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Northwestern University Feinberg School of Medicine
Stem Cells & Regenerative Biology

Our Members

Below is a list of initiative members. These members are faculty across Northwestern University that contribute to our ever-growing knowledge of stem cell and regenerative biology. View individual profiles – with publication, contact information, research and clinical specialties, and more – via the links below.

Michael Abecassis

Michael Abecassis, MD/MBA

Founding Director, Comprehensive Transplant Center
Chief of Transplant Surgery in the Department of Surgery
James Roscoe Miller Distinguished Professor of Medicine
Professor of Surgery (Organ Transplantation) and Microbiology-Immunology

Description of Interests

Dr. Abecassis’ research interests include work in molecular virology studying the molecular and epigenetic mechanisms underlying reactivation of Cytomegalovirus from latency following transplantation. In addition, Dr. Abecassis has a robust research program in biomarker discovery and functional genomics focused on predictive peripheral blood signatures for rejection in kidney and liver transplant recipients. He is also the PI on a T32 that allows for inter-disciplinary research in a number of transplant-related areas including immune tolerance,  cell-based therapies, tissue-engineered organogenesis, and health services and outcomes research focused on improving the lives of transplant recipients. The Comprehensive Transplant Center hosts a number of innovative cores and collaboratives designed to engender inter-dependent research between a number of scientific and clinical disciplines focused on advancing the field and science of transplantation.

Guillermo Ameer

Guillermo Ameer, ScD

Professor, McCormick School of Engineering/Surgery (Vascular Surgery)

Description of Interests

The Ameer research group develops regenerative engineering tools that will enable improvements in healthcare and patient quality of life by integrating biomaterials science, engineering, nanotechnology, stem cell science, and medicine. To this end, we design, synthesize, and evaluate advanced functional materials and systems to solve complex medical problems that involve the replacement, repair, or regeneration of tissues and organs. Our laboratory pioneered the development and applications biomaterials that are suitable to potentially treating injuries and disease conditions that affect blood vessels, bone, ligament, tendon, cartilage, kidney, bladder, skin, pancreas, and liver.

Our current areas of interest include on-demand patient-specific medical devices, regenerative engineering, tissue engineering, wound healing in diabetes, monitoring and controlling the foreign body response, biomaterials and cell-material interactions, and targeted delivery of therapeutic molecules, biomacromolecules, and cells.

Hossein Ardehali

Hossein Ardehali, MD/PhD

Director, Feinberg Cardiovascular Research Institute - Center for Molecular Cardiology
Professor of Medicine (Cardiology) and Pharmacology

Description of Interests

Ardehali lab works on the role of mitochondria and metabolism in cardiovascular disease.

Raj Awatramani

Raj Awatramani, PhD

Associate Professor of Neurology (Movement Disorders)

Description of Interests

  1. Mechanisms underlying dopamine neuron development, function, diversity, and degeneration.
  2. Mechanisms regulating peripheral nerve myelination in development and disease states.

Joseph Bass

Joseph Bass, MD, PhD

Director, Center for Diabetes and Metabolism
Chief of Endocrinology in the Department of Medicine
Charles F. Kettering Professorship of Medicine
Professor of Medicine (Endocrinology)

Description of Interests

Our laboratory has pioneered research on the relationship between circadian rhythms and disease by providing the first demonstration that mice with circadian gene disruption develop obesity, hyperlipidemia, and diabetes (Science, 2005). We have used genomic approaches to elucidate a central role of cell-type specific enhancers in clock control of endocrine systems important in both tissue development and function (Nature, 2010, Science 2015). We have also mapped the neuronal circuits through which the clock impacts body weight set point (Cell Metabolism, 2007). Our original contributions to understanding the mechanisms of biological timing in metabolic regulation are opening new avenues for understanding clock-­based treatments in diabetes, obesity, inflammation, and cancer.

