Publications and Grants

Publications | Grants

Publications

  1. Ramamurthy A, Bandouil MD, Aluru L, Joshi O, Yoon E, Bodkin N, Cheng JZ, Biar CG, Calhoun JD, Carvill GL  Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene FOXG1.  Nat Commun  2026 Jul 21;17(1). pii:6965
  2. Dos Santos M, Forrest MP, Bomba-Warczak E, Dey S, Parnell E, Christiansen JM, Edassery SL, Yang K, Hayes LN, Coughlin JM  et al.  Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model.  Neuron  2026 Jun 17;114(12):2128-2147.e10. doi:10.1016/j.neuron.2026.02.004
  3. Nomura T, Morton C, Marshall JJ, Contractor A  Exaggerated NMDA Receptor-Primed Metaplasticity via SK Channel Dysregulation in Fmr1 Knockout Mice.  J Neurosci  2026 Jun 03;46(22). pii:e1653252026
  4. Castillon CCM, Otsuka S, Armstrong JN, Contractor A  Subregional activity in the dentate gyrus is amplified during elevated cognitive demands.  Elife  2026 May 14;15. pii:RP109611
  5. Golinski SR, Soriano K, Briegel AC, Burke MC, Tang S, Carvill GL, Sherrill E, Lentucci C, Yu TW, Nakayama T  et al.  RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death.  Nat Commun  2026 Apr 29;17(1). pii:5864
  6. Monteiro R, Dunn JT, Rodriguez G, Fisher DW, Dong H  Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice.  Sci Rep  2026 Apr 25;16(1). pii:19688
  7. Richevaux L, Fischer R, Baid M, Shepherd GMG  Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.  J Neurosci  2026 Mar 18;46(11). pii:e1019252026
  8. Tam SB, Waldeck NJ, Wright M, Mojsilovic-Petrovic J, Baker EM, Kiskinis E, Bass J, Kalb RG  A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration.  Life Sci Alliance  2026 Mar;9(3). pii:e202503508
  9. Alessandrini F, Wright M, Kurosaki T, Perloff OS, Ngo M, Kofler JK, Donnelly CJ, Maquat LE, Kiskinis E  TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS.  Neuron  2026 Feb 18;114(4):640-660.e10. doi:10.1016/j.neuron.2025.11.001
  10. Rao NR, Santiago-Marrero I, DeGulis O, Nomura T, Goyal K, Lee S, Hark TJ, Dynes JC, Dexter EX, Dulewicz M  et al.  Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.  Sci Transl Med  2026 Feb 11;18(836):eadp3984. doi:10.1126/scitranslmed.adp3984
  11. Miller-Hansen AJ, Lerner TN  Dopamine's secret agent: serotonin.  Trends Neurosci  2026 Feb;49(2):77-79. doi:10.1016/j.tins.2025.12.008
  12. Bidwell JS, Vanoye CG, Desai RR, Berg AT, George AL  Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction.  Epilepsia Open  2026 Feb;11(1):190-199. doi:10.1002/epi4.70192
  13. Marshall JJ, Xu J, Yeh NH, Yun S, Nomura T, Armstrong JN, Parker J, Contractor A  Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output.  Elife  2026 Jan 27;13. pii:RP98122
  14. Rodriguez G, Zhao X, Neugebauer NM, Meltzer HY, Dong H  Impact of 5-HT7 receptor gene deletion on memory and affective behaviors in young and aged mice.  Neuroscience  2026 Jan 09;592:191-200. doi:10.1016/j.neuroscience.2025.11.035
  15. Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT  et al.  TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.  Nat Neurosci  2025 Dec;28(12):2476-2492. doi:10.1038/s41593-025-02096-w
  16. Loomba N, Patel S  Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation.  Nat Rev Neurosci  2025 Nov;26(11):677-697. doi:10.1038/s41583-025-00961-y
  17. Báldi R, Muthuswamy S, Yasmin F, Quadir S, Zaidi D, Kwon M, Kandil I, Johnson K, Loomba N, Patel S  Synaptic organization and associative learning-related activity of basolateral amygdala interneurons.  Cell Rep  2025 Oct 28;44(10):116295. doi:10.1016/j.celrep.2025.116295
