High Impact-Factor Research 2015

Advani RH, Hong F, Fisher RI, Bartlett NL, Robinson KS, Gascoyne RD, Wagner H Jr, Stiff PJ, Cheson BD, Stewart DA, Gordon LI, Kahl BS, Friedberg JW, Blum KA, Habermann TM, Tuscano JM, Hoppe RT, Horning SJ. Randomized Phase III Trial Comparing ABVD Plus Radiotherapy With the Stanford V Regimen in Patients With Stages I or II Locally Extensive, Bulky Mediastinal Hodgkin Lymphoma: A Subset Analysis of the North American Intergroup E2496 Trial. Journal of Clinical Oncology. 2015 Jun 10;33(17):1936-42. 

Antic I, Biancucci M, Zhu Y, Gius DR, Satchell KJ. Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain. Nature Communications. 2015 Jun 8;6:7396. 

Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC. Phosphatidylinositol 3-kinase signaling determines kidney size. Journal of Clinical Investigation. 2015 Jun 1;125(6):2429-44. 

Hargrove LJ, Young AJ, Simon AM, Fey NP, Lipschutz RD, Finucane SB, Halsne EG, Ingraham KA, Kuiken TA. Intuitive Control of a Powered Prosthetic Leg During Ambulation A Randomized Clinical Trial. JAMA-Journal of the American Medical Association. 2015 Jun;313(22):2244-2252.

Ichida JK, Kiskinis E. Probing disorders of the nervous system using reprogramming approaches. The EMBO Journal. 2015 Jun 3;34(11):1456-1477.

Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, Farlow MR, Grafman J, Huey ED, Ryung Han M, Beecher S, Geller ET, Kretzschmar HA, Roeber S, Gearing M, Juncos JL, Vonsattel JP, Van Deerlin VM, Grossman M, Hurtig HI, Gross RG, Arnold SE, Trojanowski JQ, Lee VM, Wenning GK, White CL, Höglinger GU, Müller U, Devlin B, Golbe LI, Crook J, Parisi JE, Boeve BF, Josephs KA, Wszolek ZK, Uitti RJ, Graff-Radford NR, Litvan I, Younkin SG, Wang LS, Ertekin-Taner N, Rademakers R, Hakonarsen H, Schellenberg GD, Dickson DW. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 2015 Jun 16;6:7247.

Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, Smith JP, Walker AJ, Kohler ME, Venkateshwara VR, Kaplan RN, Patterson GH, Fry TJ, Orentas RJ, Mackall CL. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nature Medicine. 2015 Jun;21(6):581-90. 

Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, Balling R, Berger AC, Bleyl S, Chakravarti A, Chantratita W, Chisholm RL, W Dissanayake VH, Dunn M, Dzau VJ, Han BG, Hubbard T, Kolbe A, Korf B, Kubo M, Lasko P, Leego E, Mahasirimongkol S, Majumdar PP, Matthijs G, McLeod HL, Metspalu A, Meulien P2, Miyano S, Naparstek Y, O'Rourke PP, Patrinos GP, Rehm HL, Relling MV, Rennert G, Rodriguez LL, Roden DM, Shuldiner AR, Sinha S, Tan P, Ulfendahl M, Ward R, Williams MS, L Wong JE, Green ED, Ginsburg GS. Global implementation of genomic medicine: We are not alone. Science Translational Medicine. 2015 Jun 3;7(290):290ps13.

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015 Jun 11;522(7555):216-20.

Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG. Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nature Communications. 2015 Jun 1;6:7254. 

Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA - Journal of the American Medical Association. 2015 Jun 9;313(22):2263-2273.

Thompson BJ, Bhansali R, Diebold L, Cook DE, Stolzenburg L, Casagrande AS, Besson T, Leblond B, Désiré L, Malinge S, Crispino JD. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. Journal of Experimental Medicine. 2015 Jun 1;212(6):953-70. 

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migrationJournal of Experimental Medicine. 2015 Jun 29;212(7):1021-41. 

Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K. Cell biology: Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60. 

Zimbler DL, Schroeder JA, Eddy JL, Lathem WW. Early emergence of Yersinia pestis as a severe respiratory pathogen. Nature Communications. 2015 Jun 30;6:7487. 

Belknap SM. Review: Statins do not increase adverse cognitive effects in patients with or without initial cognitive impairment. Annals of Internal Medicine. 2015 May 19;162(10):JC6. 

Dorfleutner A, Chu L, Stehlik C. Inhibiting the inflammasome: one domain at a time. Immunological Reviews. 2015 May;265(1):205-16. 

