED - BMG Seminar: Transcriptional addiction in diverse tumor lineages- Christopher Vakoc, MD, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Christopher Vakoc, MD, PhDProfessorCold Spring Harbor Laboratory Our laboratory studies how transcription factors, chromatin proteins, and signaling molecules cooperate to maintain the cancer cell state. We make extensive use of CRISPR-Cas9 genetic screens, epigenomics, and biochemistry to study gene regulatory mechanisms. Our goal is to develop a new generation of therapies that reprogram transcription to eliminate cancer cells. The primary focus of our research for several years has been the subset of leukemias caused by rearrangements of the MLL gene. In this disease, we have use RNAi and CRISPR screening to reveal several transcriptional dependencies, including the BET bromodomain protein BRD4. More recently, we have begun exploring epigenetic mechanisms in solid tumors. In my talk, I will discuss how transcription factor master regulators establish inter-tumoral heterogeneity of cell fates in lung and pancreas cancers. 

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Jan

31

CANCELLED - CANCELLED - Autism: A perspective on the role of science to help address this challenge - Louis F. Reichardt, PhDCANCELLED - Autism: A perspective on the role of science to help address this challenge - Louis F. Reichardt, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Louis F. Reichardt, PhDDirector, Simons Foundation Autism Research InitiativeProfessor Emeritus of Physiology and Biochemistry & BiophysicsUniversity of California, San Francisco Dr. Reichardt will describe his personal perspectives as a basic scientist on the barriers to improving our scientific understanding and treatment of autism and the priorities of SFARI, the largest American philanthropic funder of autism-relevant scientific investigation. Louis Reichardt, PhD, joined the Simons Foundation to lead SFARI in 2013. Prior to assuming this post, he was the Jack D. and DeLoris Lange endowed chair in cell physiology at the University of California, San Francisco, where he had directed its renowned neuroscience graduate program since 1988. A Fulbright scholar with an undergraduate degree from Harvard University and a Ph.D. from Stanford University, Reichardt was a research fellow at Harvard Medical School and a Howard Hughes investigator for more than 20 years. The recipient of a Guggenheim fellowship in 1985, he is a fellow of both the American Association for the Advancement of Science and the American Academy of Arts and Sciences. He was one of three founding editors of the journal Neuron and is a senior editor of the Journal of Cell Biology. He serves on the editorial boards of several other journals as well as the scientific advisory boards of the Christopher and Dana Reeve Spinal Cord Injury and Paralysis Foundation and the Myelin Repair Foundation. Reichardt’s research has focused on neurotrophins, a family of proteins that play a key role in neuron functioning, and on another family of proteins that promote the adhesion of nerve cells to each other. He has made major contributions to the study of intracellular signaling pathways that mediate the effects of these proteins — including the Wnt pathway, which may play a role in autism spectrum disorders. Reichardt is also a noted mountaineer who climbed both Mount Everest and K2 by new routes 30 years ago.

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Feb

01

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Feb

04

Pharmacology Research Works-in-Progress: Eugene Wyatt, Ph.D. and Tanima De, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Eugene Wyatt, Ph.D.Research Assistant Professor of Pharmacology"Generating Mouse Models Through the Northwestern TTML" Genetically modified mice are essential research tools used to understand gene function and model disease. The advent of CRISPR gene editing technology has revolutionized the process of generating mouse models, reducing costs and improving efficiency. The Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) has extensive experience using the most cutting-edge CRISPR gene editing techniques to generate genetically modified mice. This includes knock-outs, point mutations, insertion of epitope tags, and conditional alleles. The TTML offers project design consultation, and can target mutations in embryos and embryonic stem cells. In addition, the TTML offers a comprehensive range of services for the Northwestern community. Tanima De, Ph.D.Postdoctoral Fellow, Dr. Minoli Perera Laboratory "Genetic Basis of Pharmacokinetic Variability in African Americans" Genetic variation contributes substantially to the differences in drug response observed within and across populations. African Americans suffer disproportionately from many chronic diseases and adverse drug reactions. Exploring the unique genomic architecture of African Americans can reveal population-specific risk factors that may explain health disparity in drug response. Hepatic cytochrome P450 enzymes account for more than 95% of the phase 1 metabolism of all drugs. We used primary hepatocyte suspension cultures derived from 60 African American non-diseased livers to study genetic basis of pharmacokinetic variability of cytochrome P450 enzymes specific probe drugs. We identified common and population-specific genetic variants that were significantly associated with pharmacokinetic variability. Functional mapping revealed their potentially regulated genes that may play an important role in the regulation of cytochrome P450 enzyme expression. The identified genetic variants therefore may represent causative variants that predispose individuals to adverse events related to several different medications. Our findings may help towards predicting adverse drug events and improving dosage therapy and treatment outcomes in African Americans.

