News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Department of Biochemistry and Molecular Genetics. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards and honors.
Northwestern Medicine scientists have discovered an epigenetic imbalance that can lead to cancer, and used these findings to inhibit tumors in models.
Scientists are one step closer to a stem cell treatment for muscular dystrophy after Northwestern Medicine investigators demonstrated improvements in muscle tissue differentiation in stem cells.
Northwestern Medicine scientists have uncovered new findings about a protein called SET1B, which could offer a novel approach to treating triple-negative breast cancer.
Northwestern Medicine scientists have discovered that a protein called BRWD2/PHIP binds to H3K4 methylation, a key molecular event that influences gene expression.
A newly discovered gene mutation may increase a patient’s risk of genetic heart disease, presenting a target for therapy or genetic screening down the road.
Two Northwestern Medicine scientists have received NIH Director’s Awards, which fund innovative research with high-impact potential.
Northwestern Medicine scientists have discovered surprising findings about an enzyme central to gene expression and mutated in many cancers.
A Northwestern Medicine study found a novel chemical transformation in the formation of colibactin, a toxic agent produced by gut bacteria, including certain strains of E. Coli.
A new Northwestern Medicine study reveals surprising findings about an enzyme called Set1A and its function in embryonic stem cell self-renewal and differentiation.
The major features of Parkinson’s disease have been linked to a toxic cascade beginning with oxidized dopamine, providing a possible therapeutic pathway.
Northwestern scientists have found that nutritional, microbial and psychosocial exposures early in infant development predict DNA methylation later in life.
A synthetic material developed at Northwestern Medicine could direct a patient’s existing cells to transform into stem cells, creating a new treatment path for stem cell therapy.
The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.
A new Northwestern Medicine study, published in Genes and Development, has identified two DNA elements crucial to the activation of a set of genes that drive the early development of embryos.
Northwestern Medicine scientists have demonstrated an important role for the methylation of the amino terminus of a specific protein in maintaining centromere function and chromosome segregation, both important in cell division.
Northwestern Medicine scientists and collaborators have shown that a protein thought to form calcium ion channels instead regulates the activity of another member of the family to modulate immune responses.
A paper published in Molecular Cell provides new insight into a protein complex called COMPASS and its function during histone methylation, a key modification that regulates gene expression.
Northwestern Medicine scientists have identified a molecular therapy to prevent the growth of a rare pediatric leukemia.
Northwestern Medicine scientists have identified one of the molecular mechanisms behind the variability of holoprosencephaly, a congenital brain malformation.
Northwestern Medicine scientists have developed a new way to image chromatin within living cells, opening the door to large-scale screening techniques, including for cancer.
Northwestern Medicine scientists identified an enzyme as a potential new target for triple-negative breast cancer, a form of breast cancer that is associated with early tumor recurrence and significantly increased mortality rates.
Northwestern’s biomaterials labs are developing the next generation of materials in medicine, called supramolecular biomaterials – molecules designed in a way to mimic cell structures and functions of biological signaling.
When it comes to gene regulation, there are more similarities between fruit flies and humans than previously thought, according to new Northwestern Medicine research.
Ali Shilatifard, PhD, has been named the 15th recipient of the Martin E. and Gertrude G. Walder Award for Research Excellence, an honor given annually by the provost that recognizes excellence in research at Northwestern University.
Northwestern Medicine scientists explore research that has shown how the balanced activities of two protein families regulate gene expression during embryonic development and how mutations that tip this balance lead to cancer.
The results of a recent study co-authored by C. David James, PhD, uncovered potential new targets for treating glioblastoma, a fatal brain tumor for which there is currently no cure.
Research led by Northwestern Medicine scientist Daniel Foltz, ’01 PhD, sheds light on the assembly of centromeres, a region of the chromosome that helps ensure new cells have 46 chromosomes.
A transcription factor protein may play an important role regulating genomic imprinting, a phenomenon where one of the two gene copies inherited from parents is silenced.
- Choi and colleagues define genetic landscapes of Lymphocytic Variant Hypereosinophilic Syndrome and Merkel Cell Carcinoma.01.21.2016
In a manuscript published in Blood, Choi and colleagues reported the first genetic mutation that underlies lymphocytic variant hypereosinophilic syndrome, an intractable immunological disease. This finding implicates the JAK-STAT pathway in this disease and suggests the potential utility of JAK-STAT inhibitors for the treatment of this disease.
In a paper published in Oncotarget, Choi and colleagues described the genetic landscape of Merkel Cell Carcinoma, a rare but deadly skin cancer. They describe the significant differences between virally associated and non-virally associated cancers as well as define the implications for immunotherapy. These findings are the foundation for using immunotherapy for virus-negative MCC’s, which is currently under study.