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S. Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation. Proceedings of the National Academy of Sciences U S A. 2015 May 12;112(19):6206-11. 

Pandolfino JE, Gawron AJ. Achalasia: a systematic review. JAMA- Journal of the American Medical Association. 2015 May 12;313(18):1841-52. 

Randeria PS, Seeger MA, Wang XQ, Wilson H, Shipp D, Mirkin CA, Paller AS. siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. Proceedings of the National Academy of Sciences U S A. 2015 May 5;112(18):5573-8. 

Ross MB, Ku JC, Vaccarezza VM, Schatz GC, Mirkin CA. Nanoscale for m dictates mesoscale function in plasmonic DNA-nanoparticle superlattices. Nature Nanotechnology. 2015 May;10(5):453-8. 

Tolia VN, Patrick SW, Bennett MM, Murthy K, Sousa J, Smith PB, Clark RH, Spitzer AR. Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs. New England Journal of Medicine. 2015 May 28;372(22):2118-26. 

Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proceedings of the National Academy of Sciences U S A. 2015 May 12;112(19):6176-81. 

Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, Dada L, Ridge KM, Chandel NS, Liu J. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nature Immunology. 2015 May;16(5):458-66. 

Alayyoubi M, Leser GP, Kors CA, Lamb RA. Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex. Proceedings of the National Academy of Sciences U S A. 2015 Apr 7;112(14):E1792-9.

Bharat A, Cunningham SA, Scott Budinger GR, Kreisel D, DeWet CJ, Gelman AE, Waites K, Crabb D, Xiao L, Bhorade S, Ambalavanan N, Dilling DF, Lowery EM, Astor T, Hachem R, Krupnick AS, DeCamp MM, Ison MG, Patel R. Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans. Science Translational Medicine. 2015 Apr 22;7(284):284re3. 

Brodin JD, Auyeung E, Mirkin CA. DNA-mediated engineering of multicomponent enzyme crystals. Proceedings of the National Academy of Sciences U S A. 2015 Apr 14;112(15):4564-9.

Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, D Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK. Urinary metabolic signatures of human adiposity. Science Translational Medicine. 2015 Apr 29;7(285):285ra62. 

Howard JD, Gottfried JA, Tobler PN, Kahnt T. Identity-specific coding of future rewards in the human orbitofrontal cortex. Proceedings of the National Academy of Sciences U S A. 2015 Apr 21;112(16):5195-200

Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng CY, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, Stegh AH. miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Genes & Development. 2015 Apr 1;29(7):732-45. 

Pei L, Mu Y, Leblanc M, Alaynick W3, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism. Cell Metabolism. 2015 Apr 7;21(4):628-36. 

Scott RP, Quaggin SE. The cell biology of renal filtration. Journal of Cell Biology. 2015 Apr 27;209(2):199-210.

Tayi AS, Kaeser A, Matsumoto M, Aida T, Stupp SI. Supramolecular ferroelectrics. Nature Chemistry. 2015 Apr;7(4):281-94. 

Albrecht LV, Zhang L, Shabanowitz J, Purevjav E, Towbin JA, Hunt DF, Green KJ. GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics. Journal of Cell Biology. 2015 Mar 2;208(5):597-612. 

Diabetic Retinopathy Clinical Research Network, Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, Antoszyk AN, Arnold-Bush B, Baker CW, Bressler NM, Browning DJ, Elman MJ, Ferris FL, Friedman SM, Melia M, Pieramici DJ, Sun JK, Beck RW. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. New England Journal of Medicine. 2015 Mar 26;372(13):1193-203. 

Larsen JB, Jensen MB, Bhatia VK, Pedersen SL, Bjørnholm T, Iversen L, Uline M, Szleifer I, Jensen KJ, Hatzakis NS, Stamou D. Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nature Chemical Biology. 2015 Mar;11(3):192-4. 

Norton JJ, Lee DS, Lee JW, Lee W, Kwon O, Won P, Jung SY, Cheng H, Jeong JW, Akce A, Umunna S, Na I, Kwon YH, Wang XQ, Liu Z, Paik U, Huang Y, Bretl T, Yeo WH, Rogers JA. Soft, curved electrode systems capable of integration on the auricle as a persistent brain-computer interface. Proceedings of the National Academy of Sciences U S A. 2015 Mar 31;112(13):3920-5. 

Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, Gryaznov SM. Immunomodulatory spherical nucleic acids. Proceedings of the National Academy of Sciences U S A. 2015 Mar 31;112(13):3892-7. 

