Book Chapters

Fragen RJ, Avram MJ. Barbiturates. In Anesthesia, Fifth Edition. Edited by Miller RD. New York, Churchill Livingstone, pp. 209-227, 2000.

Original, Peer-Reviewed Research Publications

Weiss M, Krejcie TC, Avram MJ: Interpretation of transit time dispersion in terms of circulatory mixing, permeation kinetics, and extravascular diffusion of indicators in the dog. (Submitted for consideration of publication).

Nitsun M, Szokol JW, Saleh HJ, Murphy GS, Vender JS, Luong L, Raikoff K, Avram MJ: Pharmacokinetics of midazolam, propofol, and fentanyl transfer into human breast milk. (Submitted for consideration of publication).

Avram MJ, Krejcie TC: Anesthesia management and perioperative mortality. (Letter) Anesthesiology (In press) 2006.

Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS, DeMuro N: Opioids and cardioprotection:  The impact of morphine and fentanyl on recovery of ventricular function following cardiopulmonary bypass. J Cardiothor Vasc Anesth (In press) 2005.

Murphy GS, Szokol JW, Nitsun M, Alspach DA, Avram MJ, Vender JS, DeMuro N, Hoff W:  Retrograde autologous priming of the cardiopulmonary bypass circuit:  Safety and impact on postoperative outcomes. J Cardiothor Vasc Anesth (In press) 2005.

Argiris A, Kut V, Luong L, Avram MJ: Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer. Invest New Drugs (In press 2005).

Murphy GS, Szokol JW, Marymont JH, Franklin M, Avram MJ, Vender JS: Residual paralysis at the time of tracheal extubation.  Anesth Analg 100:1840-1845, 2005.

Avram MJ, Krejcie TC, Henthorn TK, Niemans CU:  b-Adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution.  J Pharmacol Exp Ther, 617-624, 2004.

Murphy GS, Szokol JW, Franklin M, Marymont JH, Avram MJ, Vender JS: Postanesthesia care unit recovery times and neuromuscular blocking drugs: A prospective study of orthopedic surgical patients randomized to receive pancuronium or rocuronium. Anesth Analg 98:193-200, 2004.

Murphy GS, Szokol JW, Nitsun M, Alspach D, Avram MJ, Vender JS, Votapka T, Rosengart TK: The failure of retrograde autologous priming of the cardiopulmonary bypass circuit to reduce blood use after cardiac surgical procedures. Anesth Analg 98:1201-1207, 2004.

Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS: Retrograde air embolization during radial artery catheter flushing: An ultrasound study. Anesthesiology. 101:614-619, 2004.

Szokol JW, Murphy GS, Avram MJ, Nitsum M, Wynnychenko TM, Vender JS: Declining proportion of publications from American authors in major anesthesiology journals.  Anesth Analg 96:513-517, 2003.

Murphy GS, Szokol JW, Marymont JH, Vender JS, Avram MJ, Rosengart TK: Recovery of neuromuscular function following cardiac surgery: Pancuronium versus rocuronium.  Anesth Analg 96:1301-1307, 2003.

Avram MJ, Krejcie TC: Using front-end kinetics to optimize target-controlled drug infusions.  Anesthesiology. 99:1078-1086, 2003.

Alkire MT, Krejcie TC, Avram MJ: Anesthesia induced alterations in plasma tracer concentrations may have relevance for brain imaging studies. (Letter) Anesthesiology. 97:281-282, 2002.

Wheeler M, Birmingham PK, Dsida RM, Wang Z, Cote CJ, Avram MJ: Uptake pharmacokinetics of the fentanyl Oralet in children scheduled for central venous access removal: Implications for the timing of initiating painful procedures. Paediatr Anesth 12:596-599, 2002.

Murphy GS, Szokol JW, Vender JS, Marymont JH, Avram MJ.  The use of neuromuscular blocking agents in adult cardiac surgery: Results of a national postal survey. Anesth Analg 95:1534-1539, 2002.

