Publications and Grants

Publications | Grants

Publications

Catch up on the latest published findings from our members:

Matthew J. Robson, Meagan A. Quinlan, Kara Gross Margolis, Paula A. Gajewski-Kurdziel, Jeremy Veenstra-VanderWeele, Michael D. Gershon, D. Martin Watterson, and Randy D. Blakely. p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proceedings of the National Academy of Sciences Oct 2018, 115 (43) E10245-E10254; DOI: 10.1073/pnas. PMCID: PMC6205438

Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P. A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability. Biol Psychiatry. 2018 Mar 15;83(6):499-508. doi: 10.1016/j.biopsych.2017.10.024. Epub 2017 Nov 7. PubMed PMID: 29241584; PubMed Central PMCID: PMC5809265.

Forrest MP, Parnell E, Penzes P. Dendritic structural plasticity and neuropsychiatric disease. Nat Rev Neurosci. 2018 Mar 16;19(4):215-234. doi: 10.1038/nrn.2018.16. Review. PubMed PMID: 29545546.

Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. J Neurosci. 2017 Nov 15;37(46):11127-11139. doi: 10.1523/JNEUROSCI.1153-17.2017. Epub 2017 Oct 13. PubMed PMID: 29030434; PubMed Central PMCID: PMC5688522.

Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P. CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Mol Psychiatry. 2018 Apr 2. doi: 10.1038/s41380-018-0027-3. [Epub ahead of print] PubMed PMID: 29610457.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10. PubMed PMID: 28803920; PubMed Central PMCID: PMC5591074.

MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. Am J Psychiatry. 2017 Jun 1;174(6):586-594. doi: 10.1176/appi.ajp.2017.16070814. Epub 2017 Mar 31. PubMed PMID: 28359200; PubMed Central PMCID: PMC5800878.

Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest M, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P. Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins. J Neurosci. 2017 Oct 13. pii: 1153-17.

Blizinsky KD, Diaz-Castro B, Forrest MP, Schürmann B, Bach AP, Martin-de-Saavedra MD, Wang L, Csernansky JG, Duan J, Penzes P. Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub. Proc Natl Acad Sci U S A. 2016 Jul26;113(30):8520-5. doi: 10.1073/pnas.1607014113. Epub 2016 Jul 11. PubMed PMID:27402753; PubMed Central PMCID: PMC4968749.

Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proc Natl Acad Sci U S A. 2015May 12;112(19):6176-81. doi: 10.1073/pnas.1423205112. Epub 2015 Apr 27. PubMedPMID: 25918374; PubMed Central PMCID: PMC4434727.

Gao R, Penzes P. Common mechanisms of excitatory and inhibitory imbalance inschizophrenia and autism spectrum disorders. Curr Mol Med. 2015;15(2):146-67.Review. PubMed PMID: 25732149; PubMed Central PMCID: PMC4721588.

Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B,Myczek K, Radulovic J, Swanson GT, Penzes P. Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergicsynapses. Neuron. 2014 Oct 22;84(2):399-415. doi: 10.1016/j.neuron.2014.10.010. Epub 2014 Oct 22. PubMed PMID: 25374361; PubMed Central PMCID: PMC4223651.

Penzes P, Buonanno A, Passafaro M, Sala C, Sweet RA. Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders. J Neurochem. 2013 Jul;126(2):165-82. doi: 10.1111/jnc.12261. Epub 2013 May 22. Review. PubMed PMID: 23574039; PubMed Central PMCID: PMC3700683.

Srivastava DP, Woolfrey KM, Jones KA, Anderson CT, Smith KR, Russell TA, LeeH, Yasvoina MV, Wokosin DL, Ozdinler PH, Shepherd GM, Penzes P. An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol. 2012;10(6):e1001350. doi: 10.1371/journal.pbio.1001350. Epub 2012 Jun 26. PubMed PMID: 22745599; PubMed Central PMCID: PMC3383751.

Srivastava DP, Woolfrey KM, Penzes P. Analysis of dendritic spine morphologyin cultured CNS neurons. J Vis Exp. 2011 Jul 13;(53):e2794. doi: 10.3791/2794. PubMed PMID: 21775964; PubMed Central PMCID: PMC3196192.

