Focus of Work
The other major direction of our research is in the bone toxicology arena, where we aim to elucidate the molecular mechanisms by which pervasive environmental toxicants--such as those present in cigarette smoke--inhibit osteoblastic differentiation and bone healing. We have a particular interest in ligand activators of the Aryl Hydrocarbon Receptor (Ahr), such as dioxin (TCDD), which is a potent carcinogen. We have found that dioxin inhibits bone regeneration and spine fusion in a rat pre-clinical model. Therefore, current work is focused on the identification of downstream targets of dioxin action in osteoblast progenitor cells, as well as the evaluation of the capacity for Ahr antagonists to protect against dioxin-induced pseudarthrosis. The long-term goal of this work is to identify a viable therapeutic approach to combat the inhibitory effects of smoking on bone healing.[Shorten text]
Education and Certification
- PhD: University of California-Los Angeles (2007)
Robert H Lurie Medical Research Center Room 11-221
303 E Superior
Chicago IL 60611
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