Avram MJ: Evaluating clinical trials in anesthesia. (Letter) Anesthesiology 97:1032-1033, 2002.

Avram MJ, Krejcie TC, Henthorn TK: The concordance of early antipyrine and thiopental distribution kinetics. J Pharmacol Exp Ther. 302:594-600, 2002.

Dsida RM, Wheeler M, Birmingham PK, Wang Z, Heffner CL, Cote CJ, Avram MJ. Age-stratified pharmacokinetics of ketorolac tromethamine in pediatric surgical patients. Anesth Analg 94:266-270, 2002.

Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS, Rosengart TK. Impact of shorter-acting neuromuscular blocking agents on fast-track recovery of the cardiac surgical patient. Anesthesiology 96:600-606, 2002.

Wong CA, Loffredi M, Ganchiff JN, Zhao J, Wang Z, Avram MJ. Gastric emptying of water in term parturients. Anesthesiology 96:1395-1400, 2002.

Wang Z, Dsida RM, Avram MJ. Determination of ketorolac in plasma by reversed-phase high-performance liquid chromatography using solid-phase extraction and ultraviolet detection. J Chromatog B 755:383-386, 2001.

Krejcie TC, Wang Z, Avram MJ. Drug-induced hemodynamic perturbations alter the disposition of markers of blood volume, extracellular fluid, and total body water. J Pharmacol Exp Ther 296:922-930, 2001.

De Wolf AM, Fragen RJ, Avram MJ, Fitzgerald PC, Rahimi-Danesh F. The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment. Anesth Analg 93:2005-2009, 2001.

Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ. Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Clin Pharmacol Ther 67:342-350, 2000.

Avram MJ, Henthorn TK, Niemann CU, Enders-Klein C, Shanks CA, Krejcie TC. Isoflurane alters the recirculatory pharmacokinetics of physiological markers. Anesthesiology 92:1757-1768, 2000.

Waters CM, Krejcie TC, Avram MJ. Facilitated uptake of fentanyl, but not alfentanil, by human pulmonary endothelial cells. Anesthesiology 93:825-831, 2000.

 Abstracts and Presentations

Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS:  Opioids and cardioprotection: The impact of morphine and fentanyl on recovery of ventricular function following cardiopulmonary bypass. Presented at the 2005 Annual Meeting of the American Society of Anesthesiologists in Atlanta, GA. (A-342).

Nitsun M, Szokol JW, Murphy GS, Vender JS, Avram MJ: Fentanyl elimination in human breast milk. Presented at the 2005 Annual Meeting of the American Society of Anesthesiologists in Atlanta, GA. (A-567).

Benzon HT, Chew T-L, Benzon HA, Avram MJ, Robert J. McCarthy, Pharm.D: Particle sizes of long acting steroids and the effect of dilution. Presented at the 2005 Annual Meeting of the American Society of Anesthesiologists in Atlanta, GA. (A-997).

Nitsun M, Szokol JW, Saleh HJ, Murphy GS, Vender JS, Raikoff K, Avram MJ: The kinetics of propofol transfer into breast milk.  Presented at the 2005 Annual Meeting of the International Anesthesia Research Society in Honolulu, HA. (S-401)

Avram MJ, Henthorn TK, Niemann CU, Shanks CA, Krejcie TC: Initial antipyrine disposition in man is altered by propranolol. Clin Pharmacol Ther 75:PI-118, 2004.  Presented at the 2004 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Miami Beach, FL

Avram MJ, Krejcie TC. Initial distribution volume estimates affect the kinetic model and targeted infusions. Clin Pharmacol Ther 73:P85, 2003. Presented at the 2003 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Washington, D.C.

McCarthy RJ, Krejcie TC, Avram MJ, Fragen RJ, Wong CA: A model that describes the relationship between propofol dose and processed EEG (SNAP­ Index). Presented at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco, CA (A-494).