Penzes P, Cahill ME, Jones KA, VanLeeuwen JE, Woolfrey KM. Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci. 2011 Mar;14(3):285-93. doi: 10.1038/nn.2741. Review. PubMed PMID: 21346746; PubMed Central PMCID: PMC3530413.

Penzes P, Woolfrey KM, Srivastava DP. Epac2-mediated dendritic spine remodeling: implications for disease. Mol Cell Neurosci. 2011 Feb;46(2):368-80. doi: 10.1016/j.mcn.2010.11.008. Epub 2010 Nov 27. Review. PubMed PMID: 21115118; PubMed Central PMCID: PMC3031158.

Nomura T, Musial TF, Marshall JJ, Zhu Y, Remmers CL, Xu J, Nicholson DA, Contractor A. Delayed Maturation of Fast-Spiking Interneurons is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome. J Neurosci. 2017 Oct 16. pii: 2893-16. doi: 10.1523/JNEUROSCI.2893-16.2017. [Epub ahead of print] PubMed PMID: 29038238.

He Q, Nomura T, Xu J, Contractor A. The developmental switch in GABA polarity is delayed in fragile X mice. J Neurosci. 2014 Jan 8;34(2):446-50. doi: 10.1523/JNEUROSCI.4447-13.2014. PubMed PMID: 24403144.

Till SM, Wijetunge LS, Seidel VG, Harlow E, Wright AK, Bagni C, Contractor A, Gillingwater TH, Kind PC. Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Hum Mol Genet. 2012 May 15;21(10):2143-56. doi: 10.1093/hmg/dds030. Epub 2012 Feb 9. PubMed PMID:22328088.

Harlow EG, Till SM, Russell TA, Wijetunge LS, Kind P, Contractor A. Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice. Neuron. 2010 Feb 11;65(3):385-98. doi: 10.1016/j.neuron.2010.01.024. PubMed PMID: 20159451; PubMed Central PMCID: PMC2825250.

Woolfrey KM, Srivastava DP, Photowala H, Yamashita M, Barbolina MV, Cahill ME, Xie Z, Jones KA, Quilliam LA, Prakriya M, Penzes P. Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci. 2009 Oct;12(10):1275-84. doi: 10.1038/nn.2386. Epub 2009 Sep 6. PubMed PMID: 19734897; PubMed Central PMCID: PMC2754861.

Torkamani A, Bersell K, Jorge BS, Bjork RL Jr, Friedman JR, Bloss CS, Cohen J, Gupta S, Naidu S, Vanoye CG, George AL Jr, Kearney JA. De novo KCNB1 mutations in epileptic encephalopathy. Ann Neurol. 2014 Oct;76(4):529-540. doi: 10.1002/ana.24263. Epub 2014 Sep 19. PubMed PMID: 25164438; PubMed Central PMCID: PMC4192091.

Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH. Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry. 2003 Feb;8(2):186-94. PubMed PMID: 12610651.

Carvill G, Helbig I, Mefford H. CHD2-Related Neurodevelopmental Disorders. 2015 Dec 10. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017. Available from http://www.ncbi.nlm.nih.gov/books/NBK333201/ PubMed PMID: 26677509.

Coe BP, Witherspoon K, Rosenfeld JA, van Bon BW, Vulto-van Silfhout AT, Bosco P, Friend KL, Baker C, Buono S, Vissers LE, Schuurs-Hoeijmakers JH, Hoischen A, Pfundt R, Krumm N, Carvill GL, Li D, Amaral D, Brown N, Lockhart PJ, Scheffer IE, Alberti A, Shaw M, Pettinato R, Tervo R, de Leeuw N, Reijnders MR, Torchia BS, Peeters H, O'Roak BJ, Fichera M, Hehir-Kwa JY, Shendure J, Mefford HC, Haan E, Gécz J, de Vries BB, Romano C, Eichler EE. Refining analyses of copy number variation identifies specific genes associated with developmental delay. Nat Genet. 2014 Oct;46(10):1063-71. doi: 10.1038/ng.3092. Epub 2014 Sep 14. PubMed PMID: 25217958; PubMed Central PMCID: PMC4177294.

Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS One. 2013 Dec 3;8(12):e80737. doi: 10.1371/journal.pone.0080737. eCollection 2013. PubMed PMID: 24312498; PubMed Central PMCID: PMC3849077.

Carvill GL, Mefford HC. Microdeletion syndromes. Curr Opin Genet Dev. 2013 Jun;23(3):232-9. doi: 10.1016/j.gde.2013.03.004. Epub 2013 May 9. Review. PubMed PMID: 23664828.

O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A, Lee C, Ankenman K, Munson J, Hiatt JB, Turner EH, Levy R, O'Day DR, Krumm N, Coe BP, Martin BK, Borenstein E, Nickerson DA, Mefford HC, Doherty D, Akey JM, Bernier R, Eichler EE, Shendure J. Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science. 2012 Dec 21;338(6114):1619-22. doi: 10.1126/science.1227764. Epub 2012 Nov 15. PubMed PMID: 23160955; PubMed Central PMCID: PMC3528801.

Liu S, Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD 2nd, Lu W, Traynelis SF, Roche KW. A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density. J Neurosci. 2017 Apr 12;37(15):4093-4102. doi: 10.1523/JNEUROSCI.0827-16.2017. Epub 2017 Mar 10. PubMed PMID: 28283559; PubMed Central PMCID: PMC5391683.

Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron. 2017 Aug 16;95(4):896-913.e10. doi: 10.1016/j.neuron.2017.07.040. PubMed PMID: 28817804; PubMed Central PMCID: PMC5563082.

Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J. The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 2015 Aug 19;87(4):764-80. doi: 10.1016/j.neuron.2015.08.007. PubMed PMID: 2629110; PubMed Central PMCID: PMC4692362.

Shepherd GM, Katz DM. Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met. Curr Opin Neurobiol. 2011 Dec;21(6):827-33. doi: 10.1016/j.conb.2011.06.006. Epub 2011 Jul 4. Review. PubMed PMID: 21733672; PubMed Central PMCID: PMC3199024.

Shepherd GM. Corticostriatal connectivity and its role in disease. Nat Rev Neurosci. 2013 Apr;14(4):278-91. doi: 10.1038/nrn3469. Review. PubMed PMID: 23511908; PubMed Central PMCID: PMC4096337.

Qiu S, Anderson CT, Levitt P, Shepherd GM. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci. 2011 Apr 13;31(15):5855-64. doi: 10.1523/JNEUROSCI.6569-10.2011. PubMed PMID: 21490227; PubMed Central PMCID: PMC3086026.

Wood L, Gray NW, Zhou Z, Greenberg ME, Shepherd GM. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci. 2009 Oct 7;29(40):12440-8. doi: 10.1523/JNEUROSCI.3321-09.2009. PubMed PMID: 19812320; PubMed Central PMCID: PMC2782478.

PlatzerK, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR. GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects. J Med Genet. 2017 Jul;54(7):460-470. doi: 10.1136/jmedgenet-2016-104509. Epub 2017 Apr 4. PubMed PMID: 28377535; PubMed Central PMCID: PMC5656050.

Lam WW, Millichap JJ, Soares DC, Chin R, McLellan A, FitzPatrick DR, Elmslie F, Lees MM, Schaefer GB; DDD study, Abbott CM. Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability. Mol Genet Genomic Med. 2016 Apr 3;4(4):465-74. doi: 10.1002/mgg3.219. eCollection 2016 Jul. PubMed PMID: 27441201; PubMed Central PMCID: PMC4947865.

Millichap JG, Yee MM. Dystonia with MPH/Risperidone Combined Therapy for ADHD. Pediatr Neurol Briefs. 2016 Jan;30(1):7. doi: 10.15844/pedneurbriefs-30-1-6. PubMed PMID: 27004141; PubMed Central PMCID: PMC4798857.

Yee MM, Millichap JG. Relationship between Age at Diagnosis of ADHD and ASD. Pediatr Neurol Briefs. 2015 Oct;29(10):78. doi: 10.15844/pedneurbriefs-29-10-5. PubMed PMID: 26933536; PubMed Central PMCID: PMC4747140.