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari NN, Koch M, Saadati M, Benner A, Büchler MW, Jäger D, Halama N, Khazaie K, Weitz J, Beckhove P. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. Journal of Clinical Investigation. 2015 Mar 2;125(3):1364. 

Weinberg SE, Sena LA, Chandel NS. Mitochondria in the Regulation of Innate and Adaptive Immunity. Immunity. 2015 Mar 17;42(3):406-417. 

Harris KD, Shepherd GM. The neocortical circuit: themes and variations. Nature Neuroscience. 2015 Feb;18(2):170-181.

Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C, Anderson EJ, Grijalva CG, Self WH, Zhu Y, Patel A, Hymas W, Chappell JD, Kaufman RA, Kan JH, Dansie D, Lenny N, Hillyard DR, Haynes LM, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, Wunderink RG, Edwards KM, Pavia AT, McCullers JA, Finelli L; CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among U.S. children. New England Journal of Medicine. 2015 Feb 26;372(9):835-45. 

Jones MR, Seeman NC, Mirkin CA. Nanomaterials. Programmable materials and the nature of the DNA bond. Science. 2015 Feb 20;347(6224):1260901. 

Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME,Wustman BA, Gandy S. Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. Molecular Psychiatry. 2015 Feb;20(1):109-17. 

Köster S, Weitz DA, Goldman RD, Aebi U, Herrmann H. Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks. Current Opinion in Cell Biology. 2015 Feb;32C:82-91. 

Luo Z, Gao X, Lin C, Smith ER, Marshall SA, Swanson SK, Florens L, Washburn MP, Shilatifard A. Zic2 is an enhancer-binding factor required for embryonic stem cell specification. Molecular Cell. 2015 Feb 19;57(4):685-94. 

Mehta MM, Chandel NS. Targeting metabolism for lupus therapy. Science Translational Medicine. 2015 Feb 11;7(274):274fs5. 

McNally EM, Barefield DY, Puckelwart MJ. The Genetic Landscape of Cardiomyopathy and Its Role in Heart Failure. Cell Metabolism. 2015 Feb 3;21(2):174-182.

Merkow RP, Ju MH, Chung JW, Hall BL, Cohen ME, Williams MV, Tsai TC, Ko CY, Bilimoria KY. Underlying reasons associated with hospital readmission following surgery in the United States. JAMA- Journal of the American Medical Association. 2015 Feb 3;313(5):483-95. 

Morgan MA, Shilatifard A. Chromatin signatures of cancer. Genes & Development. 2015 Feb 1;29(3):238-249.

Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O'Halloran TV. Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nature Chemistry. 2015 Feb;7(2):130-9. 

Walz AL, Ooms A, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Bowlby R, Brooks D, Ma Y, Mungall A, Moore RA, Schein J, Marra MA, Huff V, Dome JS, Chi YY, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Jafari N, Ross N, Gastier-Foster JM, Perlman EJ. Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors. Cancer Cell. 2015 Feb 9;27(2):286-97. 

Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA- Journal of the American Medical Association. 2015 Feb 10;313(6):584-93.

Arterburn DE, Olsen MK, Smith VA, Livingston EH, Van Scoyoc L, Yancy WS Jr, Eid G, Weidenbacher H, Maciejewski ML. Association between bariatric surgery and long-term survival. JAMA-Journal of the American Medical Association. 2015 Jan 6;313(1):62-70. 

Chen F, Gao X, Shilatifard A. Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide. Genes & Development. 2015 Jan 1;29(1):39-47. 

Chu HY, Atherton JF, Wokosin D, Surmeier DJ, Bevan MD. Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex. Neuron. 2015 Jan 21;85(2):364-76. 

GBD 2013 Mortality and Causes of Death Collaborators (includes Sawoop M). Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Jan 10;385(9963):117-171.

Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O'Connell PJ, Gallon L, Colvin R, Schroppel B, He JC, Murphy B. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. Journal of Clinical Investigation. 2015 Jan;125(1):208-21. 

Park DJ, Zhang C, Ku JC, Zhou Y, Schatz GC, Mirkin CA. Plasmonic photonic crystals realized through DNA-programmable assembly. Proceedings of the National Academy of Sciences U S A. 2015 Jan 27;112(4):977-81.

Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, Velasco PT, MacRenaris K, Waters EA, Lu C, Phan J, Lacor P, Prasad P, Dravid VP, Klein WL. Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nature Nanotechnology. 2015 Jan;10(1):91-8.

Weinberg SE, Chandel NS. Targeting mitochondria metabolism for cancer therapy. Nature Chemistry Biology. 2015 Jan;11(1):9-15.

Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes & Development. 2015 Jan 15;29(2):123-8.