Research (RIKEN)

• 2003    Researcher, Pharmacia/Pfizer
• 2003    Research Assistant Professor, Department of Anesthesiology, Northwestern University Medical School

Memberships

• Society for Neuroscience
• Japanese Society of Applied Entomology and Zoology
• Pesticide Science Society of Japan

Publications

 Peer reviewed Journals

1.       Nagata, K., T. Saito and T. Miyata, 1989

Studies on the Mode of Action of Fenvalerate Enantiomers .1. Internal Distribution and Penetration of Fenvalerate in the German-Cockroach, Blattella-Germanica

Japanese Journal of Applied Entomology and Zoology, 33(4): p. 180-186. (in Japanese)

2.      Nagata, K., T. Saito and T. Miyata, 1991

Studies on the Mode of Action of Fenvalerate Enantiomers .4. Neural Effects of Fenvalerate Enantiomers on the American Cockroach, Periplaneta Americana (L).

Applied Entomology and Zoology, 26(3): p. 365-370.

3.      Nagata, K., M. Minamiyama, T. Saito and T. Miyata, 1991

Studies on the Mode of Action of Fenvalerate Enantiomers .2. Cuticular Penetration, Internal Distribution, Penetration and Absorption into Nerve-Tissue and Metabolism of Fenvalerate Enantiomers in the American Cockroach, Periplaneta-Americana (L).

Applied Entomology and Zoology, 26(2): p. 157-166.

4.      Nagata, K., M. Minamiyama, T. Saito and T. Miyata, 1991

Studies on the Mode of Action of Fenvalerate Enantiomers .3. Cuticular Penetration and Metabolism of Fenvalerate Enantiomers in the German-Cockroach, Blattella-Germanica (L) (Orthoptera, Blattellidae)

Applied Entomology and Zoology, 26(1): p. 41-47.

5.      Nagata, K. and T. Narahashi, 1994

Dual action of the cyclodiene insecticide dieldrin on the gamma-aminobutyric acid receptor-chloride channel complex of rat dorsal root ganglion neurons.

Journal of Pharmacology & Experimental Therapeutics, 269(1): p. 164-171.

6.      Nagata, K., B.J. Hamilton, D.B. Carter and T. Narahashi, 1994

Selective effects of dieldrin on the GABAA receptor-channel subunits expressed in human embryonic kidney cells

Brain Research, 1994. 645(1-2): p. 19-26

7.      Nagata, K. and T. Miyata, 1994

Differences in Penetration and Absorption of Fenvalerate between Normal and Desheathed Ventral Nerve Cords in the German-Cockroach, Blattella-Germanica (L).

Journal of Pesticide Science, 1994. 19(3): p. 221-223.

8.            Nagata, K. and T. Miyata, 1994

Effects of Fenvalerate on the Central and Peripheral Nervous Systems of the American Cockroach, Periplaneta-Americana (L).

Journal of Pesticide Science, 1994. 19(2): p. 73-77.

9.      Sone, S., K. Nagata, S. Tsuboi and T. Shono, 1994

Toxic Symptoms and Neural Effect of a New Class of Insecticide, Imidacloprid, on the American Cockroach, Periplaneta-Americana (L)

Journal of Pesticide Science, 19(1): p. 69-72.

10.    Nagata, K. and T. Narahashi, 1995

Differential effects of hexachlorocyclohexane isomers on the GABA receptor-chloride channel complex in rat dorsal root ganglion neurons.

Brain Research, 704(1): p. 85-91.

11.    Nagata, K. and T. Narahashi, 1995

Multiple actions of dieldrin and lindane on the GABAA receptor-chloride channel complex of rat dorsal root ganglion neurons.

Pesticide Science,. 44(1-7).

12.     Nagata, K., C.S. Huang, B.J. Hamilton, D.B. Carter and T. Narahashi, 1996

Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line.

Brain Research, 738(1): p. 131-137.

13.    Nagata, K., G.L. Aistrup, C.S. Huang, W. Marszalec, J.H. Song, J.Z. Yeh and T. Narahashi, 1996

Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol.

Neuroscience Letters, 217(2-3): p. 189-193.

14.    Nagata, K., G.L. Aistrup, J.H. Song and T. Narahashi, 1996

Subconductance-state currents generated by imidacloprid at the nicotinic acetylcholine receptor in PC 12 cells.

