Focus of Work
Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.
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Alzheimer's DiseaseBiochemistry: ProteinsCell BiologyMolecular GeneticsMolecular BiologyNeuroscienceAgingAlzheimer's Drug
Education and Certification
- PhD: University of Chicago, Molecular Genetics (1992)
- Postdoctoral Fellowship: Columbia University, Molecular Neuroscience (1996)
Tarry Building Room 7-735
300 E Superior
Chicago IL 60611