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Feb

05

Microbiology-Immunology Department: Denise Tarnowski

Chicago - 12:00 PM - 1:00 PM

Title TBA Speaker: Denise Tarnowski, Driskill Graduate Program, Lab of Mark Mandel, PhD TOPIC TBA

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Feb

05

Genomic Landscape of Breast Cancer in Diverse Populations - Olufunmilayo I. Olopade, MD, FACP, OON

Chicago - 3:30 PM - 4:30 PM

The Center for Genetic Medicine of Northwestern University welcomes you to attend the Richard A. Scott, MD Lecture on Tuesday, February 5, featuring Olufunmilayo (Funmi) I. Olopade, MD, FACP, OON, Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics; Associate Dean for Global Health; and Director, Center for Clinical Cancer Genetics, University of Chicago. Just us remotely via Blue Jeans (Meeting ID: 333 884 696) OverviewScientific advances have enhanced our understanding of cancer pathogenesis and therapeutic interventions. While these efforts have led to overall improvements in cancer-related health outcomes, disparities across racial/ethnic populations continue to widen. Underrepresented groups frequently demonstrate the highest mortality rates and the shortest windows of survival. Analysis of cancer genomes has provided fundamental insights into the process of malignant transformation, and analyzing cancer genomes have rapidly become an integral part of the practice of clinical oncology, with implications for diagnosis, prognosis, treatment and prevention. Inherited and sporadic cancers often share common mutational events, and when inherited mutations are identified, genetic counseling is an essential component of care. Pathogenic BRCA1 and BRCA2 mutations are the strongest predictors of breast and ovarian cancer risk in women, and may soon be categorized as the strongest predictors of aggressive prostate cancer risk in men. Waiting to treat advanced cancer with targeted therapies is a failure of primary prevention, and population based strategies for risk assessment and management of healthy high-risk individuals will be needed. Dr. Olopade will discuss ongoing research in our group to gain a better understanding of the biological basis of cancer’s heterogeneity across genetic and geographic contexts. Dissolving knowledge gaps that contribute to health care disparities will require adequate inclusions of diverse populations in genomic studies. Biography Olufunmilayo (Funmi) I. Olopade, MD, FACP, OON, a board certified internist and medical oncologist, is the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics, Associate Dean of Global Health and Director, Center for Clinical Cancer Genetics at The University of Chicago. A global leader in cancer genetics, Dr. Olopade seeks to identify those at risk for hereditary breast and ovarian cancer earlier in life, intervene aggressively to reduce risk and preempt disease development, and thereby more effectively control cancer. She studies familial forms of cancers, molecular mechanisms of tumor progression in high-risk individuals as well as genetic and non-genetic factors contributing to tumor progression in diverse populations. Her current laboratory research is focused on using whole genome technologies and bioinformatics to develop innovative approaches to accelerate progress in cancer research and reduce disparities in health outcomes. Dr. Olopade is an expert in cancer risk assessment and individualized treatment for the most aggressive forms of breast cancer, having developed novel management strategies based on an understanding of the altered genes in individual patients. She stresses comprehensive risk reducing strategies and prevention in high-risk populations, as well as earlier detection through advanced imaging technologies. Dr. Olopade is an elected member of the American Society for Clinical Investigation, the Association of American Physicians, the Institute of Medicine of the National Academies, the American Academy of Arts and Sciences and the American Philosophical Society. She has received numerous honors and awards, including honorary degrees from North Central, Dominican, Bowdoin, and Princeton Universities; MacArthur Foundation Fellowship; Doris Duke Distinguished Clinical Scientist and Exceptional Mentor Award; American Cancer Society Clinical Research Professorship; Officer of the Order of the Niger Award; Franklin D. Roosevelt Freedom from Want Award; and the Villanova Mendel Metal Award. She is an elected member of the Association of American Physicians, National Academy of Medicine, American Academy of Arts and Sciences, and the American Philosophical Society, and currently serves on the board of directors for Cancer IQ, Lyric Opera of Chicago, and MacArthur Foundation. Dr. Olopade earned her medical degree from the University of Ibadan College of Medicine in Nigeria. She trained in Internal Medicine at Cook County Hospital in Chicago and in Oncology, Hematology and Cancer Genetics at the Joint Section of Hematology and Oncology at the University of Chicago.   Richard A. Scott, MD, Lecture SeriesThe Scott Lecture Series is co-sponsored by Northwestern University's Driskill Graduate Program (DGP) in Life Sciences, part of the Lectures in Life Sciences series. The Scott Lecture Series was created as an educational platform to appeal to the medical community of Northwestern University. It is funded under the generous bequest of alum Richard A. Scott, MD. After Dr. Scott passed away, his wife and family established the lecture series in honor of Dr. Scott’s lifelong interest in research and learning.