G.R. Scott Budinger

G.R. Scott Budinger, MD

Ernest S. Baley Professor of Airway Diseases
Chief of Pulmonary & Critical Care in the Department of Medicine
Professor of Medicine in Cell and Molecular Biology

Description of Interests

Dr. Budinger’s laboratory is interested in understanding how aging biology intersects with the age-related risk of acute and chronic lung disease. They have focused on the proteostasis network, a system of proteins that is responsible for maintaining all of the proteins in the cell in their native functional state. In model organisms, there is a programmed signal that induces a progressive decline in function of the proteostasis network, and interruption of this pathway extends lifespan and improves resilience in the face of environmental stress.

The Budinger lab is testing whether a similar decline in the function of the proteostasis network happens in the lung, and whether this loss of “proteostasis reserve” underlies the increased susceptibility to pneumonia, and the increased risk of lung fibrosis and emphysema observed in older individuals. The long-term goal of this work is to develop treatments that can reduce these age-related risks and preserve lung health over the lifespan.

Paul Burridge

Description of Interests

We study the pharmacogenomics of chemotherapy-induced toxicity using hiPSC as our major model. We also work on the development of direct reprogramming and hiPSC reprogramming and differentiation methodologies. 

Navdeep  Chandel

Navdeep Chandel, PhD

David W. Cugell Professor of Medicine & Cell Biology

Description of Interests

For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. Our work has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites such as L-2-hydroxyglutarate to initiate physiological and pathological processes including hypoxic activation of HIFs, cellular differentiation, T cell activation and cancer cell proliferation. We are particularly interested in how mitochondria as signaling organelles control stem cell fate. 

Earl Cheng

Earl Cheng, MD

Founders’ Board Professor of Urology

Description of Interests

Urologic disease, bladder
Anis Contractor

Description of Interests

Research in our laboratory is directed at understanding the fundamental mechanisms of synaptic communication and how these processes go wrong in neurodevelopmental and neuropsychiatric disorders.

John Crispino

John Crispino, PhD

Robert I. Lurie, MD and Lora S. Lurie Professor
Professor of Medicine (Hematology/Oncology) and Biochemistry and Molecular Genetics

Description of Interests

My work broadly focuses on normal and malignant hematopoiesis
Conrad Epting

Conrad Epting, MD

Associate Professor of Pediatrics (Critical Care) and Pathology

Description of Interests

Strategies to promote cell and tissue regeneration remain at the forefront of cardiovascular biology. We have developed a research program exploring the response of the stem cell compartment to two critical processes; aging and heart failure, to better understand the impact of epigenetic modifications driving these acquired phenotypes in pediatric patients.  In the lab we are dissecting the epigenetic basis for cardiac stem cell activation in patients with premature ventricular failure, with an active interest to understand the impact of the paracrine milieu upon cardiac stem cell phenotype.  We have also developed the Heart Center Cardiac Biorepository to further translational research across the institution.   We hope that unraveling the regulatory pathways operative in end-stage heart failure may lead to new approaches in treatment and management to extend the lives of children and young adults with progressive heart failure from cardiomyopathy and congenital heart disease.

Amani Fawzi

Amani Fawzi, MD

Cyrus Tang and Lee Jampol Professor of Ophthalmology
Associate Professor of Opthalmology

Description of Interests

Our lab focuses on understanding the mechanisms involved in pathological retinal angiogenesis using animal models of retinal ischemia and also on studying pathways of RPE degeneration. We use a variety of techniques, including vascular and metabolic imaging and genetic manipulations in rodents in order to understand the pathways involved, and identify novel approaches for therapies.

Vasil Galat

Vasil Galat, PhD

Research Assistant Professor of Pathology

Description of Interests

The Galat laboratory at Stanley Manne Children’s Research Institute is dedicated to the study of induced pluripotent stem cells (iPSCs) aiming to provide a potential novel source of cells for the studies and treatment of human pathologies. The primarily focus is on refining directed differentiation of pluripotent stem cells to mesodermal lineages such as blood cells, vascular and mesenchymal cells with a particular emphasis on their potential use in tissue engineering and cellular therapies.

