Northwestern University Feinberg School of Medicine

Center for Circadian and Sleep Medicine

Clinical Trials

The Center for Circadian and Sleep Medicine is focused on clinical research. Learn more about the trials and participation opportunities via the search results for Northwestern Neurology on clinicaltrials.gov. Below is a selected list of our current active protocols.

Feinberg Clinical Trials

Scientists at the medical school are conducting hundreds of clinical trials daily. Learn more about all our work via the Feinberg Office of Research Clinical Trials page. Search for trials by disease or condition.

Asteria Survey

Please complete this survey if you are interested in participating in the Asteria clinical trial (details below).

Trials
Sleep Disturbance and Metabolic Syndrome
The goal of this study is to determine the ability of auditory stimulation with these sound waves to improve sleep, cardiovascular disease and metabolic function in patients with elevated cardiovascular disease risk factors. The study will involve a home …
The goal of this study is to determine the ability of auditory stimulation with these sound waves to improve sleep, cardiovascular disease and metabolic function in patients with elevated cardiovascular disease risk factors. The study will involve a home sleep test to look for sleep apnea and 7-days of at-home activity monitoring using a wristwatch before the inpatient visit. This study will also include surveys, blood draws, and overnight sleep studies. There is compensation for completing the study.
Need to be overweight, have high blood pressure (130/85 or higher), high blood sugar (110 or higher) in the past month, difficulty falling or staying asleep, and have daytime sleepiness and poor sleep quality. Total time commitment – 2 visits: One outpatient visit (2-3 hours) and one 5-day/4-night inpatient visit for overnight sleep studies at Northwestern Memorial Hospital.
Zee, Phyllis CZee, Phyllis C
STU00074507
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Ortiz, Rosemary J 1-888-NU-STUDY
Cardiometabolic outcomes with light exposure during sleep
The overall aim is to determine the impact of light during the sleep period on cardiometabolic outcomes and melatonin. We hypothesize that light at night contributes to circadian and sleep disruptions that may then lead to adverse cardiometabo…
The overall aim is to determine the impact of light during the sleep period on cardiometabolic outcomes and melatonin. We hypothesize that light at night contributes to circadian and sleep disruptions that may then lead to adverse cardiometabolic outcomes. Light pollution, and specifically light at night, has been shown to impact circadian rhythms via changes to melatonin, sleep, and other parameters. Poor sleep, changes in melatonin, and circadian disturbances are known to affect cardiometabolic outcomes. Therefore, it is plausible that light exposure during the sleep period may adversely impact next day cardiometabolic outcomes. Understanding the consequences of light during the sleep period is of great interest considering the high prevalence of light pollution in modern society.
If you are 18-40 years of age with a regular sleeping schedule. Please visit https://www.surveymonkey.com/s/LANstudy
Zee, Phyllis CZee, Phyllis C
STU00094737
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Cheung, Ivy N 1-888-NU-STUDY
Biochronicity Grand Challenge: Human Time Stamp Development, Validation and Prediction
This research is being done to develop a diagnostic test that will determine the time of your internal clock from a single blood draw. We want to determine whether changes to the internal clock, reflected in this …
This research is being done to develop a diagnostic test that will determine the time of your internal clock from a single blood draw. We want to determine whether changes to the internal clock, reflected in this blood test, can predict recovery from traumatic brain injury.
Between the ages of 18-55 and have had a traumatic brain injury.
Zee, Phyllis CZee, Phyllis C
STU00200445
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Gendy, Maged 1-888-NU-STUDY
Circadian rhythms and epilepsy: a prospective study
This study is to further understand the link between epilepsy, sleep and circadian rhythms. We propose to characterize sleep-wake and circadian rhythm patterns in patients with epilepsy (PWE). To assess the interactions between circadian function an…
This study is to further understand the link between epilepsy, sleep and circadian rhythms. We propose to characterize sleep-wake and circadian rhythm patterns in patients with epilepsy (PWE). To assess the interactions between circadian function and sleep quality with seizure frequency and timing by data from self- reported sleep and circadian chronotype questionnaires, sleep diaries, seizure type and frequency as reported by the subjects’ primary physician, and objective sleep (actigraphy) and circadian rhythm measures.
Adults (18 years of age and older) with generalized seizures and focal seizures.
Patients are allowed to remain on their usual regimen of antiepileptic medications.

