Clinical Trials

Clinical and Outcomes Research under the direction of the Department of Dermatology is conducted at the Northwestern University Feinberg School of Medicine,  Ann & Robert H. Lurie Children's Hospital of Chicago, and Northwestern Lake Forest Hospital dermatology clinics.

For more information about the research or participation, please call our office at 312-695-6829.

Trials
DERMATOLOGY TISSUE ACQUISITION AND REPOSITORY
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and ot…
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and other tissue samples for use in a biorepository. By operating this biorepository, the Department of Dermatology hopes to develop a better understanding of skin diseases (meaning the knowledge about how cells in the skin behave and react to medical treatments) among researchers at Northwestern University and other approved researchers. This basic knowledge is expected to help the development of more effective patient care and new treatment methods.
-Having specimens collected as part of a standard of care procedure;
-Have a skin disease which researchers want samples of in order to further understand
it; or
-Qualify as a healthy volunteer whose samples researchers can use as control samples
for research.
West, Dennis PWest, Dennis P
  • Map it 676 North St. Clair
    Chicago, IL
STU00009443
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Sozzer, Fatima 312 695 0287
A Pilot, Split-Face Randomized, Evaluator Blinded Study on the Effectiveness of a Bipolar Fractional Radiofrequency System versus 1550-nm Fractional Photothermolysis for the Treatment of Acne Scars.
The purpose of this study is to compare the effectiveness of the ePrime fractional radiofrequency sys…
The purpose of this study is to compare the effectiveness of the ePrime fractional radiofrequency system to the 1550-nm fractional photothermolysis system (Fraxel) in the ability to improve acne scar appearance. ePrime is a minimally invasive procedure that uses a small needle to deliver radiofrequency (radio waves that are converted to heat) energy into the deep areas of the skin without damaging the surface of the skin. This procedure allows for the creation of new collagen, elastin, and hyaluronic acid (natural substances found in the body). Fraxel is a laser that works below the skin’s surface from the top down, correcting cosmetic problems such as acne scarring.
You have boxcar and/or icepick scars on both sides of your face and are looking for treatment for improving acne scar appearance. Your part in this study will last 4 months and will involve 4 visits.
Alam, MuradAlam, Murad
  • Map it 676 North St. Clair
    Chicago, IL
NCT01976260 STU00084041
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Samuelson, Emily 312 695 4761
A Pilot Study Comparing the Efficacy of Glycolic Acid Peels vs. Salicylic Acid Peels for the Treatment of Melasma: A Split-Faced, Randomized Control Trial
The purpose of this study is to find out the safety and effectiveness of Glycolic Acid Chemical Peels compared to Salicylic Acid Chemical Peels f…
The purpose of this study is to find out the safety and effectiveness of Glycolic Acid Chemical Peels compared to Salicylic Acid Chemical Peels for the treatment of melasma.
You have facial melasma and are in need of treatment. Your part in this study will last approximately 16 weeks and will involve 5 visits to the study site.
Alam, MuradAlam, Murad
  • Map it 676 North St. Clair
    Chicago, IL
NCT01976286 STU00084250
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Samuelson, Emily 312 695 4761
Treatment of Facial Flushing with Botulinum Toxin A Injections: A Split-face, Double-blinded, Randomized Control Trial
The purpose of this study is to find out if botulinum toxin A (botox®) can be used to treat facial flushing.To determine if botox can be used to treat facial flushing, botox will …
The purpose of this study is to find out if botulinum toxin A (botox®) can be used to treat facial flushing.To determine if botox can be used to treat facial flushing, botox will be compared to saline injections, which will have no active drug.
You have facial flushing and have decided you want treatment. Your part in the study will last approximately 2 months (8 weeks).
Alam, MuradAlam, Murad
  • Map it 676 North St. Clair
    Chicago, IL
NCT02216838 STU00097514
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Samuelson, Emily 312 695 4761
Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides)
To evaluate the safety and effectiveness of the topical ointment (cream), SGX301, in combination with light therapy in patients with cutaneous T-cell lymphoma.
Must be 18 years of age or older, with a clinical diagnosis of Cutaneous T- Cell Lymphoma, Myucosis Fungoides, Stage IA. Stage IB, or Stage IIA, and willing to refrain from sunbathing for duration of the study.
Guitart, JoanGuitart, Joan
  • Map it 676 North St. Clair
    Chicago, IL
NCT02448381 STU00200530
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Serrano, Linda 312 695 6786
Observational US Study Assessing Outcomes, Treatment Patterns, AEs, QOL in MF-CTCL Patients and Treated With Valchlor
The purpose of this study is to better understand: the use of Valchlor®; the disease of MF-CTCL; the health outcomes in patients treated with Valchlor® under care by your doctor.
Adult patients currently being treated with Valchlor®, for the treatment of mycosis fungoides cutaneous T-cell lymphoma (MF-CTCL) and able to sign an informed consent form without assistant from others.
Guitart, JoanGuitart, Joan
  • Map it 676 North St. Clair
    Chicago, IL
NCT02296164 STU00200362
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Serrano, Linda 312 695 6786
The Effect of Topical Anesthetic using Lidocaine 2.5%/Prilocaine 2.5% versus Lidocaine 7%/Tetracaine 7% Cream on Patients’ Pain and Operative Experience During Treatment With Q-Switched 532nm Laser
The purpose of this research is to compare the pain prevention of Lidocaine 2.5%/Prilocaine 2.5% topi…
The purpose of this research is to compare the pain prevention of Lidocaine 2.5%/Prilocaine 2.5% topical anesthetic (LPTA) versus Lidocaine 7%/Tetracaine 7% topical anesthetic (LTTA) when applied to the skin before a laser photorejuvenation treatment.
You are a woman with moderate lentigines (commonly known as “brown spots” or “age spots”) and/or photodamage (sun damage) on your skin and may be interested in a cosmetic (to improve appearance) facial procedure known as laser photorejuvenation (repairing of sun damage). We expect that you will be in this research study for up to 2 hours, which will involve 1 visit to the study site.
Alam, MuradAlam, Murad