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Feb

07

BMG Seminar: Entrainability and Temperature Compensation in a Three Protein Circadian Clock - Michael Rust, PhD

Chicago - 9:00 AM - 10:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Michael Rust, PhDAssociate Professor of Molecular Genetics and Cell Biology and PhysicsThe University of Chicago Circadian rhythms are a ubiquitous phenomenon in biology where organisms generate internal, near-24 hour rhythms that anticipate the daily cycling of the environment. Health and fitness defects often occur when this internal rhythm is not synchronized to the external world. To achieve this, circadian clocks are able to maintain a similar oscillator period at different temperatures and growth rates, though the underlying mechanisms are poorly understood. The simplest known circadian clock is found in cyanobacteria where the core ~24 hour oscillator can be reconstituted using purified proteins. I will introduce this system and summarize what is known about the interactions that generate oscillations. I will then argue that the observed behavior of circadian clocks in fluctuating environments can be conceptualized as statements about how phosphorylation trajectories change in this purified system. Using a combination of biochemical measurements and mathematical modeling, I will argue that this system achieves physiological clock behavior through a special architecture where all of the kinetic constants are nearly insensitive to temperature and metabolic changes except for a special control point that allows entrainment while having a minimal effect on timing.

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Feb

08

Department of Physiology Seminar Series - Kathleen Cullen, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Kathleen Cullen, Ph.D.

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Feb

08

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Feb

11

Pharmacology Research Works-in-Progress: Adam Gordon, Ph.D. and Kendall Foote

Chicago - 4:00 PM - 5:00 PM

Adam Gordon, Ph.D.Assistant Professor, Department of Pharmacology and Center for Genetic Medicine "Incidental and Pharmacogenetic Findings in Personal Genome Sequencing" Rapidly increasing availability and interest in personal genomics is radically shifting the genetic testing landscape away from traditional, indication-based single-variant or gene tests towards broader panel/exome/genome testing, often in individuals without an indication for testing. Though this shift is accelerating, driven partly through broad-scale sequencing efforts like All of Us, we are only now beginning to understand the rates and types of actionable, pathogenic, and uncertain variation that will be newly uncovered. This talk will explore these issues through my current research in the eMERGE network, and propose new high-throughput approaches to tackle challenges in variant interpretation. Kendall FootePhD Candidate, Dr. Geoff Swanson Laboratory

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Feb

12

Microbiology-Immunoogy Department: James A. Imlay, PhD

Chicago - 12:00 PM - 1:00 PM

"Molecular Explanations for the Toxicity of Oxygen" Speaker: James A. Imlay, PhD -University of Illinois at Urbana-Champaign Host: Bacteriology Students, Coordinator Linda I-Lin Hu, PhD TOPIC For more than 100 years we have understood that high levels of oxygen are overtly toxic and that lower levels chronically damage organisms of all types. This phenomenon has a large impact upon where microbes live, their vulnerability to immune responses, and even their pace of evolution. We have worked to tease apart both the details of damage and the strategies by which cells defend themselves. Recent work has compared how oxygen injures aerotolerant organisms with how it blocks the growth of obligate anaerobes.