Zee, Phyllis CZee, Phyllis C
STU00201284
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Erlikh, Natanie 1-888-NU-STUDY
Modeling Neuroscience for Enhancing Memory Operations through Non-Invasive Channels (MNEMONIC)
Slow wave sleep, or deep sleep, is important for memory consolidation. Enhancing slow wave or deep sleep may be beneficial for memory performance. We have recently developed a new approach to increase slow …
Slow wave sleep, or deep sleep, is important for memory consolidation. Enhancing slow wave or deep sleep may be beneficial for memory performance. We have recently developed a new approach to increase slow wave sleep by delivering sound waves played through headphones in a specific sequence. When applied during sleep the sound waves increase the total amount and amplitude of deep slow wave sleep. The goal of this study is to determine the ability of these sound waves to improve sleep and memory. We are looking for people who healthy. This study would involve a total of 5 visits (2 inpatient visits and 3 outpatient visits). The first visit is a detailed screening visit which involves informed consent, medical history, physical examination, and surveys. That visit takes place at the Circadian Rhythms and Sleep Research Laboratory in Abbott Hall, located in the Northwestern University Chicago Campus. You will also be given an activity monitor that senses movement and is worn like a watch for 1 week and a home sleep test to look for sleep apnea to wear for 1 night. You will be asked to return the devices either in person or a pre-paid envelope. The second and fourth visit is a 3-day/2-night stay at Northwestern Memorial Hospital and involves sleep studies each night. You will also be given some surveys and brief attention testing. There will be blood draws 2 times each day stay starting after the first night and a few blood draws overnight. You will be randomized (like a coin flip) to one of two groups: the sound wave stimulation or a sham-stimulation (like a placebo). You will not be allowed to know which group you are in. On the 2nd night of each visit, this stimulation or sham stimulation will be applied. Following each inpatient visit your will return 48 hours later to complete 1 hour of memory tasks. For your participation, you will get up to $900 in compensation. If you have questions about the study, you may ask now. You will also get more details and have more time to ask questions at the first study visit if you are interested and are eligible for this study.
18-35 years old
Zee, Phyllis CZee, Phyllis C
STU00202059
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Gendy, Maged 312 503 2519
Multidisciplinary Treatment for Obstructive Sleep Apnea and Insomnia
The MATRICS Study - This study aims to investigate the effectiveness of different combinations and sequences of evidence-based treatment strategies for people with both Obstructive Sleep Apnea and Insomnia. Participants will be rand…
The MATRICS Study - This study aims to investigate the effectiveness of different combinations and sequences of evidence-based treatment strategies for people with both Obstructive Sleep Apnea and Insomnia. Participants will be randomly assigned to one of three treatment conditions using a medical device known as CPAP, or using this device in combination with a behavioral treatment to improve sleep.
Inclusion Criteria:
Males and Females age 18 and older;
Meets criteria for Obstructive Sleep Apnea;
Meets criteria for an Insomnia Disorder; Able to make around 15 in-person visits over 7-9 months.
Exclusion Criteria:
Comorbid medical condition that requires immediate treatment of OSA;
Severe cases of OSA that require immediate treatment;
Psychiatric conditions that may interfere with study protocol or uncontrolled psychiatric conditions that require immediate treatment;
Comorbid sleep disorders that require treatment outside of the study protocol;
Other sleep-related breathing disorder besides OSA;
Excessive daytime sleepiness that requires immediate treatment or presents significant risk;
CPAP use or formal CBT for insomnia within the past 6 months.
Ong, Jason COng, Jason C
NCT01785303 STU00203478
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Yap, Bonnie 312 503 6627
Evaluating the Circadian Response to Light in Delayed Sleep-Wake Phase Disorder
This study is looking at factors that contribute to the timing of sleep. Interested subjects will undergo screening to determine their sleep-wake habits, then will have an eye test and a blood draw. Participation will i…
This study is looking at factors that contribute to the timing of sleep. Interested subjects will undergo screening to determine their sleep-wake habits, then will have an eye test and a blood draw. Participation will involve 2 outpatient visits, separated by up to 3 weeks of sleep-wake activity monitoring.
