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Northwestern University Feinberg School of Medicine
Nervous System Tumor Bank

Publications

The brain and spinal cord donation program supports research efforts to understand more about the devastating disease of glioma. Below are links to publications which utilized research donations from our program.

  1. Tripathi S, Najem H, Hurley L, Du R, Dmello C, Ali H, McCortney K, Habashy KJ, Zhang P, Horbinski CM  et al.  STING-induced blood-brain barrier opening combined with radiotherapy potentiates antitumor response in a high-grade glioma model.  J Clin Invest  2026 Feb 16;136(4). pii:e198843
  2. Padilla F, Arvanitis C, Bollard CM, Gallus M, De Groot J, Klein RS, Ransohoff RM, Sonabend AM, Okada H  Focused ultrasound-enhanced cell therapy for brain tumors: Summary of roundtable discussions.  Neurooncol Adv  2026;8(1):vdag026. pii:vdag026
  3. Abi Faraj C, McCutcheon IE, Strickland BA, Debnam JM, Suki D, Lin HY, Ahmed S, O'Brien BJ, Gubbiotti MA, Mayer RR  et al.  Ventricular entry and postoperative leptomeningeal metastasis after resection of supratentorial high-grade glioma.  J Neurosurg  2026 Feb 13;:1-15. doi:10.3171/2025.9.JNS25526
  4. Youngblood MW, Tripathi S, Najem H, Congivaram H, Gomez M, Sears TK, Hurley L, Billingham LK, Silvers C, Wang W  et al.  STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.  Nat Commun  2026 Feb 12;. doi:10.1038/s41467-026-69296-1
  5. Texakalidis P, Wolinsky JP, Gettman MT, Spinner RJ  Whose Hands on the Robot? Rethinking Roles in Nerve Sheath Tumor Surgery.  World Neurosurg  2026 Feb 11;207:124796. doi:10.1016/j.wneu.2026.124796
  6. Mirian C, Jensen LR, Hoffmann AG, Juratli TA, Maier AD, Lindner P, Broechner A, Torp SH, Shih HA, Morshed RA  et al.  Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.  J Neurooncol  2026 Feb 09;176(3):201. pii:201
  7. Castellino RC, Mumme H, Franson A, Yu B, Robinson H, Dhodapkar K, Aguilera D, Schniederjan M, Keesari R, He Z  et al.  First-in-child phase I trial of p-STAT3 inhibitor WP1066 in pediatric brain tumor patients.  JCI Insight  2026 Feb 09;11(3). pii:e194823
  8. Lukas RV, Du R, Congivaram H, McCortney K, Dixit K, Horbinski C, Schwartz M, Lezon R, Singer L, Primdahl D  et al.  Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma.  JCI Insight  2026 Feb 03;. pii:e198475
  9. Lalchungnunga H, Dampier CH, Singh O, Hoang DT, Shulman ED, Abdullaev Z, Li B, Luo Z, Wu Z, Pearce TM  et al.  Classification accuracy of a hierarchical molecular inference-based deep-learning system for CNS tumour diagnosis: a multi-institutional, retrospective study.  Lancet Oncol  2026 Feb;27(2):243-253. doi:10.1016/S1470-2045(25)00661-8
  10. Budhiraja S, Faisal UH, Baisiwala S, Chojak R, Koutah L, Drewes NB, Cho S, Kazi HA, Chen R, Perrault EN  et al.  THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression.  Neoplasia  2026 Feb;72:101271. pii:101271
  11. Goerzen D, Kim M, Schroff C, Hoang MN, Wollowitz JS, Kolb A, Walshon JP, McCortney K, Horbinski C, Galbraith K  et al.  Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature.  Nat Nanotechnol  2026 Feb;21(2):277-287. doi:10.1038/s41565-025-02080-2
  12. Dixit KS, Kumthekar P, Lukas RV, Williams A, Tate MC, Chandler JP, Jamshidi P, Helenowski I, Zhang H, Bloch O  et al.  A phase 2, open label, clinical trial of pre-surgical and adjuvant treatment of recurrent glioblastoma with tremelimumab and durvalumab alone and in combination.  J Neurooncol  2026 Jan 28;176(3):185. doi:10.1007/s11060-026-05446-1
  13. Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P  Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.  Cancer Res  2026 Jan 02;86(1):12-21. doi:10.1158/0008-5472.CAN-25-1791
  14. Whipple-Bones S, Tabor MH, Magill ST, Terrell D, Beer-Furlan A  Combined transcranial and endoscopic endonasal approach for anterior skull base meningiomas: approach and reconstruction strategies.  Neurosurg Focus Video  2026 Jan;14(1):V19. pii:V19