Neuroreport, 7(5): p. 1025-1028.

15.    Song, J.H., K. Nagata, C.S. Huang, J.Z. Yeh and T. Narahashi, 1996

Differential block of two types of sodium channels by anticonvulsants.

Neuroreport, 7(18): p. 3031-3036.

16.    Song, J.H., K. Nagata, H. Tatebayashi and T. Narahashi, 1996

Interactions of tetramethrin, fenvalerate and DDT at the sodium channel in rat dorsal root ganglion neurons.

Brain Research, 708(1-2): p. 29-37.

17.    Huang, C.S., J.H. Song, K. Nagata, J.Z. Yeh and T. Narahashi, 1997

Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons.

Journal of Pharmacology & Experimental Therapeutics, 282(3): p. 1280-1290.

18.    Huang, C.S., J.H. Song, K. Nagata, D. Twombly, J.Z. Yeh and T. Narahashi, 1997

G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons.

Brain Research, 762(1-2): p. 235-239.

19.    Nagata, K., C.S. Huang, J.H. Song and T. Narahashi, 1997

Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels.

Brain Research, 769(2): p. 211-218.

20.     Nagata, K., C.S. Huang, J.H. Song and T. Narahashi, 1997

Lead modulation of the neuronal nicotinic acetylcholine receptor in PC12 cells.

Brain Research, 754(1-2): p. 21-27.

21.     Nagata, K., I. Y., T. Shono and T. Narahashi, 1997

Modulation of the neuronal nicotinic acetylcholine receptor channel by imidacloprid and cartap

Pesticide Biochemistry and Physiology, 59: p. 119-128.

22.    Song, J.H., C.S. Huang, K. Nagata, J.Z. Yeh and T. Narahashi, 1997

Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

Journal of Pharmacology & Experimental Therapeutics, 282(2): p. 707-714.

23.    Ikeda, T., K. Nagata, T. Shono and T. Narahashi, 1998

Dieldrin and picrotoxinin modulation of GABA(A) receptor single channels. Neuroreport, 9(14): p. 3189-3195.

24.    Nagata, K., J.H. Song, T. Shono and T. Narahashi, 1998

Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nitromethylene heterocycle imidacloprid.

Journal of Pharmacology & Experimental Therapeutics, 285(2): p. 731-738.

25.    Nagata, K., T. Ikeda, E. Aoyama and T. Shono, 1998

Cartap modulation of the nicotinic acetylcholine receptor-channel of clonal rat phaeochromocytoma (PC12) cells.

Journal of Pesticide Science, 23(1): p. 40-43.

26.    Nagata, K., T. Ikeda, H. Honda and T. Shono, 1998

Suppression of voltage-gated sodium currents by the dihydropyrazole insecticide, DPX-JW062 in rat dorsal root ganglion neurons.

Journal of Pesticide Science, 23(1): p. 62-64.

27.    Ikeda T, Nagata K, Honda H, Shono T, Narahashi T, 1998

Insecticidal activity of Sikimi extract and its modulation of the GABA(A) receptor channel.

Pesticide Science 52:337-342.

28.    Ikeda, T., Y. Ozoe, E. Okuyama, K. Nagata, H. Honda, T. Shono and T. Narahashi, 1999

Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons.

British Journal of Pharmacology, 127(7): p. 1567-1576.

29.    Kanemoto, E., E. Okumura, K. Nagata and Y. Ozoe, 1999

Interaction of anisatin with rat rat brain GABAA receptors: allosteric modulation by competitive antagonists

Biochemical Pharmacology 58, 617-621

30.    Nagata, K., E. Aoyama, T. Ikeda and T. Shono, 1999

Effects of nitenpyram on the neuronal nicotinic acetylcholine receptor-channel in rat phaeochromocytoma PC12 cells.

Journal of Pesticide Science, 24(2): p. 143-148.

31.    Nagata, K., T. Ikeda and T. Shono, 1999

         Voltage-dependent modulation of the neuronal nicotinic acetylcholine receptor-channel by cartap.

Pesticide Science, 55(4): p. 452-456.

32.     Nagata K, Aistrup GL, Honda H, Shono T, Narahashi T, 1999

Modulation of the nicotinic acetylcholine receptor by dioscorine in clonal rat phaeochlomocytoma (PC12) cells.

Pesticide Biochemistry and Physiology 64:157-165.