Individuals with delayed sleep-wake phase disorder and healthy controls
Abbott, SabraAbbott, Sabra
  • Map it 201 E. Huron St.
    Chicago, IL
STU00203647
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Abbott, Sabra 312 503 3561
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Parallel-Group Study of the Efficacy and Safety of Lemborexant in subjects 55 Years and Older with Insomnia Disorder
This study is being done by Eisai Inc., a company that does drug research studies in order to develop ne…
This study is being done by Eisai Inc., a company that does drug research studies in order to develop new drugs. Eisai is studying a drug called lemborexant or E2006, being developed to treat people with insomnia disorder. The main goal of this study is to compare the effectiveness of two strengths of lemborexant with another drug called zolpidem tartrate extended release tablets (zolpidem ER), (also known as Ambien® Controlled Release tablets) and placebo. Everyone in the study will get placebo at some time during the study. The placebo is a tablet that looks like lemborexant or zolpidem ER but has no active drug in it. The study will last about 10 weeks and involves 9 visits of which 7 of those visits will be overnight sleep studies follow with daytime testing.
Female age 55 years old or male age 65 or older. Trouble falling asleep and/or staying asleep.
Abbott, SabraAbbott, Sabra
  • Map it 675 N. St. Clair St. Suite 20-100
    Chicago, IL
NCT02783729 STU00203381
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Ortiz, Rosemary J 312 908 1024
Asteria
If you are between 19-40 years old, you may be eligible for a research study at Northwestern University. Researchers are investigating the effects of sleep on performance. Study Requirements: • Ages 19 – 40 Total time commitment – 4 visits: • 1 outpatient visit (1-2 hours) • …
If you are between 19-40 years old, you may be eligible for a research study at Northwestern University. Researchers are investigating the effects of sleep on performance. Study Requirements: • Ages 19 – 40 Total time commitment – 4 visits: • 1 outpatient visit (1-2 hours) • 3 separate 24-hour inpatient visits at our downtown location For screening purposes the study will involve 7-days of at-home activity monitoring using a wristwatch. If eligible the same device will be worn throughout the study. The study will also include surveys, cognitive testing, and overnight sleep studies. Each inpatient visit will last approximately 24 hours. The study is being conducted by faculty in the Northwestern University Feinberg School of Medicine. If interested please complete the following survey: https://redcap.nubic.northwestern.edu/redcap/surveys/?s=YXNC3YNE9N
Zee, Phyllis CZee, Phyllis C
STU00204417
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Urban, Claudia 312 503 3781
Home sleep and circadian phase: mediators of racial disparities in diabetes risk
Screening includes overnight stay with a full sleep study and morning blood tests. If you qualify full study includes 1 week of wrist actigraphy at home, saliva collectioning at home for one evening, home visit by study …
Screening includes overnight stay with a full sleep study and morning blood tests. If you qualify full study includes 1 week of wrist actigraphy at home, saliva collectioning at home for one evening, home visit by study staff, and second overnight stay with blood tests the next morning.
Age 21-50. African American or Caucasian. Healthy adult.
Knutson, KristenKnutson, Kristen
  • Map it 201 E. Huron St.
    Chicago, IL
NCT01786564 STU00204605
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Brenner-Jedwabnik, Matthew 312 503 4965
Morning Light Treatment at Home to Improve Glucose Metabolism in People at Increased Risk for Type 2 Diabetes
The study is titled “Morning Light Treatment.” We think there may be a relationship between sleep and diabetes, and morning light treatment delivered through a head worn light device coul…
The study is titled “Morning Light Treatment.” We think there may be a relationship between sleep and diabetes, and morning light treatment delivered through a head worn light device could improve glucose metabolism in people with prediabetes.
We are looking for people ages 40-65, who are overweight or obese, do not currently have diabetes, and are in good health. The study involves screening blood tests, at-home apnea test, 5 weeks of wrist actigraphy, a 4 week period where you would wear a light device for one hour in the morning, and 2 overnight laboratory sessions that include saliva, urine, and blood samples. You will be compensated up to $525, $50 for the screening and $95 for each week of participation.
Knutson, KristenKnutson, Kristen
  • Map it 201 E. Huron St.
    Chicago, IL
STU00204710
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Brenner-Jedwabnik, Matthew 312 503 4965