Division of Reproductive Biology Research
Bulun Laboratory

Laboratory Telephone: (312) 503-4759
Fax: (312) 503-0095

Recent Publications 

• Cheng YH, AG Imir, V Fencki, MB Yilmaz and Bulun SE:  Stromal cell of endometriosis fail to produce paracrine factors that induce epithelial 17b-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism.  Am J Obstet Gynecol.  196:391.e1-7; discussion 391.e7-8 (2007).
• Su E, YH Cheng, R Chatterton, Z Lin, P Yin, S Reierstad, J Innes and SE Bulun: Regulation of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD@) in human placental endothelial cells. Biol Reprod. 77:51725 (2007).
• Imir AG, Z Lin, P Yin, S Deb, MB Yilmaz, M Cetin, A Cetin, and SE Bulun: Aromatase expression in uterine leiomyomata is regulated primarily by proximal promoters I.3/II. J Clin Endocrinol Metab. 92:1979-1982 (2007).
• Lin Z, Reierstad S, Huang C and SE Bulun: Novel estrogen receptor-α binding sites and estradiol target genes identified by chromatin immunoprecipitation-cloning in breast cancer. Cancer Res. 67:5017-5024 (2007).
• Xue Q, Lin Z, Yin P, Milad MP, Cheng YH, Confino E, Reierstad S and SE Bulun: Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5'CpG island in endmetriosis. J Clin Endocrino Metab. 92:3261-7 (2007).
• Bulun SE, Chen D, Lu M, Zhao H, Cheng YH, Demura M, Yilmaz MB, Martin R, Utsunomiya H, Thung S, Su E, Marsh EE, Hakim A, Yin P, Ishikawa H, Amin S, Imir G, Gurates B, Attar E, Reierstad S, Innes J and Z Lin: Aromatase excess in cancers of breast, endometrium and ovary. J Steroid Biochem Mol Biol. 106:81-96 (2007).
• Anderson H, Bulun SE, Smith I, Dowsett M: Predictors of response to aromatase inhibitors. J Steroid Biochem Mol Biol. 106-4954 (2007).
• Chen D, Reierstad S, Z Lin, M Lu, C Brooks, N Li, J Innes and SE Bulun: PGE2 induces breast cancer-related aromatase promoters via activation of p38 and JNK in adipose fibroblasts. Cancer Res. 67:8914-22 (2007).
• Xue, Q, Lin Z Cheng YH, Yin P, Reierstad S, Marsh EE, Milad MP, Confino E, Innes J and SE Bulun: Promoter methylation regulates estrogen receptor 2 in endometrium and endometriosis. Biol Reprod. 77:681-687 (2007).
• Demura M, Martin RM, Shozu M, Sebastian S, Takayama K, Hsu WT, Schultz RA, Neely K, Bryant M, Mendonca BB, Hanaki K, Kanzaki S, Rhoads DB, Misra M and SE Bulun: Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP 19 (aromatase) gene. Hum Mol Genet. 16:2529-41 (2007).
• Pin Y, Lin Z, Cheng YH, Marsh EE, Utsunomiya H, Ishikawa H, Xue Q, Reierstad S, Innes J, Kim JJ, Xu EY and SE Bulun: Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. J Clin Endocrinol Metab. 92:4459-66 (2007).
• Demura M and SE Bulun: CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activity. Mol Cell Endocrinol. 283:127-32 (2008).
• Ishikawa H, Fencki V, Marsh EE, Yin P, Chen D, Cheng YH, Reierstad S, Lin Z and SE Bulun: CCAAT/Enhancer binding protein beta (C/EBPβ) regulates aromatase expression via multiple and novel DNA sequences in uterine leiomyoma. J Clin Endocrinol Metab. 93:981-91 (2008).
• Utsunomiya H, Cheng YH, Lin Z, reierstad S, Yin P, Attar E, Xue Q, Imir AG, Thung S, Suzuki T, Sasano H, Kim JJ, Yaegashi N and SE Bulun: Upstream stimulatory factors regulate steroidogenic factor-1 expression in endometriosis. Mol Endocrinol. 22:904-14 (2008).