33.    Zhao, X., K. Nagata, W. Marszalec, J.Z. Yeh and T. Narahashi, 1999

Effects of the oxadiazine insecticide indoxacarb, DPX-MP062, on neuronal nicotinic acetylcholine receptors in mammalian neurons.

Neurotoxicology, 20(4): p. 561-570.

34.    Hamano, H., K. Nagata, N. Fukada, H. Shimotahira, X.L. Ju and Y. Ozoe, 2000

5-[3,3-dimethylbutoxycarbonyl]-4-pentynoic acid and its derivatives inhibit ionotropic  gammma-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site.

Bioorganic & Medical Chemstry, 8: p. 665-674.

35.    Ikeda, T., X. Zhao, K. Nagata, Y. Kono, T. Shono, J.Z. Yeh and T. Narahashi, 2001

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons.

Journal of Pharmacology & Experimental Therapeutics,. 296(3): p. 914-921.

36.    Sugawara, T., Y. Tsurubuchi, K.L. Agarwala, M. Ito, G. Fukuma, E. Mazaki-Miyazaki, H. Nagafuji, M. Noda, K. Imoto, K. Wada, A. Mitsudome, S. Kaneko, M. Montal, K. Nagata, S. Hirose and K. Yamakawa, 2001

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction.

Proceedings of the National Academy of Sciences of the United States of America, 98(11): p. 6384-6389.

37.   Sugiyama, S., Y. Tsurubuchi, A. Karasawa, K. Nagata, Y. Kono and T. Shono, 2001

Insecticidal activity and cuticular penetration of indoxacarb and its N-decarbomethoxylated metabolite in organophosphorus insecticide-resistant and -susceptible strains of the housefly, Musca domestica (L.).

Journal of Pesticide Science,. 26(2): p. 117-120.

38.    Tsurubuchi, Y., X. Zhao, K. Nagata, Y. Kono, K. Nishimura, J.Z. Yeh and T. Narahashi, 2001

Modulation of tetrodotoxin-resistant sodium channels by dihydropyrazole insecticide RH-3421 in rat dorsal root ganglion neurons.

Neurotoxicology, 22(6): p. 743-753.

39.    Tsurubuchi, Y., A. Karasawa, K. Nagata, T. Shono and Y. Kono, 2001

Insecticidal activity of oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite and their modulations of voltage-gated sodium channels.

Applied Entomology and Zoology, 36(3): p. 381-385.

40.    Baranauskas, G., T. Tkatch, K. Nagata, J.Z. Yeh and D.J. Surmeier, 2003

Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons.

Nature Neuroscience, 6(3): p. 258-266.

41.    Sugawara, T., Y. Tsurubuchi, T. Fujiwara, E. Mazaki-Miyazaki, K. Nagata, M. Montal, Y. Inoue and K. Yamakawa, 2003

Nav1.1 channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents.

Epilepsy Research, 54(2-3): p. 201-207.

42.    Ikeda, T., K. Nagata, Y. Kono, J.Z. Yeh and T. Narahashi, 2004

Fipronil modulation of GABAA receptor single-channel currents.

Pest Management Science, 60(5): p. 487-492.

43.    Zuo, Y., K. Nagata, J.Z. Yeh and T. Narahashi, 2004

Single-channel analyses of ethanol modulation of neuronal nicotinic acetylcholine receptors.

Alcoholism-Clinical and Experimental Research, 28(5): p. 688-696.

44.    Yamashita, M, T. Mori, K. Nagata, J.Z. Yeh, T. Narahashi, 2005

Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells.

Anesthesiology, 102(1):76-84

45.    Nagata, K., Duggan, A., Kumar, G., J. García-Añoveros, 2005

Nociceptor and hair cell tranducer properties of TRPA1, a channel for pain and hearing.

Journal of Neuroscience, 25(16): 4052-4061.        

Reviews

1.      Nagata, K., T. Miyata and T. Saito,1991

Differential toxicity of fenvalerate enantiomers.

E. Hodgson, R.M. Roe, and N. Motoyama (eds).

Pesticide and the future: toxicological studies of risks and benefits,North Carolina State University. 197-202.

2.      Narahashi, T., D.B. Carter, J. Frey, K. Ginsburg, B.J. Hamilton, K. Nagata, M.L. Roy, J.H. Song and H. Tatebayashi, 1995

Sodium channels and GABA(A) receptor-channel complex as targets of environmental toxicants.

