Undergraduate
Northwestern University (Honors Program in Biomedical Engineering)

Medical School
University of Wisconsin Medical School 

Residency
McGaw Medical Center of Northwestern University

Fellowship
McGaw Medical Center of Northwestern University (Cardiovascular Physiology)

Awards

National

Board of Directors, International Society for Anaesthetic Pharmacology, 2001-

Subcommittee Chair, American Society of Anesthesiologists Committee on Equipment and Facilities, 2004-

Northwestern Memorial Hospital

 Vice-Chair, P&T Executive Committee, 2004-

Chair, P&T Therapeutics Subcommittee, 2004-

Department

 Member, Executive Committee, 2001-

Chairman, Research Committee, 2001-

Publications and Peer Reviewed Articles (Past 5 Years)

Avram MJ, Krejcie TC, Henthorn TK, Niemans CU:  b-Adrenergic blockade affects initial distribution due to decreased cardiac output and altered blood flow distribution.  J Pharmacol Exp Ther.311:617-24, 2004. 

Avram MJ, Krejcie TC: Using front-end kinetics to optimize target-controlled drug infusions.  Anesthesiology. 99:1078-1086, 2003. 

Alkire MT, Krejcie TC, Avram MJ: Anesthesia induced alterations in plasma tracer concentrations may have relevance for brain imaging studies. (Letter) Anesthesiology. 97:281-282, 2002. 

Avram MJ, Krejcie TC, Henthorn TK: The concordance of early antipyrine and thiopental distribution kinetics. J Pharmacol Exp Ther. 302:594-600, 2002. 

Krejcie TC, Wang Z, Avram MJ. Drug-induced hemodynamic perturbations alter the disposition of markers of blood volume, extracellular fluid, and total body water. J Pharmacol Exp Ther 296:922-930, 2001.

Waters CM, Krejcie TC, Avram MJ. Facilitated uptake of fentanyl, but not alfentanil, by human pulmonary endothelial cells. Anesthesiology. 93:825–31, 2000.

Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ. "Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol." Clinical Pharmacology & Therapeutics. 67:342–50, 2000.

Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ. "Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol." Clin Pharmacol Ther 67:342-350, 2000.

Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK. "Isoflurane alters the recirculatory pharmacokinetics of physiological markers." Anesthesiology 92:1757-1768, 2000.

Waters CM, Krejcie TC, Avram MJ. "Facilitated uptake of fentanyl, but not alfentanil, by human pulmonary endothelial cells." Anesthesiology 93:825-31, 2000.

Abstracts (Past 5 Years)

Krejcie TC, Henthorn TK, Niemann CU, Avram MJ: Beta Blockers Alter Initial Drug Distribution by Decreasing Cardiac Output and Altering Blood Flow Distribution in Man.  Presented at the 57th Annual Meeting of the American Society of Anesthesiologists, Las Vegan, NV, Oct. 2004.

Krejcie TC, Henthorn TK, Niemann CU, Avram MJ: Beta Blockers Alter Initial Drug Distribution by Decreasing Cardiac Output and Altering Blood Flow Distribution in Man.  Presented at the 13th Annual Meeting of the International Society for Anaesthetic Pharmacology, Las Vegan, NV, Oct. 2004.  Abstract was voted as one of three finalists for the Elmer Zigmond Research

Award.Avram MJ, Henthorn TK, Niemann CU, Shanks CA, Krejcie TC: Initial antipyrine disposition in man is altered by propranolol. Clin Pharmacol Ther 75:PI-118, 2004.  Presented at the Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Miami Beach, FL, March, 2004.

McCarthy RJ, Krejcie TC, Avram MJ, Fragen RJ, Wong CA: A model that describes the relationship between propofol dose and processed EEG (SNAPTM Index) Anesthesiology 97: A-494, 2003.  Presented at the 56th Annual Meeting of the American Society of Anesthesiologists, San Francisco, CA, Oct. 2003.

Avram MJ, Krejcie TC. Initial distribution volume estimates affect the kinetic model and targeted infusions. Clin Pharmacol Ther 73:P85, 2003.  Presented at the Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Washington, DC, April, 2003.

Avram MJ, Krejcie TC: Initial distribution volume estimates affect the kinetic model and targeted infusions.  Anesthesiology 97: A-467, 2002.  Presented at the 55th Annual Meeting of the American Society of Anesthesiologists, Orlando, FL, Oct. 2002.

Scavone BM, Wong CA, Krejcie TC:  Anesthesia for postpartum tubal ligation: Utilization of an indwelling epidural catheter vs. administration of spinal anesthesia. Anesthesiology 95: A-1055, 2001.  Presented at the 54th Annual Meeting of the American Society of Anesthesiologists, New Orleans, LA, Oct. 2001.

Wong CA, Avram MJ, Krejcie TC, Kuczynski EA: The relationship between early labor neuraxial analgesia, obstetrician, and cesarean delivery.   Anesthesiology 95: A-1056, 2001.  Presented at the 54th Annual Meeting of the American Society of Anesthesiologists, New Orleans, LA, Oct. 2001.

Vidovich MI, Wong CA, Krejcie TC: Labor duration analysis:  What is the appropriate statistic?  Presented at the 33rd Annual Meeting of the Society of Obstetric Anesthesia and Perinatology, San Diego, CA, April 2001.

Book Chapters

Krejcie TC: Cauda equinal syndrome after continuous spinal anesthesia, Essentials of Pain Medicine.  Edited by:  Benzon HT, Raja SN, Molloy RE, Borsook D, Strichartz G.  New York, Churchill Livingstone, 1997.

Ovassapian A, Krejcie TC:  Conscious sedation, Fiberoptic Endoscopy and the Difficult Airway.  Second Edition, Edited by Ovassapian A.  New York, Raven Press, 1996.

Henthorn TK, Krejcie TC:  Postoperative pain management, Handbook of Chronic Pain Management.  First and Second Editions, Edited by Tollinson CD.  Baltimore, Williams and Wilkins, 1988 and 1993.      

Journal Reviewer

Anesthesiology (Michael M. Todd, MD, Editor)

Guest Editor, Anesthesia & Analgesia

 Recent Professsional Invitations

Invited Speaker, ‘Front-End Kinetics: Hitting the Target with TCI”.  Meeting on Advanced Modeling and Control in Anesthesia, Monte Verità, Switzerland, April 10th - 14th, 2005.

Panel Presentation, “Target-controlled drug delivery: Current state of the art”.  International Anesthesia Research Society, Annual Meeting, Tampa, FL, March 2004.

Panel Presentation, “Pharmaco-mythology: What is the basis of anesthetic lore?  Who cares about the first two minutes?”  American Society of Anesthesiologists, Annual Meeting, San Francisco, CA, Oct. 2003.

Visiting Professor/Grand Rounds, “Front-end Kinetics”.  Rush Medical College, Chicago, IL, November 16, 2000.

Invited Speaker/Workshop Moderator, "Fiberoptic and Laryngeal Mask Intubations". Society for Ambulatory Anesthesia, Annual Meeting, Washington, DC, May 2000.

Invited Speaker, “Front-end Kinetics”.  Society for Intravenous Anesthesia, Annual Meeting, San Francisco, CA, Oct. 2000.

Invited Speaker, “Succinylcholine in the Ambulatory Environment is Dead – Pro”.  Society for Ambulatory Anesthesia, Mid-year Meeting 2000, San Francisco, CA, Oct. 2000.