Division of Reproductive Biology Research

Eugene Y. Xu, PhD, Laboratory Staff

Email: e-xu@northwestern.edu
Telephone: (312) 503-0842
Fax: (312) 908-5603

Mike VanGompel, BA
Graduate Student
Mike joined Dr. Xu's lab in 2007. He received his BA in Biology and Science in Human Culture from Northwestern University in 2004. Before enrolling in Northwestern University's IGP program, Mike worked as a lab tech at Children's Memorial Hospital developing a knockout mouse model of a non-coding RNA involved in brain development. He is currently studying the conserved RNA-binding Boule and its role in spermatogenesis and male infertility.

Publications

• Xu, E. Y., D. Lee, A. Klebes, P. J. Turek, T. Kornberg and  R. Reijo Pera (2003) Human BOULE rescues the meiotic defects in  infertile flies  Human Molecular Genetics.  Vol 12(2):169-175.
• Wu, C.-I. and E. Y. Xu (2003)  Sexual antagonism and X inactivation- the SAXI hypothesis. Trends in Genetics 19(5): 243-7     
• Xu, E. Y., F. Moore, R. Reijo Pera (2001) From the cover: A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. PNAS Vol 98:7414-7419
• Joyce Y. Tung, C. Marc Luetjens, Joachim Wistuba, Eugene Y. Xu, Renee A. Reijo Pera, Jörg Gromoll  (2005) Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ  Genes, Development and Evolution  accepted
• C. Marc Luetjens, E. Y. Xu, Renee A. Reijo Pera, Axel Kamischke, Eberhard Nieschlag, Jörg Gromoll (2004)  Association of meiotic arrest in infertile men and lack of BOULE protein expression.  J. Clinical Endocrinology and Metabolism 89(4):1926-33    
• Y.-M. Kuo, J. Duncan, S. Westaway,H. Yang, G. Nune, E. Y. Xu, S. Hayflick, and J. Gitschier (2004)  Deficiency in pantothenate kinase 2 in a mouse model for Hallervorden-Spatz Syndrome leads to retinal degeneration and azoospermia  Human Molecular Genetics 14(1):49-57    
• Wu, C.-I., H. Hollocher, D.J. Begun, C. F. Aquadro, E. Y. Xu (formerly as Y. Xu) and Mao-Lien Wu (1995) Sexual isolation in Drosophila melanogaster: A possible case of incipient speciation.  PNAS  92: 2519-2523

• Li, K., E. Y. Xu, J.Cecil, R.R. Turner, T. L. Megraw and T.C. Kaufman (1998) Drosophila centrosomin protein is required for male meiosis and assembly of the flagellar axoneme J. Cell Biology 141:455-467