Provide high quality microsurgical services to support all principal investigators in need of small animal surgical models and to offer consultations on any issues pertaining to microsurgical techniques in small animal models.
Develop novel animal models that may complement ongoing studies or help investigators explore novel ways to test their hypotheses in vivo.
Zheng Jenny Zhang, MD
Staff and Facilities
The microsurgical core facility has two surgical stations for the performance of microscopic animal surgery. It is staffed by four experienced surgeons who have succesfully performed rodent procedures including heart, kidney, liver, intestine, ovary and pancreas transplantation, as well as skin grafting and ileocecal resection.
Research Projects Previously/Currently Utilizing Core
Mouse kidney transplant to study CMV latency and reactivation
Mouse kidney transplantation to study the role of TLR signaling and biomarkers in kidney injury, specifically including ischemia reperfusion injury
Mosue heart and kidney transplant to study the role of Th17 in allograft rejection and transplant nephropathy
Ileocecal reseaction to study PI3K signaling in small bowel regeneration
Ovarian transplant to study biomaterials in follicle growth and oocyte maturation
Small bowel and pancreas transplant to study mechanism of antigen-specific CD8 tolerance in inflammatory bowel disease