  • Map it 676 North St. Clair
    Chicago, IL
NCT02427724 STU00200401
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Samuelson, Emily 312 695 4761
A comparison of interventions to teach patients skin self-examination: Project Skin Watch
Project Skin Watch is a National Cancer Institute sponsored clinical research educational study that aims to teach patients and their skin check partners how to conduct skin self-examinations and promote early d…
Project Skin Watch is a National Cancer Institute sponsored clinical research educational study that aims to teach patients and their skin check partners how to conduct skin self-examinations and promote early detection of melanoma. People will learn the skills need to do the skin check online and complete online surveys three times in 18 months. People will receive $25 compensation for each completed survey. From 2011-2016, Dr. Robinson’s research team developed a skills training program that was used by melanoma patients and their skin check partners to assess their own moles for change. Patients and their partners were trained in the doctor’s office and successfully used this system. Now we want to find out if patients and their skin check partners can learn the skills online.
-Must have had a melanoma (Stage 0 – 2B)
-Must be between the ages of 18 and 70.
-Must be able to see to read a newspaper.
-Must have a spouse, friend, or relative that is willing to be your skin check partner in the study, to help you check the difficult areas to see on the body like your back.
-Must be at least six weeks after surgery, and within 3 years of being told you had a melanoma.
Robinson, June KRobinson, June K
  • Map it 676 North St. Clair
    Chicago, IL
STU00201983
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Nodal, Mercedes 312 926 7459
Finasteride Treatment of Severe Nodulocystic Acne
Study duration: 12 week-long trial, 2:1 ratio of active vs. placebo controlled
18-35 years old, males only, a minimum of 10 nodules on the face and/or the trunk (nodule=10mm or more in diameter)
Schlosser, Bethanee JSchlosser, Bethanee J
  • Map it 676 North St. Clair
    Chicago, IL
NCT02502669 STU00201871
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Florek, Aleksandra 312 695 3613
AAD-PEPR: Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments
The purpose of this study is to validate patient-reported outcomes (PRO) measures in three existing asthma intervention trials as well as a large group of itch-specific pediatric skin conditions, primarily focusing on a…
The purpose of this study is to validate patient-reported outcomes (PRO) measures in three existing asthma intervention trials as well as a large group of itch-specific pediatric skin conditions, primarily focusing on atopic dermatitis (AD, or eczema). The study will look at how well Patient Reported Outcomes Measurement Information System (PROMIS) tools uncover meaningful changes in disease status as well as build a list of items relating to pediatric skin diseases and a PRO model for signs and symptoms of skin disease.
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
STU00202292
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Ibler, Erin 312 695 2203
LEO 124249 Ointment in the Treatment of Alopecia Areata
The purpose of this study is to evaluate whether the investigational drug, LEO 124249 ointment, is effective and safe to use twice daily for 12 weeks for the treatment of alopecia areata
Moderate to severe scalp alopecia areata (currently enrolling patchy type alopecia with >30% hair loss). Ages 18-65. Must be willing to be off other alopecia treatments.
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
NCT02561585 STU00202193
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Ibler, Erin 312 695 2203
A Study of Baricitinib (LY3009104) in Participants With Moderate-to-Severe Atopic Dermatitis
The purpose of this study is to evaluate the safety and effectiveness of baricitinib in moderate-to-severe atopic dermatitis.
18 and older and diagnosed with moderate-severe atopic dermatitis. Study Duration: 6 months, study visits approximately 1/month
Silverberg, JonathanSilverberg, Jonathan
  • Map it 676 North St. Clair
    Chicago, IL
NCT02576938 STU00202196
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Ibler, Erin 312 695 2203
(CIRB) A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of IMO-8400 in Patients with Dermatomyositis
Dermatomyositis is a rare, progressively debilitating disorder that affects the muscle (causing weakness) and skin (causing a rash) in most affected patients. Additionally, it can also in…
Dermatomyositis is a rare, progressively debilitating disorder that affects the muscle (causing weakness) and skin (causing a rash) in most affected patients. Additionally, it can also involve multiple bodily systems including the lungs, joints, gut and heart. The purpose of this study is to learn more about how safe and effective IMO-8400 is, including what impact it may have on the cutaneous (skin) manifestations of dermatomyositis, how well the body tolerates IMO-8400, what the body does to IMO-8400, and what IMO-8400 does to the body in adult patients with dermatomyositis with active skin and muscle disease who are not well controlled on current therapy.
Laumann, Anne ELaumann, Anne E
  • Map it 676 North St. Clair
    Chicago, IL
NCT02612857 STU00202049
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Hagstrom, Erika 312 695 4625
P3 Study in Acne Comparing Once Daily SB204 and Vehicle
The purpose of the study is to evaluate an investigational medication for acne vulgaris on the face. Acne vulgaris is a common skin condition that consists of blackheads, whiteheads, pimples, and sometimes deeper lumps called nodules or cysts. T…
The purpose of the study is to evaluate an investigational medication for acne vulgaris on the face. Acne vulgaris is a common skin condition that consists of blackheads, whiteheads, pimples, and sometimes deeper lumps called nodules or cysts. The study will last approximately 3 months. Qualified participants will receive related medical examinations and study medication at no cost, and may be eligible for compensation for their time and travel.
Healthy males or females 12 years of age and older, have moderate to severe facial acne, have at least 20 pimples, are available for up to 6 visits to the research clinic, are willing to apply investigational medication or placebo for 12 weeks, and are willing to not use any other acne treatment during the study.
Schlosser, Bethanee JSchlosser, Bethanee J
  • Map it 676 North St. Clair
    Chicago, IL
NCT02672332 STU00202509
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acne