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Feb

13

SQE Invited Lecturer: Lucy A. Godley, PhD/MD

Chicago - 2:30 PM - 3:30 PM

The Simpson Querrey Center for Epigenetics presents: Lucy A. Godley, PhD/MDSection of Hematology/Oncology, Departments of Medicine and Human GeneticsThe University of Chicago Title: Regulation of Cell Differentiation by 5-Hydroxymethyleytosine  

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Feb

14

BMG Seminar: Dissecting transcriptional and translational regulatory circuits in human cancers - Zhe Ji, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Zhe Ji, PhDAssistant Professor of PharmacologyNorthwestern University Feinberg School of MedicineAssistant Professor of Biomedical EngineeringNorthwestern University McCormick School of Engineering With the advances of genomics technologies, we now can study the steps of gene expression regulation in a systematic and cost-effective manner. I will present our work developing novel computational tools using machine learning for integrative analyses of multi-omics data, and revealing novel molecular mechanisms controlling gene transcription and RNA translation. And we applied the experimental and computational genomics technologies to decode the key regulatory circuits mediating cancer progression and tumor microenvironment.  

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Feb

15

Department of Physiology Seminar Series - Nicola Grissom, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Nicola Grissom, Ph.D.

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Feb

15

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Feb

18

Pharmacology Research Works-in-Progress: Erika Ramos and Yizhen Zhong

Chicago - 4:00 PM - 5:00 PM

Erika RamosPhD Candidate, Dr. Huiping Liu Laboratory Yizhen ZhongPhD Candidate, Dr. Minoli Perera Laboratory "Discovery of Novel Hepatic eQTLs in African Americans: disparities in Precision Medicine" Abstract: African Americans (AAs) are disproportionately affected by metabolic diseases and drug adverse events, with little genomic and transcriptomic data to advance the knowledge of molecular underpinning of diseases. Here we use primary hepatocytes of AA donors for genome-wide mapping of expression quantitative trait loci (eQTL). We identified 128 eGenes and 9,658 eQTLs not observed in the Genotype-Tissue Expression Project liver cohort. Unique eQTLs contain signatures of positive selection and have larger Fst and LD than overlapping eQTLs. We implicated LY75 as a candidate gene responsible for hemoglobin concentration through a unique eQTL. Our analysis provides comprehensive characterization of potential population specific regulatory variants and their relevance to disease phenotypes.

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Feb

21

BMG Seminar: Harris Wang, PhD

Chicago - 10:30 AM - 11:30 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Harris H. Wang, PhDAssistant Professor of Systems Biology Department of Pathology and Cell BiologyColumbia University  

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Feb

21

SQE Invited Lecturer: Yamini Dalal, PhD

Chicago - 2:00 PM - 3:00 PM

The Simpson Querrey Center for Epigenetics presents: Yamini Dalal, PhDSenior Investigator, Receptor Biology and Gene ExpressionGroup Director, Chromatin Structure and Epigenetic Mechanisms GroupNational Cancer Institute, Bethesda, MD Title: Journey to the Black Hole of the Human Genome Abstract: Unique chromatin structures dictate the functional fate of specific regions of the genome. Centromeres, encoded by the histone variant CENP-A, play an essential role in mitosis. In this lecture, I will discuss the naturally elastic nature of human centromeres, and discuss how such unique biophysical features can hijack non-centromere pathways to drive fragility at subtelomeric breakpoints in the cancer epigenome.  

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Feb

22

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Feb

25

Pharmacology Research Works-in-Progress: Chuyu Chen, Ph.D. and Nicholas Denton, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Chuyu Chen, Ph.D.Postdoctoral Fellow, Dr. Loukia Parisiadou Laboratory Nicholas Denton, Ph.D.Postdoctoral Fellow, Dr. Dai Horiuchi Laboratory

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Feb

26

Microbiology-Immunology Department:Daniel Perez

Chicago - 12:00 PM - 1:00 PM

" Immunoregulatory Targeting of the Type 1 IFN Response Protects Against Mortality in a Murine Model of Neonatal HSV-1 Encephalitis" Speaker: Daniel Perez, Driskill Graduate Program, Lab of Richard Longnecker, PhD TOPIC Newborn infection with herpes simplex virus (HSV) is a serious, life-threatening condition with an incidence of 1 in 3,200 deliveries in the U.S. Unlike adult infections, which are commonly asymptomatic, over 50% of neonatal HSV infections result in disseminated disease or encephalitis. However, the nature of these age-dependent differences to HSV infection remains largely understudied. Here we explore how intrinsic differences in the type I IFN pathway in the central nervous system between the adult and the newborn correlate with increased susceptibility to HSV-1 infection and how this pathway can be modulated to provide protection to the newborn. Our studies will provide important insights into the mechanisms controlling age-dependent differences in the innate immune response to CNS injury throughout development and may lead to novel therapeutic approaches.

