Northwestern University Feinberg School of Medicine

Center for Diabetes and Metabolism

Clinical Trials

The Center for Diabetes and Metabolism has numerous active clinical trials. Learn more about the current active protocols and participation opportunities via the list of below.

Northwestern University

PICoordinatorStudy Description
Grazia Aleppo, MDElaine Massaro
e-massaro( at )

Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes (DEPICT 2)

This study is a multicenter, randomized, double-blind, placebo-controlled, parallel group, phase 3 study to evaluate the efficacy and safety of Dapagliflozin, a SGLT2 inhibitor medication as an add-on to insulin therapy in subjects with Type 1 diabetes mellitus.

Mark E Molitch, MDMariana Johns
mk-johnson( at )

Diabetes Prevention Program Outcomes Study (DPPOS) Phase 3-Research Project

This study will examine the long-term effects of the early use – starting before diabetes develops – of metformin and lifestyle changes on development of significant morbidities such as cancer and cardiovascular disease, and help understand the clinical course of abnormal glucose levels from the pre-diabetic state through early and more advanced T2D.

Mark E Molitch, MDDaphne Adelman
d-adelman( at )

Urinary Renin Angiotensin System in Diabetes

Angiotensinogen and renin will be measured in urine samples from participants of the Diabetes Control and Complications Trial (DCCT) study under the hypothesis that these two urine analytes will provide an early signature of kidney RAS system activation that antedates albuminuria in subjects with type 1 diabetes. Moreover, it is hypothesized that improved metabolic control, as provided by intensive insulin therapy, exerts a more effective suppressive effect on urinary angiotensinogen and/or renin RAS as compared to conventional insulin therapy.

Lurie Children's Hospital

PICoordinatorStudy Description
Wendy Brickman, MDPaula Petrie, RN, CDE
pipetrie( at )

Long-Term Investigative Follow-Up in TrialNet (LIFT) Study

This study is monitoring people early in the disease process immediately following diagnosis, as well as provides follow-up to those previously enrolled in TrialNet new onset diabetes studies.


Wendy Brickman, MDPaula Petrie, RN, CDE
pipetrie( at )

Pathway to Prevention

This study screens and observes relatives of people with type 1 diabetes to learn more about how the disease occurs.