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Our Department

We investigate mechanisms of bacterial and viral pathogenesis as well as regulation of the immune system. Our faculty members teach graduate, undergraduate and medical students at Northwestern University and the Feinberg School of Medicine. Learn more about us.

Recent Publications

• Adenovirus E1A Oncogene Induces Re-replication of Cellular DNA and Alters DNA Replication Dynamics.

  Singhal G, Leo E, Gadham Setty SK, Pommier Y, Thimmapaya B.

  J Virol. 2013 Jun 5. [Epub ahead of print]

• Roles of MicroRNAs in the Life Cycles of Mammalian Viruses.

  Gottwein E.

  Curr Top Microbiol Immunol. 2013;371:201-27. doi: 10.1007/978-3-642-37765-5_8.

• B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.

  Podojil JR, Liu LN, Marshall SA, Chiang MY, Goings GE, Chen L, Langermann S, Miller SD.

  J Autoimmun. 2013 May 14. doi:pii: S0896-8411(13)00048-6. 10.1016/j.jaut.2013.04.001. [Epub ahead of print]

• The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.

  Hong S, Laimins LA.

  PLoS Pathog. 2013 Apr;9(4):e1003295. doi: 10.1371/journal.ppat.1003295. Epub 2013 Apr 4.

• Analysis of Vibrio cholerae genome sequences reveals unique rtxA variants in environmental strains and an rtxA-null mutation in recent altered El Tor isolates.

  Dolores J, Satchell KJ.

  MBio. 2013 Apr 16;4(2):e00624. doi: 10.1128/mBio.00624-12.

• Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture.

  Bohannon KP, Jun Y, Gross SP, Smith GA.

  Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1613-20. doi: 10.1073/pnas.1221896110. Epub 2013 Apr 8.

• The functions of type I and type II natural killer T cells in inflammatory bowel diseases.

  Liao CM, Zimmer MI, Wang CR.

  Inflamm Bowel Dis. 2013 May;19(6):1330-8. doi: 10.1097/MIB.0b013e318280b1e3.

• High-mobility group box 1 protein (HMGB1) neutralization ameliorates experimental autoimmune encephalomyelitis.

  Robinson AP, Caldis MW, Harp CT, Goings GE, Miller SD.

  J Autoimmun. 2013 Jun;43:32-43. doi: 10.1016/j.jaut.2013.02.005. Epub 2013 Mar 17.

• Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow.

  Nabors LK, Wang LD, Wagers AJ, Kansas GS.

  Exp Hematol. 2013 Mar 14. doi:pii: S0301-472X(13)00067-2. 10.1016/j.exphem.2013.02.014. [Epub ahead of print]

• The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae.

  Gunderson FF, Cianciotto NP.

  MBio. 2013 Mar 12;4(2):e00074-13. doi: 10.1128/mBio.00074-13.