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Feb

28

BMG Seminar: Shannon Elf, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Shannon Elf, PhDAssistant Professor The University of Chicago  

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Mar

01

"Mechanism of Rapid Antidepressant Action"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Lisa Monteggia, Ph.D. Clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant responses in patients with major depressive disorder. Data will be presented showing that ketamine mediated blockade of NMDA receptors at rest targets a specific signaling cascade that involves deactivation of eukaryotic elongation factor 2 (eEF2) kinase, resulting in reduced eEF2 phosphorylation and desuppression of rapid dendritic protein translation, including BDNF, which then contributes to synaptic plasticity mechanisms. These findings identify critical determinants of how blocking spontaneous neurotransmission impacts synaptic plasticity with implications for ketamine mediated antidepressant responses.

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Mar

01

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Mar

05

Microbiology-Immunology Department: Katherine A. Radek, PhD

Chicago - 12:00 PM - 1:00 PM

"Cholinergic Regulation of Skin Antimicrobial Responses in Models of Injury and Infection" Speaker: Katherine A. Radek, PhD - Loyola University Chicago Host: Melissa Brown, PhD TOPIC The Radek laboratory focuses on how epidermal cholinergic signaling controls antimicrobial responses in the skin. The pathways by which skin antimicrobial responses are induced have been more thoroughly investigated, while those mechanisms which suppress them have not been fully elucidated. We established that activation of keratinocyte nicotinic acetylcholine receptors (nAChRs), specifically CHRNA7, dampens antimicrobial responses in several models of skin bacterial infection and wound healing. This suggests that CHRNA7 could be a novel target to boost skin antimicrobial responses as a means to improve infection and wound healing outcomes.

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Mar

07

Center for Autism and Neurodevelopment seminar - Akira Sawa, MD, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Akira Sawa, MD, PhDDirector, Johns Hopkins Schizophrenia CenterProfessor of Psychiatry and Behavioral SciencesJohns Hopkins University School of Medicine

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Mar

08

Department of Physiology Seminar Series - Amanda Law, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Amanda Law, Ph.D.

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Mar

08

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Mar

11

Pharmacology Seminar: Francisco Bezanilla, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Francisco Bezanilla, Ph.D.Lillian Eichelberger Cannon ProfessorDepartment of Biochemistry and Molecular BiologyThe University of Chicago

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Mar

12

Microbiology-Immunology Department: Thomas M. Krisite, PhD

Chicago - 12:00 PM - 1:00 PM

"Transitions in Chromatin States Modulates Herpes Simplex Virus Infection, Latency, & Reactivation" Speaker: Thomas M. Kristin, PhD - National Institute of Allergy & Infectious Diseases, NIH Host: Laimonis Laimins, PhD TOPIC Despite the availability of antivirals, herpes simplex virus remains a widely prevalent pathogen responsible for recurrent oral and genital lesions, developmental and neurological issues in infected newborns, and viral-mediated blindness. Modulation of the epigenetic state of the HSV genome plays a critical role in determining the course of viral lytic infection, latency, and signal-mediated reactivation. The laboratory focuses on the mechanisms by which an essential cellular transcriptional coactivator and its associated complexes mediate dynamic transitions in herpes simplex virus-associated chromatin to promote initiation of lytic infection and reactivation from latency. We are also exploring the use of inhibitors that target specific epigenetic factors regulating HSV gene expression in order to modulate the state of the viral chromatin and thereby suppress infection, shedding, and reactivation from latency in vivo.

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Mar

15

Department of Physiology Seminar Series - Jeanne Paz, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Jeanne Paz, Ph.D.

