Current Research

Current projects in our laboratory focus on understanding and characterizing circadian disorders such as Advanced and Delayed Sleep Phase Syndrome; using exercise as an intervention to improve sleep and circadian functioning in the elderly; looking at how different wavelengths of light affect melatonin; charting the body’s response to melatonin administration at different times of day; and evaluating medication regimens for Restless Leg Syndrome.

* Zee PC, Manthena P. (2007) The brain's master circadian clock: implications and opportunities for therapy of sleep disorders. Sleep Med Rev. 11(1):59-70. - PubMed

* Barion A, Zee PC. (2007) A clinical approach to circadian rhythm sleep disorders. Sleep Med. 8(6):566-77. - PubMed

* Lu BS, Zee PC. (2006) Circadian rhythm sleep disorders. Chest. 130(6):1915-23. - PubMed

* Pack AI, Zee PC. (2006) The pipeline of investigators for sleep research--a crisis! Sleep. 29(10):1260-1. - PubMed

* Reid KJ, Martinovich Z, Finkel S, Statsinger J, Golden R, Harter K, Zee PC. (2006) Sleep: A Marker of Physical and Mental Health in the Elderly. Am J Geriatr Psychiatry. 14(10): 860-866. - PubMed

* Fahey C, Zee PC. (2006) Circadian Rhythm Sleep Disorders and Phototheraphy. Psychiatr Clin N Am. 29(4): 989-1007. - PubMed

* Zee PC, Turek FW. (2006) Sleep and health: Everywhere and in both directions. Arch Intern Med. 166(16):1686-8. - PubMed

* Roth T, Seiden D, Sainati S, Wang-Weigand S, Zhang J, Zee P. (2006) Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia.Sleep Med. 7(4):312-8. - PubMed

* Manthena P, Zee PC. (2006) Neurobiology of circadian rhythm sleep disorders. Curr Neurol Neurosci Rep. 6(2):163-8. - PubMed

* Benloucif S, Green K, L'Hermite-Balériaux M, Weintraub S, Wolfe LF, Zee PC. (2006) Responsiveness of the aging circadian clock to light. Neurobiol Aging. 27(12):1870-9. - PubMed

* Dawson D, Zee P. (2005) Work hours and reducing fatigue-related risk: good research vs good policy. JAMA. 294(9):1104-6. - PubMed

* Hansen M, Janssen I, Schiff A, Zee PC, Dubocovich ML. (2005) The impact of school daily schedule on adolescent sleep. Pediatrics. 115(6):1555-61. - PubMed

* Benloucif S, Guico MJ, Reid KJ, Wolfe LF, L'Hermite-Balériaux M, Zee PC. (2005) Stability of Melatonin and Temperature as Circadian Phase Markers and Their Relation to Sleep Times in Humans. J Biological Rhythms. 20(2): 178-188. - PubMed

* Jankelowitz L, Reid KJ, Wolfe L, Cullina J, Zee PC, Jain M. (2005) Cystic fibrosis patients have poor sleep quality despite normal sleep latency and efficiency. Chest. 127(5):1593-9. - PubMed

* Reid KJ, Burgess HJ. (2005) Circadian Rhythm Sleep Disorders. Prim Care Clin Office Pract. 32: 449-473. - PubMed

* Mundey K, Benloucif S, Harsanyi K, Dubocovich ML, Zee PC. (2005) Phase-Dependent Treatment of Delayed Sleep Phase Syndrome with Melatonin. Sleep. 1;28(10): 1271-1278. - PubMed

* Benloucif S, Orbeta L, Ortiz R, Janssen I, Finkel SI, Bleiberg J, Zee PC. (2004) Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults. Sleep. 27(8):1542-51. - PubMed

* Reid KJ, Chang A, Dubocovich, ML, Turek FW, Takahashi JS, Zee PC. (2001) Familial Advanced Sleep Phase Syndrome. Arch Neurol. 58: 1089-1094. - PubMed

* Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, Turek FW. (2000) The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse. J Neurosci. 1;20(21): 8138-43. - PubMed

* Naylor E, Penev PD, Orbeta L, Janssen I, Ortiz R, Colecchia EF, Keng M, Finkel S, Zee PC. (2000) Daily Social and Physical Activity Increases Slow-Wave Sleep and Daytime Neuropsychological Performance in the Elderly. Sleep. 1;23(1): 87-95. - PubMed

* Benloucif S, Bauer GL, Dubocovich ML, Finkel SI, Zee PC. (1999) Nimodipine Potentiates the Light-Induced Suppression of Melatonin. Neurosci Lett. 3;272(1): 67-71. - PubMed

* Naylor E, Buxton OM, Bergmann BM, Easton A, Zee PC, Turek FW. (1998) Effects of Aging on Sleep in the Golden Hamster. Sleep. 1;21(7): 687-93. - PubMed

* Labyak SE, Turek FW, Wallen EP, Zee PC. (1998) Effects of Bright Light on Age-Related Changes in the Locomotor Activity of Syrian Hamsters. Am J Physiol. 274(3 Pt 2): R830-9. - PubMed