Northwestern University Feinberg School of Medicine
Faculty Profiles
Joon W Yoon, PhD

Joon W Yoon, PhD

Research Assistant Professor of Pediatrics (Developmental Biology)

Focus of Work

Bio

I have been studying role for GLI family oncogenes and associated genes in cancers. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers still remains unclear.

Academic Focus

I have been studying the mechanism of action of GLI1 and its role for cellular transformation and oncogenesis by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I am using Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors....[Read full text]I have been studying the mechanism of action of GLI1 and its role for cellular transformation and oncogenesis by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I am using Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Texas, Developmental Biology (1993)

Contact

Laboratory: 773-755-6516

2430 N. Halsted
Chicago IL 60614