Alfred George

Alfred George, MD

Chair, Department of Pharmacology
Director, Center for Pharmacogenomics
Magerstadt Professor of Pharmacology
Professor of Pharmacology

Cara Gottardi

Cara Gottardi, PhD

Associate Professor of Medicine (Pulmonary and Critical Care)

Description of Interests

Our laboratory utilizes interdisciplinary approaches to study mechanisms of cell-cell adhesion in health and disease
Kathleen Green

Kathleen Green, PhD

Joseph L. Mayberry, Sr., Professor of Pathology and Toxicology
Professor of Pathology and Dermatology

Description of Interests

The goal of research in the Green lab is to understand how cell architecture is integrated with chemical signaling to drive tissue morphogenesis and guide differentiation programs in adult tissues, in particular regenerating tissues such as the epidermis. A major focus is on signaling functions of cadherin adhesion receptors and their associated proteins, and the pathomechanisms underlying adhesion-related diseases, including inherited skin and heart disease, autoimmune disorders and cancer. 

Alicia Guemez-Gamboa

Description of Interests

The Guemez-Gamboa lab studies the molecular bases of cellular recognition that control neural circuit assembly during development and disease. Our research program is focused on understanding how cell-surface recognition molecules mediate interactions between neurons to discriminate and select appropriate targets in the developing brain and how when these mechanisms go wrong a variety of brain connectivity defects emerge. Research approaches include molecular and cellular biology, next generation sequencing, state-of-the-art imaging techniques and the generation of disease models using mice and stem cells.

Erin Hsu

Erin Hsu, PhD

Research Assistant Professor of Orthopaedic Surgery

Description of Interests

Our Regenerative Medicine research interests are largely focused on developing novel biomaterials that promote bone and cartilage regeneration and repair. With a particular interest in spine, one overarching goal of our work is to develop translatable materials that promote spine fusion in a safer and more efficacious manner than current clinically available products.  The technologies we utilize in collaboration with materials scientists at the Simpson Querrey Institute for BioNanotechnology include stem cell-based therapies, nanotechnology-based synthetic matrices, osteoinductive 3D-printable natural and synthetic materials, and novel methodologies for scaffold-based drug delivery. 

Philip Iannaccone

Philip Iannaccone , MD/PhD

George M. Eisenberg Professor of Pediatrics
Professor of Pediatrics

Description of Interests

We are studying the genetic regulation of human GLI1 one of the transcritption factors that mediates the Hedgehog signal transduction in normal development (stem cells) and childhood cancer.

Evangelos Kiskinis

Evangelos Kiskinis, PhD

Assistant Professor of Neurology (Neuromuscular Disease) and Physiology

Description of Interests

My laboratory seeks to harness the power of pluripotent stem cells to understand how neuronal function is impaired in neurological disease. We utilize patient-specific induced pluripotent stem cells (iPSCs) and direct reprogramming methods to generate different neuronal subtypes of the central nervous system (CNS), such as motor neurons (MNs), cortical excitatory and inhibitory neurons. We study these cells by using a combination of molecular, biochemical and functional electrophysiological assays. Using these approaches, we are building three research programs: (a) developing in vitro models of pediatric epilepsies; (b) uncovering the degenerative mechanisms that give rise to amyotrophic lateral sclerosis (ALS); and (c) investigating the role of DNA methylation in human neurons. Our goal is to discover novel mechanisms of neuronal dysfunction and identify points of targeted and effective therapeutic intervention for epilepsy and ALS.

Dimitri Krainc

Dimitri Krainc, MD

Chair, Department of Neurology
Director, Center for Rare Neurological Diseases (CRND)
Aaron Montgomery Ward Professor
Professor of Neurology (Movement Disorders), Neurological Surgery, Physiology and Weinberg College of Arts and Sciences

Tsutomu Kume

Tsutomu Kume, PhD

Professor of Medicine (Cardiology) and Pharmacology

Description of Interests

Cardiovascular development is at the center of all the work that goes on in the Kume lab. The cardiovascular system is the first functional unit to form during embryonic development and is essential for the growth and nurturing of other developing organs. Failure to form the cardiovascular system often leads to embryonic lethality, and inherited disorders of the cardiovascular system are quite common in humans. The causes and underlying developmental mechanisms of these disorders, however, are poorly understood. A particular emphasis in our laboratory has recently been the study of cardiovascular signaling pathways and transcriptional regulation in physiological and pathological settings using mice as animal models, as well as embryonic stem (ES) cells as an in vitro differentiation system. The ultimate goal of our research is to provide new insights into the mechanisms that lead to the development of therapeutic strategies designed to treat clinically relevant conditions of pathological neovascularization.

