Northwestern University Feinberg School of Medicine
Faculty Profiles
Joon W Yoon, PhD

Joon W Yoon, PhD

Research Assistant Professor of Pediatrics (Developmental Biology)

Focus of Work

Bio

I have been studying GLI family oncogenes and other genes closely associated with GLI1. GLI1, a mediator of Sonic hedgehog signal, was first identified as an amplified gene in malignant gliomas. Subsequently, GLI1 amplification and or abnormal activation were observed a wide variety of cancers (approximately 30% of solid tumors). However, the role of GLI1 in the development of human cancers still remains unclear. I have been interested in understanding the mechanism of action of GLI1 and its...[Read full text]I have been studying GLI family oncogenes and other genes closely associated with GLI1. GLI1, a mediator of Sonic hedgehog signal, was first identified as an amplified gene in malignant gliomas. Subsequently, GLI1 amplification and or abnormal activation were observed a wide variety of cancers (approximately 30% of solid tumors). However, the role of GLI1 in the development of human cancers still remains unclear. I have been interested in understanding the mechanism of action of GLI1 and its role for transformation by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some cancers that are resistant to chemotherapy. I am also interested in the role of SMO and/or GLI1 inhibitors in synergistic alleviation of drug-resistance in combination with conventional chemotherapy drugs. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Texas, Developmental Biology (1993)

Contact

Administrative office: 773-755-6516

Stanley Manne Children’s Research Institute Box MC204
225 East Chicago Avenue
Chicago IL 60611