Northwestern University Feinberg School of Medicine
Faculty Profiles
Craig M Horbinski, MD, PhD

Craig M Horbinski, MD, PhD

Associate Professor of Pathology/Neurological Surgery

Focus of Work

Bio

The main focus of our laboratory is developing a better understanding of how key mutations in gliomas alter their biological characteristics, and how best to exploit specific weaknesses that such mutations often impart. In particular, our laboratory focuses on mutant isocitrate dehydrogenase 1 (mutIDH1), which is present in the vast majority of WHO grade II and III gliomas. This mutation has profound effects on the epigenome and metabolome, yet produces tumors that are markedly less aggressive. ...[Read full text]The main focus of our laboratory is developing a better understanding of how key mutations in gliomas alter their biological characteristics, and how best to exploit specific weaknesses that such mutations often impart. In particular, our laboratory focuses on mutant isocitrate dehydrogenase 1 (mutIDH1), which is present in the vast majority of WHO grade II and III gliomas. This mutation has profound effects on the epigenome and metabolome, yet produces tumors that are markedly less aggressive. Our work indicates that mutIDH1 also dramatically alters the glioma’s micro-environmental landscape by preventing the thrombosis-necrosis phenomenon that is characteristic of IDH1 wild-type gliomas. Furthermore, mutIDH1 increases the risk of seizures in patients. We are currently exploring the mechanisms by which these phenomena occur, as it will have major implications for understanding why mutIDH1 gliomas are less aggressive and how to better manage both wtIDH1 and mutIDH1 gliomas.

On a clinical level, I specialize in the use of molecular testing in brain tumors to improve our diagnostic and prognostic accuracy. This is helping us achieve the goal of personalized medicine through cutting-edge next generation sequencing.[Shorten text]

Keywords


Education and Certification

  • PhD: State University of New York, Pharmacology (2003)
  • MD: State University of New York (2003)
  • Postdoctoral Fellowship: University of Pittsburgh, Neuropathology (2004)
  • Residency: University of Pittsburgh, Anatomic Pathology (2007)
  • Fellowship: University of Pittsburgh, Neuropathology (2009)

Contact

312-503-6127
Laboratory: 312-503-4209

Tarry 2-705
300 East Superior Street
Chicago IL 60611