Lamm Marilyn

Lamm Marilyn, PhD

Research Assistant Professor of Pediatrics (Developmental Biology)

Description of Interests

A new focus of my research is deciphering the role of the bone micro-environment in supporting the development and progression of bone metastatic carcinoma (prostate cancer) and primary bone cancer (osteosarcoma).  A major goal is to determine the regulation of collagen fibrillogenesis in bone extracellular matrix and exploit signalling interactions that underlie such regulation as potential therapeutic strategies against bone cancer and other bone-related diseases.  Additionally, understanding the regulation of bone matrix collagen fibrillar ultrastructure is crucial in the development of successful bone regeneration paradigms.
Craig Langman

Craig Langman, MD

Professor of Pediatrics (Kidney Disease)

Monica Laronda

Monica Laronda, PhD

Assistant Professor of Pediatrics (Endocrinology)

Description of Interests

The Laronda Lab investigates fundamental regenerative medicine problems using stem cells and supportive biomimetic environments. Our main objective is to develop a patient-specific ovarian follicle niche that will support systemic endocrine function and fertility in women and girls with disorders of sex development or premature ovarian failure.

Huiping Liu

Huiping Liu, MD/PhD

Associate Professor, Pharmacology and Medicine

Description of Interests

The Liu laboratory studies the molecular mechanisms underlying cancer stem cells (CSCs) and metastasis through integrated basic and translational research directions: (1) to understand CSCs in metastasis using cutting-edge single cell sequencing and gene editing technologies; (2) to image CSC behavior and interactions with immune cells during metastasis using bioluminescence imaging and intravital imaging systems; (3) to target CSCs with novel therapeutics delivered by exosomes and nanoparticles; (4) to develop circulating tumor cells (CTCs) and circulating exosome-based biomarkers for cancer diagnosis, treatment responses, and prognosis.

Yongchao Ma

Yongchao Ma, PhD

Associate Professor of Pediatrics, Neurology - Ken and Ruth Davee Department and Physiology

Description of Interests

Regulation of Motor Neuron and Dopaminergic Neuron Function in Development and Disease -------- Spinal Motor Neuron Development, Function and Degeneration in SMA and ALS: Spinal Muscular Atrophy (SMA)and Amyotrophic lateral sclerosis (ALS) are characterized by the selective degeneration of spinal motor neurons. As the leading genetic cause of infant mortality, SMA affects one in every eight thousand live births. Our group is interested in studying mechanism regulating motor neuron development and function, as well as why motor neurons specifically degenerate in SMA and ALS. To address these questions, we use a combination of genetic, biochemical and cell biological approaches, and utilize genetically modified mice, induced pluripotent stem (iPS) cells reprogrammed from fibroblasts, and zebrafish as model systems. We focus on the regulation of mitochondrial functions in SMA and ALS pathogenesis. Based on our findings, we hope to develop new therapeutic strategies for treating these diseases.
Joseph Mazzulli

Joseph Mazzulli, PhD

Assistant Professor of Neurology (Movement Disorders)

Description of Interests

The Mazzulli lab utilizes patient-derived human iPS midbrain neuronal models to examine the mechanisms of amyloid formation and toxicity in Parkinson’s disease.