Wong CA, Fitzgerald PA, Raikoff K, Avram MJ: Gastric emptying in obese term pregnant women.  Presented at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco, CA (A-1213).

Koh E-K, Szokol JW, Muldoon JP, Avram MJ, Merwitz E: Low dose vs. standard dose bupivacaine spinal for ano-rectal surgery.  Presented at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco, CA (A-10).

Murphy GS, Szokol JW, Franklin A, Avram MJ, Vender JS:  The impact of choice of neuromuscular blocking agent on postanesthesia care unit recovery.  Presented at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco, CA (A-1136).

Wong CA, Fitzgerald PA, Raikoff K, Avram MJ: Gastric emptying in obese term pregnant women.  Anesthesiology 2003;98(Supplement 1):A23.  Presented at the 2003 Annual Meeting of the Society for Obstetric Anesthesia and Perinatology (SOAP) in Phoenix, AZ.

Avram MJ, Krejcie TC. Estimates of the initial volume of distribution of three-compartment pharmacokinetic models affect description of peripheral drug distribution. Clin Pharmacol Ther 71:P99, 2002. Presented at the 2002 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Atlanta, Georgia.

Krejcie TC, Avram MJ. Initial distribution volume estimates affect the kinetic model and targeted drug infusions. ASA, Orlando, Florida, 2002 (A-467).

Murphy GS, Szokol JW, Marymont JH, Vender JS, Avram MJ: Recovery of neuromuscular function following cardiac surgery: Pancuronium versus rocuronium. Presented at the 2002 Annual Meeting of the American Society of Anesthesiologists in Orlando, FL (A-164).

Sullivan JT, Scavone BM, Wong CA, Avram MJ. Use of IUPC to evaluate the effect of CSE on uterine contraction patterns. Anesthesiology 94(Supplement): A73, 2001. SOAP, San Diego, California, 2001.

Marcus RL, Wong CA, Strauss-Hoder T, Maly J, Cummings C, Avram M. Postoperative pain after “minor” surgery (postoperative tubal ligation) is not minor. Anesthesiology 94(Supplement):A98, 2001, SOAP, San Diego, California.

Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS. Are shorter-acting neuromuscular blocking agents associated with reductions in duration of tracheal intubation following cardiac surgery? ASA, A161, New Orleans, Louisiana, 2001. 

Wong CA, Avram MJ, Krejcie TC, Kuczynski EA. "The relationship between early labor neuraxial analgesia, obstetrician and cesarean delivery." ASA, A1056, New Orleans, Louisiana, 2001.

Sullivan JT, Scavone BM, Wong CA, Avram MJ. "The use of intrauterine pressure catheters to evaluate the effects of combined spinal-epidural analgesia on uterine contraction patterns." ASA, A1076, New Orleans,  Louisiana, 2001.

Loffredi M, Wong CA, Ganchiff JN, Zhao J, Wang Z, Avram M. Gastric emptying in ter parturients: Is NPO after midnight necessary? Anesthesiology 92(Supplement):A36, 2000, SOAP, Montreal, Quebec, Canada.

Krejcie TC, Avram MJ. "Physiologic perturbations affect the time-dependent volume of distribution." Anesthesiology 93:A534, 2000, ASA, San Francisco, CA.

Lofreddi M, Wong CA, Ganchiff JN, Zhao J, Avram MJ. Gastric emptying in term parturients: Is NPO after midnight necessary? Anesthesiology 93:A1103. ASA, San Francisco, CA, 2000.

Consultative Reviewer

1. Anesthesia and Analgesia, 1998 – present
2. Anesthesiology, 1986 – present
3. Clinical Pharmacology and Therapeutics, 2002 – present
4. J Chromatography B: Biomedical Sciences and Applications, 2001 – present
5. Journal of Pharmaceutical Sciences, 2002 – present
6. Journal of Pharmacology and Experimental Therapeutics, 1999 – present