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Mar

15

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Mar

18

"An RNA-Centric View of Neurodevelopment: From Single Nucleotide Resolution Maps to Functions" - Chaolin Zhang, Ph.D.

Chicago - 4:00 PM - 5:00 PM

The Department of Pharmacology Seminar Series is pleased to welcome Dr. Chaolin Zhang. Chaolin Zhang, Ph.D.Assistant ProfessorDepartments of Systems Biology and Biochemistry & Molecular BiologyColumbia University Medical Center Abstract:Dr. Chaolin Zhang is an Assistant Professor in Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, and Motor Neuron Center at Columbia University since 2012. His lab uses an integrative approach to study neuronal RNA-binding proteins and how they regulate the transcriptomic diversity in the nervous system through alternative splicing in both normal and disease contexts. A current focus of the lab is to elucidate mechanisms underlying the precise timing of dynamic transcript isoform switches and the functional consequences during neural development. These works are done in model systems including in vitro neural differentiation from embryonic stem cells and mice. Dr. Zhang’s work has contributed to mapping protein-RNA interactions at single nucleotide resolution, to constructing neuronal RNA regulatory networks with high sensitivity and specificity, and to dissecting their function in neurodevelopment.

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Mar

22

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Mar

25

Pharmacology Seminar: Indira M. Raman, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Indira M. Raman, Ph.D.Bill and Gayle Cook ProfessorDepartment of NeurobiologyWeinberg School of Arts & Sciences

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Mar

26

Microbiology-Immunology Department: Lubov Grigoryeva

Chicago - 12:00 PM - 1:00 PM

"Endosomal TLRs are Major Pathways to Recognizing Legionella pneumophila in Human Macrophages" Speaker: Lubov Grigoryeva, Driskill Graduate Program, Lab of Nicholas Cianciotto, PhD TOPIC Legionella pneumophila is a gram-negative bacterium that causes a severe form of pneumonia known as Legionnaire’s disease. Preliminary data from our laboratory revealed that the recognition of wild-type L. pneumophila by human macrophages deviates from previously reported pathways in murine macrophages, calling into question the field’s reliance on murine-based experimentation. My project seeks to understand the mechanisms of innate immune signaling in human macrophages after Lp infection.

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Mar

29

Department of Physiology Seminar Series - Massimo Scanziani, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Massimo Scanziani, Ph.D.

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Mar

29

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

01

Joint Pharmacology & Seizure Focus Seminar: Alex Shcheglovitov, Ph.D.

Chicago - 12:00 PM - 1:00 PM

Joint Department of Pharmacology and Seizure Focus Forum Seminar Alex Shcheglovitov, Ph.D.Assistant Professor of Neurobiology & AnatomyAdjunct Assistant Professor of Psychiatry and BioengineeringUniversity of Utah    

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Apr

05

Department of Physiology Seminar Series - Peter Strickland, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Peter Strickland, Ph.D.

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Apr

05

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Apr

08

Pharmacology Seminar: Michelle Day, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Michelle Day, Ph.D.Research Associate ProfessorDepartment of PhysiologyFeinberg School of Medicine

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Apr

12

Department of Physiology Seminar Series - Denise Cai, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Denise Cai, Ph.D.

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Apr

12

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

15

Pharmacology Seminar: Randy D. Blakely, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Randy D. Blakely, Ph.D.Executive Director of FAU Brain InstituteProfessor of Biomedical ScienceFlorida Atlantic University

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Apr

19

Department of Physiology Seminar Series - Zachary Knight, Ph.D.

No Location - 12:00 PM - 1:00 PM

The department of Physiology welcomes Zachary Knight, Ph.D.

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Apr

19

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Apr

22

Julius B. Kahn Lecture: Mark Von Zastrow, M.D., Ph.D.

Chicago - 4:00 PM - 5:00 PM

The Department of Pharmacology is pleased to present a special seminar by the nominated Julius B. Kahn Visiting Professor. Mark Von Zastrow, M.D., Ph.D.Professor of Psychiatry University of California San Francisco  

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Apr

26

BMG Journal Club

No Location - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

29

Pharmacology Seminar: Jean Ju Chung, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Jean Ju Chung, Ph.D.Assistant Professor of Cellular & Molecular PhysiologyYale School of Medicine

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