Elizabeth McNally

Elizabeth McNally, MD/PhD

Director, Center for Genetic Medicine
Elizabeth J. Ward Professor of Genetic Medicine
Professor of Medicine (Cardiology) and Biochemistry and Molecular Genetics

Chad Mirkin

Chad Mirkin, PhD

Director, International Institute for Nanotechnology

Description of Interests

The Mirkin group develops nanotechnology-based drug delivery tools that address current limitations in therapeutic molecule delivery though the integration of chemistry, materials science, biology, engineering, and medicine. The group has invented and pioneered the development of Spherical Nucleic Acids (SNAs), which are a class of nanomaterials with unique chemical and biological properties that have demonstrated broad biomedical applicability. They have utilized the SNA platform to develop a co-delivery system for toll-like receptor (TLR) antagonists with the potential to control systemic and local inflammation, specifically focused on ischemia reperfusion injury in the context of surgery and organ transplantation and rejection. They have also recently demonstrated that embryonic stem cells and induced pluripotent stem cells rapidly take up SNAs and are interested in how the SNA platform may be used to efficiently deliver nucleic acids, proteins, and small molecules that control stem cell fate and function for tissue engineering applications.

Brian Mitchell

Brian Mitchell, PhD

Associate Professor of Cell and Molecular Biology

Description of Interests

The Mitchell lab uses the Xenopus embryos to understand the development and function of ciliated epithelia.  In particular, we are interested in the interplay between the cellular cytoskeleton and signaling cues that work to establish cellular and tissue polarity.  Additionally, differentiated multi-ciliated cells exist in a unique cell cycle environment that allows them to perform cellular functions that are typically restricted to cycling cells.  We use these cells to understand the relationship between the cell cycle and centriole biogenesis and maturation.

Milan Mrksich

Milan Mrksich, PhD

Professor of McCormick School of Engineering/Cell and Molecular Biology

Description of Interests

My group’s interests overlap chemistry, biology and engineering, with an emphasis on the design and synthesis of materials that are biologically active and in applications of the materials to relevant problems in the biological and medical sciences. We pioneered the design of ‘dynamic substrates’ that present ligands whose activities can be switched on and off in response to electrical or optical signals, particularly for studies that address the responses of adherent cells to changes in the extracellular matrix.  These mimics of the extracellular matrix have led the way to the discovery of novel ligands that mediate cell adhesion. 

William Muller

William Muller, MD, PhD

Magerstadt Professor of Pathology
Professor of Pathology

Description of Interests

My lab studies the molecules and signaling pathways in endothelial cells that regulate the process of transendothelial migration (diapedesis), a key step in the inflammatory response.

Panagiotis  Ntziachristos

Panagiotis Ntziachristos, PhD

Assistant Professor of Biochemistry and Molecular Genetics and Medicine (Hematology/Oncology)

Description of Interests

The Ntziachristos laboratory studies mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Important questions are related to how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to three-dimensional (3D) structure of the nucleus and cancer metabolism. In addition to understanding cancer biology these findings help us design and test targeted therapies in preclinical models of leukemia.
Guillermo Oliver

Guillermo Oliver, PhD

Director, Feinberg Cardiovascular Research Institute-Center for Vascular and Developmental Biology
Thomas D. Spies Professor of Lymphatic Metabolism
Professor of Medicine (Nephrology)

Description of Interests

The Oliver Lab focuses on understanding how each specific cell type and organ acquires all its specific and unique morphological and functional characteristics during embryogenesis. Alterations in the cellular and molecular mechanisms controlling organ formation can result in major defects and pathological alterations. Our rationale is that a better knowledge of the basic processes controlling normal organogenesis will facilitate our understanding of disease. Our goal is to dissect the specific stepwise molecular processes that make each organ unique and perfect. Our major research interests are the forebrain, visual system and the lymphatic vasculature and to address those questions we use a combination of animal models and 3D organ culture systems, stem cells and iPS cells.

