Northwestern University Feinberg School of Medicine
Faculty Profiles

Focus of Work

Bio

Research in our lab focuses on developing statistical machine learning based algorithms and informatics solutions for knowledge extraction in biology and medicine. Our ongoing research work, funded by National Library of Medicine/NIH R01, focuses on developing novel bioinformatics methods to help in silico discovery and research for accelerating the linkage of phenotypic and genomic information at gene-isoform level. The overarching goal of the lab is to translate data from high dimensional (-om...[Read full text]Research in our lab focuses on developing statistical machine learning based algorithms and informatics solutions for knowledge extraction in biology and medicine. Our ongoing research work, funded by National Library of Medicine/NIH R01, focuses on developing novel bioinformatics methods to help in silico discovery and research for accelerating the linkage of phenotypic and genomic information at gene-isoform level. The overarching goal of the lab is to translate data from high dimensional (-omic) platforms (e.g., NextGen sequencing) to derive experimentally interpretable and testable discovery models for the identification and characterization of transcript-variants/protein isoforms, networks and pathways involved in normal and disease cells. Our data science group collaborates with experimental and clinical researchers towards identification of genetic and epigenetic signatures for identification of subsets of cancer patients who may benefit from therapeutic intervention and guide the understanding of drug activity in patient tumors, towards the goals of precision medicine (for example, JCO Clin Cancer Inform. 2019 Apr;3:1-9. doi: 10.1200/CCI.18.00096.)[Shorten text]

Academic Focus

Data Science; Application of statistical machine learning methods; precision medicine; isoform-level gene regulation

Keywords


Education and Certification

  • PhD: Indian Agricultural Statistics Research Institute, Statistics (1996)

Contact

312-503-2320

Rubloff Building Suite 11-168
750 N Lake Shore
Chicago IL 60611