This page lists the various basic science research operations within the Department of Obstetrics and Gynecology Labs by lab director. Visit the individual pages for more information on each lab by clicking the faculty member's name (below).
Basic Science Research Areas/Interests
Steroid biochemistry; estrogen biosynthesis; disease progenitor cells and epigenetic defects in endometriosis, leiomyomata and breast cancer; progesterone receptors in endometriosis and leiomyomas; use of aromatase inhibitors in the treatment of endometriosis and leiomyomata
Mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription; identifying and characterizing the role of chromatin signal transducer proteins including the recently identified INHAT proteins in gene regulation
Elucidating mechanisms of hormone action in reproductive tissues and its diseases in a context dependent manner; role of hyperactivated AKT pathway in endometrial cancer and uterine fibroids, and how this signaling pathway influences hormone receptor action, specifically, progesterone receptor (PR)
Epigenetic defects and tumor progenitor cells in ovarian cancer
Defining the molecular mechanisms of breast tumor initiation, progression, and metastasis, and identifying novel targets for therapeutic development. The laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer metastasis.
Understanding development of the ovarian follicle, identifying markers and determinants of egg quality, and discovering how this basic biology can be applied to patients. This research includes the biological, cellular, and molecular mechanisms that regulate the development of the ovarian follicle, such as the study of endocrine, structural, and other environmental cues in the ovary, and an understanding of cell death within the follicle and supporting cells