Amy Paller

Amy Paller, MD

Chair, Department of Dermatology
Director, Northwestern University Skin Disease Research Center (SDRC)
Walter J. Hamlin Professor of Dermatology
Professor of Dermatology and Pediatrics (Dermatology)

Description of Interests

Dr. Paller's research interests focus on unravelling how membrane-based glycosphingolipids regulate signaling, particularly involvint the insulin-like growth factor receptor in diabetic wound healing and EGFR in skin cancer.  She has most recently uncovered a critical role for ganglioside GM3 as the mediator of diabetic insulin resistance and innervation abnormalities in skin. She has also been a leader in the application of topical nanocontructs for gene regulation in skin disorders, among them diabetic ulcers, psoriasis, atopic dermatitis, skin cancer and rare genetic disorders. Dr. Paller is the PI of Northwestern’s NIH-funded Skin Disease Research Center. The SDRC encourages interdisciplinary research and includes 3 Cores dedicated to providing service to Northwestern faculty through the development of 3D human skin equivalent models, morphologic assessment of tissues, and generation of lentiviruses for gene introduction and suppression. As director of the Pediatric Dermatology Clinical Research Unit at Northwestern and Lurie Children’s Hospital, Dr. Paller’s clinical research is centered in: defining biomarkers of inflammatory skin disorders (atopic dermatitis, ichthyoses) and initiating targeted therapy.
Christian Petersen

Christian Petersen, PhD

Assistant Professor of Molecular Biosciences

Description of Interests

The major focus of our work is understanding molecular mechanisms that enable natural adult regeneration by studying the planarian Schmidtea mediterranea. 

Susan Quaggin

Susan Quaggin, MD

Director, Feinberg Cardiovascular Research Institute
Chief of Nephrology in the Department of Medicine
Charles H. Mayo, MD, Professor
Professor of Medicine (Nephrology)

John Sarwark

John Sarwark, MD

Professor of Orthopaedic Surgery

Jeffrey Savas

Jeffrey Savas, PhD

Assistant Professor of Neurology (Movement Disorders), Medicine, Neurological Surgery, and Pharmacology

Description of Interests

Research in the Savas lab is aimed at accelerating our understanding of the proteins and proteomes responsible for neurodevelopmental and neurodegenerative diseases. We use biochemistry with discovery-based mass spectrometry (MS) to identify the protein perturbations which drive synaptopathies and proteinopathies. Groups of perturbed proteins serve as pathway beacons which we subsequently characterizes in hopes of finding new pathogenic mechanisms and potential future therapeutic targets.
H. William Schnaper

H. William Schnaper, MD

Professor of Pediatrics (Kidney Diseases)

Description of Interests

Interest: Intracellular signaling in regulation of cell phenotype and fibrogenesis
Evan Scott

Evan Scott, PhD

Assistant Professor of Biomedical Engineering

Arun Sharma

Arun Sharma, PhD

Research Associate Professor of Urology

Description of Interests

Our research focus is regenerative medicine, specifically tissue engineering and biomaterials in urologic, gastrointestinal and vascular regeneration models. We study the regenerative applications of combining novel elastomeric scaffolds with specific stem and progenitor cell populations, and utilize nanomolecules and small molecules to customize microenvironments suited to specific regenerative processes.

Hans-Georg Simon

Hans-Georg Simon, PhD

Associate Professor of Pediatrics (Developmental Biology)

Description of Interests

The Simon laboratory investigates limb and heart regeneration in regeneration-competent amphibians to develop a blueprint for strategies enhancing regenerative capacities in mammals.

Beatriz  Sosa-Pineda

Description of Interests

My research focuses on addressing 3 important issues: 1) What are the mechanisms connecting morphogenesis and cell differentiation in the developing liver and pancreas? 2) How are developmental processes utilized during regeneration and in certain diseases in the pancreas and liver? How can we apply the information gained from our studies in embryology to produce liver and pancreatic cell types from iPSCs/ESCs?

Samuel Stupp

Samuel Stupp, PhD

Director, Louis A. Simpson and Kimberly K. Querrey Institute for BioNanotechnology in Medicine (SQI)
Professor of McCormick School of Engineering and Medicine (Endocrinology)

Description of Interests

Samuel Stupp’s research focuses on supramolecular self-assembly as a strategy to create bioactive materials and nanostructures for regenerative medicine and targeted therapies. 