  18. Dey S, Quintanilla C, Bitlis D, Gautam M, Ozdinler PH, Martina M  Cell Type-Specific Alterations in Excitability and Inhibition of Upper Motor Neurons in AlsinKO Mice, a Model of Juvenile Onset ALS.  J Neurosci  2025 Sep 24;45(39). pii:e2409242025
  19. Rakotomamonjy J, Davies D, Valencia X, Son O, Gomez-Maqueo X, Guemez-Gamboa A  Epilepsy Associated Gene, Pcdh7, Is Dispensable for Brain Development in Mice.  Genes (Basel)  2025 Aug 21;16(8). pii:985
  20. Parnell E, Christiansen JM, Spratt MA, Ruiz S, Macdonald ML, Penzes P, Sweet RA, Grubisha MJ  Oligodendrocyte myelin glycoprotein impairs dendritic arbors via schizophrenia risk gene Trio.  Neurobiol Dis  2025 Jul;211:106928. doi:10.1016/j.nbd.2025.106928
  21. Rosas-Vidal LE, Naskar S, Mayo LM, Perini I, Masroor R, Altemus M, Ramos-Medina L, Zaidi SD, Engelbrektsson H, Jagasia P  et al.  Prefrontal correlates of fear generalization during endocannabinoid depletion.  J Clin Invest  2025 Jun 02;135(11). pii:e179881
  22. Piña Novo D, Gao M, Fischer R, Richevaux L, Yu J, Barrett JM, Shepherd GMG  Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.  Elife  2025 May 19;14. pii:RP105112
  23. Lopez GC, Van Camp LD, Kovaleski RF, Schaid MD, Sherathiya VN, Cox JM, Lerner TN  Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning.  Curr Biol  2025 May 19;35(10):2433-2443.e5. doi:10.1016/j.cub.2025.04.006
  24. Knox AT, Thompson CH, Scott D, Abramova TV, Stieve B, Freeman A, George AL  Genotype-function-phenotype correlations for SCN1A variants identified by clinical genetic testing.  Ann Clin Transl Neurol  2025 Mar;12(3):499-511. doi:10.1002/acn3.52297
  25. Yoshikawa A, Li J, Alliey-Rodriguez N, Meltzer HY  Genetic markers of early response to lurasidone in acute schizophrenia.  Pharmacogenomics J  2025 Feb 20;25(2):3. pii:3
  26. Tang S, Stamberger H, Calhoun JD, Weckhuysen S, Carvill GL  Antisense oligonucleotides modulate aberrant inclusion of poison exons in SCN1A-related Dravet syndrome.  JCI Insight  2025 Feb 13;10(7). pii:e188014
  27. Novakovic MM, Prakriya M  Calcium signaling at the interface between astrocytes and brain inflammation.  Curr Opin Neurobiol  2025 Feb;90:102940. doi:10.1016/j.conb.2024.102940
  28. Yoon S, Penzes P  Roles of ANK2/ankyrin-B in neurodevelopmental disorders: Isoform functions and implications for autism spectrum disorder and epilepsy.  Curr Opin Neurobiol  2025 Feb;90:102938. doi:10.1016/j.conb.2024.102938
  29. Korshunov KS, Prakriya M  Store-Operated Calcium Channels in the Nervous System.  Annu Rev Physiol  2025 Feb;87(1):173-199. doi:10.1146/annurev-physiol-022724-105330
  30. Kim HR, Dey S, Sekerkova G, Martina M  μ-Opioid Receptor Modulation of the Glutamatergic/GABAergic Midbrain Inputs to the Mouse Dorsal Hippocampus.  J Neurosci  2024 Oct 23;44(43). pii:e0653242024
  31. Borjas NC, Anstötz M, Maccaferri G  Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons.  J Physiol  2024 Sep;602(17):4195-4213. doi:10.1113/JP286679
  32. Hawkins NA, Speakes N, Kearney JA  Fine mapping and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8.  Mamm Genome  2024 Sep;35(3):334-345. doi:10.1007/s00335-024-10046-3
  33. McClarty BM, Rodriguez G, Dong H  Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice.  Brain Res  2024 Aug 15;1837:148951. doi:10.1016/j.brainres.2024.148951