Burgdorf J, Moskal JR, Brudzynski SM, Panksepp J. Rats selectively bred for low levels of play-induced 50 kHz vocalizations as a model for autism spectrum disorders: a role for NMDA receptors. Behav Brain Res. 2013 Aug 15;251:18-24. doi: 10.1016/j.bbr.2013.04.022. Epub 2013 Apr 23. Review. PubMed PMID: 23623884; PubMed Central PMCID: PMC4721229.

Moskal JR, Burgdorf J, Kroes RA, Brudzynski SM, Panksepp J. A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism. Neurosci Biobehav Rev. 2011 Oct;35(9):1982-8. doi: 10.1016/j.neubiorev.2011.06.006. Epub 2011 Jun 28. Review. PubMed PMID: 21718719.

Harmon KM, Cromwell HC, Burgdorf J, Moskal JR, Brudzynski SM, Kroes RA, Panksepp J. Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivation. Dev Psychobiol. 2008 May;50(4):322-31. doi: 10.1002/dev.20294. PubMed PMID: 18393285.

Meng L, Lu L, Murphy KM, Yuede CM, Cheverud JM, Csernansky JG, Dong H. Neuroanatomic and behavioral traits for autistic disorders in age-specific restricted index selection mice. Neuroscience. 2011 Aug 25;189:215-22. doi: 10.1016/j.neuroscience.2011.05.017. Epub 2011 May 26. PubMed PMID: 21624435; PubMed Central PMCID: PMC3150457.

Dager SR, Wang L, Friedman SD, Shaw DW, Constantino JN, Artru AA, Dawson G, Csernansky JG. Shape mapping of the hippocampus in young children with autism spectrum disorder. AJNR Am J Neuroradiol. 2007 Apr;28(4):672-7. PubMed PMID: 17416819.

Zhang Y, Chen M, Qiu Z, Hu K, McGee W, Chen X, Liu J, Zhu L, Wu JY. MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2. Protein Cell. 2016 Jul;7(7):489-500. doi: 10.1007/s13238-016-0272-7. Epub 2016 Jun 1. PubMed PMID: 27245166; PubMed Central PMCID: PMC4930766.

Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR. GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects. J Med Genet. 2017 Jul;54(7):460-470. doi: 10.1136/jmedgenet-2016-104509. Epub 2017 Apr 4. PubMed PMID: 28377535; PubMed Central PMCID: PMC5656050.

Berg AT, Dobyns WB. Progress in autism research and postgenomic studies - Authors' reply. Lancet Neurol. 2016 Feb;15(2):136-137. doi: 10.1016/S1474-4422(15)00403-2. Epub 2016 Jan 12. PubMed PMID: 28463119.

Berg AT, Dobyns WB. Progress in autism and related disorders of brain development. Lancet Neurol. 2015 Nov;14(11):1069-70. doi: 10.1016/S1474-4422(15)00048-4. Epub 2015 Apr 16. PubMed PMID: 25891008.

Fisher B, Dezort C, Nordli DR, Berg AT. Routine developmental and autism screening in an epilepsy care setting. Epilepsy Behav. 2012 Aug;24(4):488-92. doi: 10.1016/j.yebeh.2012.06.006. Epub 2012 Jul 10. PubMed PMID: 22789633.

Berg AT, Plioplys S. Epilepsy and autism: is there a special relationship? Epilepsy Behav. 2012 Mar;23(3):193-8. doi: 10.1016/j.yebeh.2012.01.015. Epub 2012 Feb 29. Review. PubMed PMID: 22381386; PubMed Central PMCID: PMC3307824.

Berg AT, Plioplys S, Tuchman R. Risk and correlates of autism spectrum disorder in children with epilepsy: a community-based study. J Child Neurol. 2011 May;26(5):540-7. doi: 10.1177/0883073810384869. Epub 2011 Mar 18. PubMed PMID: 21421903; PubMed Central PMCID: PMC3085568.

Grants

Synaptic and Dendritic Dysfunction in Psychiatric Disorders

Postsynaptic Roles of Ankyrin

Postsynaptic Functions of Neuronal Adhesion Molecules: Focus on CNTNAP2

Role of PCDH12 in Neuronal Circuit Formation During Brain Development and Disease

Regulation of cortical critical periods in a mouse model of autism