D. James Surmeier

D. James Surmeier, PhD

Chair, Department of Physiology
Nathan Smith Davis Professor of Physiology
Professor of Physiology

Description of Interests

Our lab is focused on the neurobiological substrates of Parkinson’s disease, Huntington’s disease and chronic pain. In addition to using modern electrophysiological, optical and genetic tools to characterize how neurons and networks adapt in these disease states, our group is working on the mechanisms underlying pathogenesis, particularly in Parkinson’s disease.

C. Shad Thaxton

Description of Interests

The Thaxton Lab focuses on the synthesis and characterization of biomimetic nanoparticles for diagnostic and therapeutic applications.
Edward Thorp

Description of Interests

We investigate basic mechanisms and therapeutic potential of myeloid cells during cardiovascular inflammation, repair, and regeneration

Jacek Topczewski

Jacek Topczewski, PhD

Research Associate Professor of Pediatrics (Developmental Biology)

Description of Interests

The Topczewski laboratory uses zebrafish models to understand processes controlling formation, differentiation, and morphogenesis of vertebrate skeleton.

Marie-Pier Tétreault

Marie-Pier Tétreault, PhD

Assistant Professor of Medicine (Gastroenterology and Hepatology)

Description of Interests

The Tetreault Lab uses novel mouse models and three-dimensional organotypic culture to delineate the reciprocal contributions of the epithelium and the microenvironment to inflammatory diseases of the gastrointestinal tract.  

John Varga

John Varga, MD

Director, Northwestern Scleroderma
John and Nancy Hughes Distinguished Professor of Rheumatology
Professor of Medicine (Rheumatology) and Dermatology

Description of Interests

My lab focuses on fibrosis of the skin, lungs and other organs. We use cell-based assays, mouse models, ex vivo organoids and human samples. Our goal is to identify novel targets for blocking fibrosis, and promoting regeneration. We apply a bench to bedside approach with early clinical trials of novel agents that promote regeneration or block fibrosis

Nicholas Volpe

Nicholas Volpe, MD

Chair, Department of Ophthalmology
George S. and Edwina Tarry Professor of Ophthalmology
Professor of Ophthalmology

Eric Weiss

Eric Weiss, PhD

Director, High Throughput Analysis Lab
Associate Professor of Molecular Biosciences, Weinberg College of Arts and Sciences

Description of Interests

Weiss’s laboratory focuses on how protein kinase signaling pathways coordinate cytoskeleton organization, membrane traffic, and gene expression to define cell architecture. The Weiss lab's present work is concentrated on understanding the functions of p21-activated kinases (PAKs) and the Ndr/warts family kinase Cbk1. The PAKs and Cbk1 play important roles in the cell cycle. Understanding how any protein kinase relays information requires identification of its regulatory partners and downstream phosphorylation targets.
Jason Wertheim

Jason Wertheim, MD, PhD

Assistant Professor of Surgery (Organ Transplantation) and McCormick School of Engineering

Description of Interests

The Wertheim lab conducts research at the intersection of stem cell biology, tissue bioengineering, regenerative medicine, and organ transplantation. The technical goals of our research are to synthesize replacement tissues that restore organ function, while the scientific goals are to develop the tools, such as specialized cells and biomaterials, and to uncover the critical knowledge describing mechanisms that instruct tissues to regenerate and regain function.

Lisa Wilsbacher

Lisa Wilsbacher, MD/PhD

Assistant Professor of Medicine (Cardiology) and Pharmacology

Description of Interests

We investigate the roles of G protein-coupled receptors in cardiac development and cardiac fibrosis.
Youyang Zhao

Youyang Zhao, PhD

Professor of Pediatrics (Critical Care) and Pharmacology

Description of Interests

Recovery of endothelial barrier integrity after vascular injury is vital for endothelial homeostasis and resolution of inflammation. A part of the research in my lab, employing genetically modified mouse models of human diseases, endothelial progenitor cells/stem cells, and translational research approach, is to elucidate the molecular mechanisms of endothelial regeneration and resolution of inflammatory injury and determine how aging and epigenetics regulate these processes . We are also studying the mechanisms of actions of the protective role of adult stem cells in sepsis and acute lung injury and how pulmonary vascular niche regulates lung regeneration.