  34. Berg AT, Thompson CH, Myers LS, Anderson E, Evans L, Kaiser AJE, Paltell K, Nili AN, DeKeyser JL, Abramova TV  et al.  Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders.  Brain  2024 Aug 01;147(8):2761-2774. doi:10.1093/brain/awae125
  35. Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN  Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice.  Mol Psychiatry  2024 Aug;29(8):2372-2388. doi:10.1038/s41380-024-02493-w
  36. Sekerková G, Kilic S, Cheng YH, Fredrick N, Osmani A, Kim H, Opal P, Martina M  Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia.  Neurobiol Dis  2024 Jun 01;195:106492. doi:10.1016/j.nbd.2024.106492
  37. Vanoye CG, Abramova TV, DeKeyser JM, Ghabra NF, Oudin MJ, Burge CB, Helbig I, Thompson CH, George AL  Molecular and cellular context influences SCN8A variant function.  JCI Insight  2024 May 21;9(12). pii:e177530
  38. Kahl M, Xu Z, Arumugam S, Edens B, Fischietti M, Zhu AC, Platanias LC, He C, Zhuang X, Ma YC  m6A RNA methylation regulates mitochondrial function.  Hum Mol Genet  2024 May 18;33(11):969-980. doi:10.1093/hmg/ddae029
  39. George AL  Late Sodium Current Promotes Ventricular Arrhythmia in Epilepsy-Related Sudden Death.  JACC Clin Electrophysiol  2024 May;10(5):843-845. doi:10.1016/j.jacep.2024.02.029
  40. Kang SK, Hawkins NA, Thompson CH, Baker EM, Echevarria-Cooper DM, Barse L, Thenstedt T, Dixon CJ, Speakes N, George AL  et al.  Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant.  Neurobiol Dis  2024 May;194:106470. doi:10.1016/j.nbd.2024.106470
  41. Seiler JL, Zhuang X, Nelson AB, Lerner TN  Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression.  Exp Neurol  2024 Apr;374:114693. doi:10.1016/j.expneurol.2024.114693
  42. Schroder AL, Fairbanks-Santana M, Rakotomamonjy J, Guemez-Gamboa A  Quantifying differentiation of progenitor populations using cerebral organoid models for neurodevelopmental disorders.  STAR Protoc  2024 Mar 15;5(1):102904. pii:102904
  43. Rajagopal L, Huang M, Mahjour S, Ryan C, Elzokaky A, Svensson KA, Meltzer HY  The dopamine D1 receptor positive allosteric modulator, DETQ, improves cognition and social interaction in aged mice and enhances cortical and hippocampal acetylcholine efflux.  Behav Brain Res  2024 Feb 29;459:114766. doi:10.1016/j.bbr.2023.114766
  44. Wang YZ, Castillon CCM, Gebis KK, Bartom ET, d'Azzo A, Contractor A, Savas JN  Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication.  Cell Rep  2024 Feb 27;43(2):113680. doi:10.1016/j.celrep.2024.113680
  45. Chi W, Kiskinis E  Integrative analysis of epilepsy-associated genes reveals expression-phenotype correlations.  Sci Rep  2024 Feb 13;14(1):3587. pii:3587
  46. Rao NR, Upadhyay A, Savas JN  Derailed protein turnover in the aging mammalian brain.  Mol Syst Biol  2024 Feb;20(2):120-139. doi:10.1038/s44320-023-00009-2
  47. Kim HR, Long M, Sekerková G, Maes A, Kennedy A, Martina M  Hypernegative GABAA Reversal Potential in Pyramidal Cells Contributes to Medial Prefrontal Cortex Deactivation in a Mouse Model of Neuropathic Pain.  J Pain  2024 Feb;25(2):522-532. doi:10.1016/j.jpain.2023.09.021
  48. Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A  iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.  Nat Commun  2024 Jan 27;15(1):827. pii:827
  49. Holloway AL, Lerner TN  Hidden variables in stress neurobiology research.  Trends Neurosci  2024 Jan;47(1):9-17. doi:10.1016/j.tins.2023.10.006

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