Northwestern University Feinberg School of Medicine
Driskill Graduate Program in Life Sciences
Hidayatullah G Munshi, MD

Hidayatullah G Munshi, MD

Professor of Medicine (Hematology and Oncology)

Focus of Work

Academic Focus

I have a long-term interest in understanding the role of the pronounced collagen-rich stromal reaction that is present in human pancreatic tumors. We have shown that the cancer cells upregulate the key collagenase MT1-MMP to invade and grow in 3D collagen. Recently, we developed a novel method to track cell invasion in 3D collagen using MT1-MMP-expressing cancer cells and found that Ga13 and DDR1-Par3 signaling differentially mediate invasion in the collagen-rich microenvironment.

Besides stud...[Read full text]
I have a long-term interest in understanding the role of the pronounced collagen-rich stromal reaction that is present in human pancreatic tumors. We have shown that the cancer cells upregulate the key collagenase MT1-MMP to invade and grow in 3D collagen. Recently, we developed a novel method to track cell invasion in 3D collagen using MT1-MMP-expressing cancer cells and found that Ga13 and DDR1-Par3 signaling differentially mediate invasion in the collagen-rich microenvironment.

Besides studying the mechanisms by which collagen microenvironment regulates invasion, we are also interested in understanding the role of the collagen microenvironment in treatment resistance, and have shown that epigenetic changes induced by the collagen microenvironment contribute to resistance to chemotherapy. We have found that collagen microenvironment induces histone acetylation and that targeting “readers” of histone acetylation marks using BET inhibitors can limit growth of pancreatic cancer cells. We are currently evaluating BET inhibitors in mouse models of pancreatic cancer with the goal of eventually translating these inhibitors to studies in pancreatic cancer patients. Our ongoing work suggests that BET inhibitors, a number of which are currently being evaluated in clinical trials, will have to be combined with other therapies for maximal clinical efficacy.

Finally, we have begun studies evaluating how the collagen microenvironment regulates mRNA translation to mediate pancreatic cancer progression. We have found that pharmacologic and genetic targeting of MNKs, which regulate mRNA translation, can block pancreatic cancer development and progression. We are working to translate these results with BET and MNK inhibitors into clinical trials for patients with pancreatic cancer.[Shorten text]

Keywords

Select a keyword to see all related Feinberg faculty via the main faculty profile site.


Education and Certification

  • MD: Harvard University (1996)
  • Residency: University of Washington Medical Center (1999)
  • Fellowship: University of Michigan Health System (2000)
  • Fellowship: Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) (2002)
  • Board Certification: Hematology, Internal Medicine, Medical Oncology

Contact

312/695-6180

Robert H Lurie Medical Research Center Room 3-117
303 E Superior
Chicago IL 60611

 
 

Follow DGP on