  15. Trautmann RK, Dennison N, McCortney K, Klier S, Cosacak MI, Werner C, Akyoldas G, Horbinski CM, Freudenberg U, Kizil C  High-Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening.  Macromol Biosci  2026 Jan;26(1):e00394. pii:e00394
  16. Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS  et al.  YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.  Neuro Oncol  2026 Jan 01;28(1):159-174. doi:10.1093/neuonc/noaf227
  17. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinkski CM, Chandler JP, Heimberger AB  et al.  Meningioma cell reprogramming and microenvironment interactions underlie brain invasion.  Neuro Oncol  2025 Dec 31;. pii:noaf292
  18. Duckett D, Santana-Santos L, McCord M, Smith V, Lopes MBS, Youngblood MW, Magill ST, Chandler JP, Heimberger AB, Lukas R  et al.  Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas.  Acta Neuropathol Commun  2025 Dec 29;13(1):259. pii:259
  19. Amirkhani N, Maroufi F, Pour-Rashidi A, Shirani M, Chandler JP  Impact of anti-seizure medication duration on postoperative seizures following supratentorial high-grade glioma resection: a mixed-model and tree-based approach.  J Neurooncol  2025 Dec 23;176(2):134. doi:10.1007/s11060-025-05373-7
  20. Miyashita Y, Kaiho T, Nagata H, Hiroshima T, Sugiura Y, Zhang K, Kelly ME, Yan Y, Toyoda T, Steffens A  et al.  Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction.  Eur Respir J  2025 Dec 18;. pii:2501738
  21. Aucoin L, Templer JW, Tate MC, Dixit KS  The role of a multidisciplinary clinic for management of patients with IDH mutant gliomas.  Front Oncol  2025;15:1729589. pii:1729589
  22. Youngblood MW, Kumari A, Kang YT, Gould A, Habashy K, Gomez M, Lingamarla H, Morey T, Chen L, Congivaram H  et al.  Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.  Nat Commun  2025 Dec 16;16(1):11045. pii:11045
  23. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
  24. Haddad AF, Ramesh R, Zakimi N, Chen JS, Quintana D, Gil E, Kabir AS, Sibih YE, Lugo BM, Bhalla S  et al.  Preoperative embolization improves local control and modulates gene expression in atypical WHO grade 2 meningioma.  Neuro Oncol  2025 Dec 01;27(12):3176-3188. doi:10.1093/neuonc/noaf203
  25. Limbrick DD, Skoch J, Auguste K, Grant GA, Lam SK, Tate MC, Langer DJ, Roland JL, Alden TD, Charbel FT  et al.  A Multicenter Study of Noninvasive Wireless Assessment of Cerebrospinal Fluid Shunt Function in Hydrocephalus Patients.  Neurosurgery  2025 Dec 01;97(6):1397-1405. doi:10.1227/neu.0000000000003569
  26. Fanuzzi M, Zheng S, Horbinski CM, Shaaban MA, Congivaram H, Du R, Tripathi S, Hurley L, Kumthekar P, Ahmed A  et al.  Targeting Survivin: Now I Become Death, the Destroyer of Cells.  Int J Mol Sci  2025 Nov 26;26(23). pii:11417
  27. Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM  Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high-grade IDH mutant gliomas.  JCI Insight  2025 Nov 24;10(22). pii:e195385
  28. Sadagopan NS, Chaliparambil RK, Du R, Sriram N, Jain R, Benato A, Prasad D, Cach G, Alghoul MS, Ellis MF  et al.  Effect of early mobilization on 30-day wound complications following sacral amputation for en bloc tumor resection.  J Neurosurg Spine  2025 Nov 14;44(2):293-299. doi:10.3171/2025.7.SPINE25488
  29. Mahajan AS, Dussold C, Kim S, Jarvis R, Hurley LA, Tommasini-Ghelfi S, Park J, Forsyth CM, Zhang B, Miska J  et al.  cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.  Proc Natl Acad Sci U S A  2025 Nov 11;122(45):e2409557122. pii:e2409557122
  30. Khazanchi R, Govind S, Congivaram HT, Sadagopan NS, Jain R, Magill ST  Assessment of "Zero-Shot" General Purpose Segmentation Models: An Analysis of the Meta "Segment Anything Model" on Meningioma MRI.  AJNR Am J Neuroradiol  2025 Nov 03;46(11):2310-2315. doi:10.3174/ajnr.A8816
  31. Khalili BF, Chojnacki MR, Dixit K, Gururangan K, Horbinski C, Rosenow JM, Hsieh JK, Magill ST, Tate MC, Lukas RV  et al.  Surgical Treatment of Brain Tumor-Related Epilepsy: Current and Emerging Strategies.  Cancers (Basel)  2025 Nov 01;17(21). pii:3539
