Featured Publications

  • Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. 2011 Jul 8;146(1):37-52. PMID: 21700325
  • Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 2009 Apr 3;137(1):60-72. PMID: 19345187
  • Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. J Neurosci. 2011 Apr 20;31(16):5970-6. PMID: 21508222

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Our Center

The Center for Rare Neurological Diseases looks to examine the molecular basis of rare lysosomal diseases. We will use this research to better understand neurodegeneration, identify molecular targets, and develop therapies for both rare and common neurodegenerative diseases – including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis (ALS).

Learn more about us.

Dimitri Krainc, MD

Read a message from Center Director, Dimitri Krainc, MD, PhD