Toxicology Letters, 82-3, 239-245.

3.      Narahashi, T., J.M. Frey, K.S. Ginsburg, K. Nagata, M.L. Roy and H. Tatebayashi, 1995

Sodium-Channels and Gamma-Aminobutyric-Acid Activated Channels as Target Sites of Insecticides.,

Molecular Action of Insecticides on Ion Channels, 591: p. 26-43.

4.      Narahashi, T., G.L. Aistrup, J.M. Lindstrom, W. Marszalec, K. Nagata, F. Wang and J.Z. Yeh, 1998

Ion channel modulation as the basis for general anesthesia.

Toxicology Letters, 101: p. 185-191.

5.      Narahashi, T., K.S. Ginsburg, K. Nagata, J.H. Song and H. Tatebayashi, 1998

Ion channels as targets for insecticides.

Neurotoxicology, 19(4-5): p. 581-590.

6.         Narahashi, T., G.L. Aistrup, W. Marszalec and K. Nagata, 1999

Neuronal nicotinic acetylcholine receptors: a new target site of ethanol.

Neurochemistry International, 35(2): p. 131-141.

7.            Narahashi, T., G.L. Aistrup, J.M. Lindstrom, W. Marszalec, H. Motomura, K. Nagata, H. Tatebayashi, F. Wang And J.Z. Yeh, 1999

Alcohol and general anesthetic modulation of GABA(A) and neuronal nicotinic acetylcholine receptors.

The Drunken Synapse, ed. Liu and Hunt, New York: Kluwer Academic/Plenum Publishers. 39-49.

8.      Narahashi, T., G.L. Aistrup, T. Ikeda, K. Nagata, J.H. Song and H. Tatebayashi, 1999

Ion channels as targets for insecticides: past, present and future.

Progress in Neuropharmacology and Neurotoxicology of Pesticide and Drugs.

9.            Narahashi, T., Y. Zuo, G.L. Aistrup, W. Marszalec, K. Nagata and J.Z. Yeh, 2003

Significance of neuronal nicotinic acetylcholine receptors in drug actions: Alocohol modulation.

Neurotoxicology, 24(2): p. 297-298.

Others

1.      Nagata, K., Studies on the mode of action of insecticides using molecular biological and electrophysiological techniques

Journal of Pesticide Science 20, 345-359.(in Japanese)

2.      Nagata, K., Nicotinic acetylcholine receptor-channels as the target of insecticides. Plant Protection, 1997. 51: p. 397-401.(in Japanese)

3.      Nagata, K., Mode of action of neuroactive insecticides. Miscellaneous Publication of the National Institute of Sericultural and Entomological Science, 1999. 25: p. 90-93.(in Japanese)

Scientific Meetings

 Nagata, K. and Narahashi, T.

Suppression of neuronal GABA-activated Cl- current by the insecticide dieldrin

Meeting of Society for Toxicology, The Toxicologist 13, 126 (1993)

Nagata, K., Narahashi, T.

Dual action of the cyclodiene insecticide dieldrin on GABA receptor chloride channel complex of rat dorsal root ganglion neurons

Abstracts of Papers American Chemical Society, 206(1-2) AGRO 65 (1993).

Nagata, K., Hamilton, B.J., Carter, D.B. and Narahashi, T.

Selective actions of dieldrin on the GABAA-receptor-channel subunits expressed in human embryonic kidney cells

Meeting of Society for Toxicology, The Toxicologist 14, 244 (1994)

Nagata, K. and Narahashi, T.

Differential effects of chlorinated hydrocarbon insecticides on the GABA receptor-chloride channel subunits

Eighth IUPAC International Congress of Pesticide Chemistry. 1, 240 (1994)

Nagata, K., Hamilton, B. J., Carter, D. B., Narahashi, T.

Differential effects of dieldrin and HCH isomers on the recombinant GABA receptor-chloride channel complex

Society for Neuroscience Abstracts. 20(1-2). 1994. 510.

Nagata, K., Narahashi, T.

Nicotinic acetylcholine receptor of PC12 cells as the target of neuroactive compounds Society for Neuroscience Abstracts. 21(1-3). 1995. 606.

Nagata, K., Marszalec, Aistrup, G. L., W., Huang, C.-S., Song, J.-H., Yeh, J. Z., Narahashi, T.