  32. Iorga M, Schneider N, Cho J, Tate MC, Parrish TB  A heat flow approach to functional infrared thermography.  J Neurosci Methods  2025 Nov;423:110560. doi:10.1016/j.jneumeth.2025.110560
  33. Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG  et al.  The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients.  J Neurooncol  2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
  34. Zannikou M, Duffy JT, Procissi D, Najem H, Levine RN, Thakur A, Hambardzumyan D, Lee-Chang C, Leoni L, Horbinski CM  et al.  Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models.  J Immunother Cancer  2025 Oct 28;13(10). pii:e011714
  35. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.  Neuro Oncol  2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
  36. Hung CY, Kang EY, Jacek K, Yu C, Zhang X, Zhu Y, Aftabizadeh M, Wong RA, Badie B, Świderski P  et al.  Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade.  Neuro Oncol  2025 Oct 14;27(9):2296-2312. doi:10.1093/neuonc/noaf099
  37. Sadagopan NS, Jain R, Chaliparambil RK, Khazanchi R, Rosenow JM, Potts MB, Chandler JP, Tate MC, Magill ST, Geynisman-Tan J  Sex Disparities in Normal Pressure Hydrocephalus Diagnosis and Urinary Outcomes.  Urogynecology (Phila)  2025 Oct 01;. doi:10.1097/SPV.0000000000001737
  38. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Oct 01;43(4):481-488. doi:10.3171/2025.3.SPINE241408
  39. Nandoliya KR, Sadagopan NS, Karras CL, Cohen LM, Magill ST  Exoscopic Repair of Orbital Meningoencephalocele Causing Pulsatile Proptosis: A 2-Dimensional Operative Video.  Oper Neurosurg  2025 Oct 01;29(4):600-601. doi:10.1227/ons.0000000000001470
  40. Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P  et al.  Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205.  Res Sq  2025 Sep 25;. pii:rs.3.rs-7567487
  41. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: Mechanisms and therapeutic avenues.  Neuro Oncol  2025 Sep 17;27(8):1932-1945. doi:10.1093/neuonc/noaf063
  42. Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S  et al.  The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas.  Oper Neurosurg  2025 Sep 16;. doi:10.1227/ons.0000000000001762
  43. Arrieta VA, Benotmane JK, Du R, Habashy KJ, Zhao J, Najem H, Wang S, Hou D, Katz JL, Vázquez-Cervantes GI  et al.  Integrated immune profiling of chordomas reveals spatially organized niches and functional heterogeneity.  Neuro Oncol  2025 Sep 11;. pii:noaf213
  44. Castellani RJ, Najem H, Heimberger AB, Jamshidi P  Myeloid-mediated cerebral amyloid vasculitis and the potential role of the immune response in brain atrophy.  J Clin Invest  2025 Sep 02;135(17). pii:e195137
  45. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  46. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H  et al.  Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.  Nat Med  2025 Sep;31(9):3204. doi:10.1038/s41591-025-03895-1
  47. Sadagopan NS, Khazanchi R, Houskamp EJ, Nandoliya KR, Chaliparambil RK, Govind S, Alwakeal A, Zhang H, Cannone D, Grivas J  et al.  Extended lumbar drain trials for diagnostic evaluation of idiopathic normal pressure hydrocephalus with the Berg Balance Scale.  J Neurosurg  2025 Sep 01;143(3):863-870. doi:10.3171/2025.1.JNS242354
  48. Houskamp EJ, Skorich EL, Mackie MA, Tate MC  Impact of High-Grade Glioma Lesion Location on Preoperative Neuropsychological Deficits.  Cancers (Basel)  2025 Aug 26;17(17). pii:2775
  49. Sykora DJ, Sridhar S, Modica JA, Yeeravalli R, Salaria RK, Gu Z, Lesniak MS, Mrksich M  The Role of MegaMolecule Antibody Structure in Internalization and Signaling.  ACS Chem Biol  2025 Aug 15;20(8):2014-2027. doi:10.1021/acschembio.5c00421
  50. Benato A, Texakalidis P, Wolinsky JP  Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor.  Eur Spine J  2025 Aug 14;. doi:10.1007/s00586-025-09141-z