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Florek, Aleksandra 312 695 3613
A Dose-Finding Study of GSK2894512 Cream in Subjects With Atopic Dermatitis (AD)
This study will evaluate the efficacy and safety of two concentrations and two application frequencies (once a day and twice a day) of GSK2894512 cream for the topical treatment in adolescent and adult subjects with atop…
This study will evaluate the efficacy and safety of two concentrations and two application frequencies (once a day and twice a day) of GSK2894512 cream for the topical treatment in adolescent and adult subjects with atopic dermatitis.
12 to 18; 18 and older
Diagnosed with moderate atopic dermatitis
Study Duration: 5 months--weekly visits for 3 weeks then monthly visits
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
NCT02564055 STU00202962
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Ibler, Erin 312 695 2203
Defining the Skin and Blood Biomarkers of Ichthyosis
Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper…
Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this disease is required to develop better treatments. There are different types of cells and cell-produced signals (biomarkers) that are being studied in order to help find these new treatments. Looking at biomarkers has been successful in helping us to understand other skin disorders better. The purpose of this study is to determine which blood and skin biomarkers characterize ichthyosis in children.
Subjects (1 year to 60 years of age) with Autosomal Recessive Congenital Ichthyosis (ARCI), which includes lamellar Ichthyosis, Netherton Syndrome, or other ichthyosis subtypes will be enrolled.
Healthy control subjects will be enrolled for either a blood sample or skin sample, and/or tape strip samples.
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Road
    Northbrook, IL
STU00203051
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Huynh, Thy 312 227 6486
Joint Complaints in Children with Harlequin Ichthyosis: A Study to Assess for Comorbidity
The goal of this study is to understand the pattern of joint pain and what pain management options or treatments have worked for individuals with joint disease related to Harlequin Ichthyosis (HI). Participatio…
The goal of this study is to understand the pattern of joint pain and what pain management options or treatments have worked for individuals with joint disease related to Harlequin Ichthyosis (HI). Participation in the study will involve completing a one-time survey administered through letter mailing, emailing, link using an online survey, or in person at the Lurie Children’s Dermatology Clinic. The survey will take about 15-30 minutes.
Confirmed diagnosis of Harlequin Ichthyosis (HI) and have complaints of joint pain, difficulty walking, swelling or other similar issues with your muscles and bones.
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Road
    Northbrook, IL
STU00203185
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Huynh, Thy 312 227 6486
Defining The Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
Atopic dermatitis (AD), also called eczema, is a disease in which the skin is dry and scaly with severe itching that may continue despite treatment. A deeper understanding of this disease is required to develop new and better treat…
Atopic dermatitis (AD), also called eczema, is a disease in which the skin is dry and scaly with severe itching that may continue despite treatment. A deeper understanding of this disease is required to develop new and better treatments. There are different types of cells and cell-produced signals (biomarkers) that have been found in adults with AD. Nevertheless, there may be significant differences between AD in children versus adults. The purpose of this study is to determine which blood and skin biomarkers characterize AD in children by looking at the blood and skin biomarkers of children with AD and children without AD.
This study will enroll children ages 0 months to 17 years to collect blood, skin, saliva and tape strip samples in order to look at biomarkers related to AD. Children who have or have not been diagnosed with AD or an atopic condition, such as allergies or asthma.
Paller, AmyPaller, Amy
  • Map it 676 North St. Clair
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Road
    Northbrook, IL
STU00203272
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For more information on this study please contact us:

Huynh, Thy 312 227 6486