Effects of ethanol on the neuronal nicotinic acetylcholine receptor-channel complex in rat PC12 cell

Alcoholism, Clinical and Experimental Research. 20(2), 54(A)

Nagata, K., Huang, C.-S., Aistrup, G. L., Marszalec, W., Song, J.-H., Yeh, J. Z., Narahashi, T.

Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol

Society for Neuroscience Abstracts. 22(1-3). 1996. 335.

Huang, C.-S., Nagata, K., Yeh, J. Z., Narahashi, T.

Riluzole, a neuroprotective drug, blocks calcium channels in rat dorsal root ganglion neurons

Society for Neuroscience Abstracts. 22(1-3). 1996. 1750.

Song, J.-H., Nagata, K., Yeh, J. Z., Narahashi, T.

Effects of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons

Society for Neuroscience Abstracts. 22(1-3). 1996. 59.

Song, J.-H., Nagata, K., Huang, C.-S., Yeh, J. Z., Narahashi, T.

Differential block of two types of sodium channels by anticonvulsants can be explained by steady-state inactivation

Biophysical Journal. 72(2 PART 2). 1997. A360.

Nagata, K., Song, J.-H., Shono, T. and Narahashi, T.

Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nitromethylene heterocycle imidacloprid

Neurotox 98, 9 (1998)

Nagata, K., Aoyama, E., Shono, T. and Nrahashi, T.

Modulation of the neuronal nicotinic acetylcholine receptor-channel by environmental toxicants. Ion channel modulators and blockers.

Proceedings of 9th International Congress of Pesticide Chemistry Abstract. 4B-10 (1998)

Nagata, K., Shono, T., Narahashi, T.

Effects of cartap on the nicotinic acetylcholine receptor channel of PC12 cells

Society for Neuroscience Abstracts. 24(1-2). 1998. 1343.

Ikeda, T., Nakatani, K., Nagata, K., Honda, H., Shono, T., Narahashi, T.

Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons

Society for Neuroscience Abstracts. 24(1-2). 1998. 588.

Zhao, X., Nagata, K., Marszalec, W., Yeh, JZ and Narahashi, T.

Effects of insecticide DPX-MP062 on neuronal nicotinic acetylcholine and GABA receptors in mammalian neurons

Toxicological Science. 48(1-S) 102 (1999)

Nagata, K., Aistrup, G. L., Shono, T., Narahashi, T.

Direct actions of anticholinesterases on the nicotinic acetylcholine receptor of PC12 cells Society for Neuroscience Abstracts. 25(1-2). 1999. 1491.

Ikeda, T., Nagata, K., Narahashi, T.

Fipronil and dieldrin modulation of GABAA receptors in rat dorsal root ganglion neurons Society for Neuroscience Abstracts. 25(1-2). 1999. 1482.

Tsurubuchi, Y., Nagata, K., Kono, Y., Zhao, X., Narahashi, T.

Modulation of sodium channels by enantiomers of indoxacarb and RH-3421 in rat dorsal root ganglion neurons

Society for Neuroscience Abstracts. 26(1-2). 2000. Abstract No.-713.11.

Ikeda, T., Zhao, X., Nagata, K., Kono, Y., Yeh, J. Z., Narahashi, T.

Fipronil modulation of GABAA receptors in rat dorsal root ganglion neurons

Society for Neuroscience Abstracts. 26(1-2). 2000. Abstract No.-237.9.

Zhao, X., Nagata, K., Yeh, JZ and Narahashi, T.

The insecticide DPX-MP062 and its metabolite DCJW block sodium channels in mammalian neurons

Toxicological Science. 54(1) 336 (2000)

Ikeda, T., Nagata, K., Kono, Y., Yeh, JZ and Narahashi, T.

Fipronil modulation of GABA(A) receptors in rat dorsal root ganglion neurons

Toxicological Science, 54(1), 336.

Tsurubuchi, Y., Nagata, K., Sugawara, T., Imoto, K., Noda, M., Narahashi, T., Nontal, M., Hirose, S.,Yamakawa, K.

Kinetic changes of voltage-gated sodium channels by a missense mutation of alpha II subunit gene Nav1.2 in a patient with febrile and afebrile seizures

Society for Neuroscience Abstracts. 27(1). 2001. 117.