In 2016, the Northwestern Medicine Transplant Advisory Council (NMTAC), an inspired group of organ recipients, donors and their families that are united in a mission to support the future of organ transplantation at Northwestern Medicine while connecting and supporting the transplant community, Northwestern Memorial Foundation (NMF) and the Comprehensive Transplant Center (CTC) embarked on a journey to build a $10M endowment fund to support ongoing CTC research efforts. Currently the endowment principle is $1.5M and will start producing a payout in FY2018. The endowment funds will be used to support ambitious, audacious and innovative research that is not typically funded by federal agencies and industry partners but will allow the CTC scientists to explore the next generation of aspirational projects to ensure a sustainable legacy of the relentless pursuit of collaborative and innovative research that has become the hallmark of the CTC.
An advisory council was established that included CTC faculty, representing all the areas of CTC research, two members of the NMTAC, and representatives from NMF. The committee reviewed and discussed each proposal at length, using a 5 point rating scale. The evaluations were based on five criteria: scientific merit, innovation or “risk”, significance to transplant, likelihood of receiving future funding and the investigator.
Annually requests for proposals will be issued in the spring with applications due May 15 and an anticipated project/funding start date of September 1. For more information, please contact Leigh Anne Mixon (email@example.com).
FY 2020 Awardees:
- Daniel Borja-Cacho, MD: $50,000 for his project "Ex-vivo Normothermic Perfusion as a tool to improve the viability and function of marginal livers"
- Dave Pinelli, MD: $15,000 for his project "Friend or Foe: In search of acceptable HLA mismatches in solid organ transplantation"
- Jason Wertheim, MD: $28,500 for his project "Establishing an iPSC biobank from patients with liver disease"
- Kyle Koss: $5,000 for his project "Promoting Nerve Repair in a Hind Limb Transplant Model using Glial-Seeded Self-Assembling Amphiphile Scaffolds"
- Mary Hummel, MD: $21,500 for the project "Identification of receptors that mediate entry of human cytomegalovirus in hematopoietic progenitor cells"
- Taylor Heald-Sargent: $12,000 for her project "Cellular site and burden of latent CMV in donor lungs"
- Themistoklis Kourkoumpetis, MD: $8,000 for the project "The Association Between Liver and Mononuclear Cell Microbial Signatures and Acute Liver Transplant Rejection"
FY 2019 Awardees:
- Andre Iovane, PhD: $8,225 for his project "Development of a new CRISPR-based ultra-sensitive method for CMV nucleic acids detection and quantitation"
- Catherine Chapin, MD, MS: $10,000 for her project "Transcriptome analysis to identify key mediators of immune dysregulation in indeterminate pediatric acute liver failure"
- Daniela Ladner, MD, MPH: $15,000 for her project "PIPELine (Personality Informed Prehabilitation in End-stage Liver disease)"
- Robert Gerbasi, PhD: $17,000 for his project "A pilot study to delineate the proteoforms underpinning FSGS recurrence in patients after kidney allograft transplantation using next-generation precision proteomics"
- Mahzad Akbarpour, DVM, PhD: $17,775 for the project "Inflammasome-dependent IL-1B production by donor NCM lead to the development of PGD following lung transplantation"
- Michael Divito, PhD: $20,000 for his project "Optimization of Acellular Liver Scaffold System for iPSC Lipotoxicity Model"
FY 2018 Awardees:
- Mary Rinella, MD: $10,000 for her project “Noninvasive Diagnosis of Disease Recurrence in Patients Transplanted for NASH Cirrhosis”
- Katherine Hekman, MD, PhD : $9,950 for her project “Metabolic Reprogramming in Nephron Progenitor Cell Directed Differentiation”
- Sarah Taylor, MD: $10,000 for her project “The Mechanistic Implications of a Limited Immunoglobulin Repertoire in Biliary Atresia”
- Lisa Van Wagner, MD: $10,000 for her project “Change in Body Composition in Liver Transplant Recipients Over Time and Impact on Clinical Outcomes”
In the early fall, the Transplant Center received a $25,000 donation. Instead of adding this to the endowment principal, we decided to fund pilot projects in a manner consistent with how we plan to distribute the endowment payout beginning in FY2018. The purpose in funding the pilot projects was threefold: 1) to demonstrate to potential donors how the funds would be used and the process by which funds would be allocated; 2) to demonstrate to faculty members that they could benefit from this process to encourage them to direct patients who are potential donors to the endowment campaign and 3) to test the funding process. Based on these criteria, the committee decided to fund pieces of the four proposals listed below. These projects began December 1, 2016.
FY 2017 Pilot Awardees:
- Javeed Ansari, MD: $10,000 for his project “Identification and Characterization of HLA-Specific B Cells in Transplant Recipients
- Eleonora Forte, PhD: $4,000 for her project “Identification of host genes essential for Human Cytomegalovirus latency and reactivation by CRISPR-Cas9 Knockout Screening”
- John Friedewald, MD: $1,000 for his project “Clinical and Genomic Predictors of Outcomes in Kidney Transplantation”
- Silvia Minardi, PhD: $10,000 for her project “Synthosomes: Biomimetic Exosome-like Proteolipid Nanovesicles for Tolerance Delivery in an Islet Transplant Model”