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Funded Research Projects

See below for a list of our research team's ongoing, funded atrial fibrillation (AFib) research projects.

 MRI of diffuse left ventricular fibrosis in AFib

Funding source: NIH 1R01HL116895

PI: Kim

To develop a novel MRI method to quantify diffuse left ventricular fibrosis in patients who are undergoing AFib ablation, for prediction of LV functional improvement after ablation

 MRI of left atrial hemodynamic disorder in AFib

Funding source: NIH 1R21AG055954

PI: Kim/Markl

To develop a new imaging test needed for establishing a risk stratification system based on physiologic factors in thrombus formation

 Left atrial 4D hemodynamics and thromboembolic risk in AFib

Funding source: AHA Grant-in-Aid 12GRNT12080032

Co-PI: Markl/Lee

To assess 4D flow magnetic resonance imaging (MRI) methods as a risk factor for thrombus formation in AFib

 4D magnetic resonance imaging for atrial flow assessment in AFib

Funding source: NIH 1R21HL113895-01A1

PI: Lee/Markl

To quantify blood flow in the right and left atria in AFib

 AFib burden, vascular disease of the brain and cardiac MRI in MESA

Funding source: NIH via Univ of Washington 5R01HL127659-02

PI: Greenland

To assess AFib in relation to cerebral and cardiac structure and function and cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA)

 Midwest Regional Center Women’s Health Initiative Extension 2015-2020

Funding source: NIH via Ohio State HHSN268201100002C

PI: Greenland  

To perform ancillary studies on WHI dataset, engage other investigators, and mentor new scientists on the WHI resource; AFib is one of the outcomes tracked by the study and this resource has led to the WHISH-STAR project

 Multi-Ethnic Study of Atherosclerosis (MESA) Chicago Field Center – Task 1

Funding source: NIH via Univ of Washington  HHSN268201500003I

PI: Greenland       

To examine factors associated with progression of subclinical CVD and identify high-risk asymptomatic persons for preventive measures; MESA has provided a laboratory for population studies of AFib, and more than 50 papers on AFib have been published so far

 Validation of an AFib-sensing smartwatch algorithm

Funding source: AliveCor

PI: Passman

To validate the accuracy of an AFib-sensing smarthwatch for AFib detection

 The impact of race/ethnicity differences on novel oral anticoagulant ultization, stroke outcomes and bleeding risks

Funding source: Bristol-Myers Squibb Company

PI: Passman/Greenland

To evaluate in stroke and bleeding risk in minorities with AFib

 The WHI Strong and Heathy SilenT Atrial Fibrillation Recording Study (WHISH STAR)

Funding source: NIH via Stanford R01HL136390-01

Co-I: Greenland

To measure the effect of physical activity intervention on incident AFib and the effect of AFib screening on rates of anticoagulant use in high-risk women

 The role of Pak1 in the development of AFib

Funding source: NIH R01HL128330

Co-I: Arora 

To understand the role of Pak-1 signaling in the creation of substrate for triggered activity in AFib

 Electrogram morphology recurrence identifies areas of consistent activation directions and rotor activity in a canine model of AFib

Funding source: AHA 12GRNT12070241

PI: Arora

To determine novel measure of electrogram morphology (Electrogram Morphology Recurrence) can help identify sites of driver rotors in AFib

 Oxidative stress contributes to AFib by causing remodeling of the autonomic nervous system

NIH (NHLBI) RO1 R01HL140061

PI: Arora

To determine whether oxidative stress creates substrate for atrial fibrillation by causing structural and functional remodeling of the autonomic nervous system