The laboratory research of Serdar E. Bulun, MD, studies steroid hormone action and production in hormone-dependent human diseases such as endometriosis, uterine fibroids, and skeletal muscle atrophy. The lab is studying endometriosis research, which has informed the introduction of aromatase inhibitors into endometriosis treatment. Using human tissues and a primate model, the group has examined the cellular and molecular mechanisms responsible for the development of endometriosis. In particular, the lab members uncovered genome-wide epigenetic defects in stromal cells leading to estrogen-driven inflammation and progesterone resistance in endometriosis. The role of progesterone action and tissue stem cells are also studied in uterine fibroids, benign tumors that require progesterone for growth. The lab currently concentrates on the interaction between mutated genes and progesterone receptors that drive uterine fibroid growth. Recently, the lab used a mouse model and human tissues to demonstrate that excess estrogen via estrogen receptor-α causes lower skeletal muscle atrophy and inguinal hernia, which can be treats with an aromatase inhibitor. The lab has identified novel mutations that cause familial excessive estrogen formation syndrome.
Learn more about the Bulun Laboratory:
Serdar E. Bulun, MD