Northwestern University Feinberg School of Medicine

Department of Dermatology

Epidermal Cell-Cell Adhesion, Communication, Migration, and Differentiation/ Wound Healing

To maintain epidermal integrity and homeostasis, proper cell-cell adhesion and communication are critical. For the epidermis to fulfill its primary protective function, the orderly complex process of differentiation, which results in the formation of the outermost stratum corneum must occur. To respond to wounding, the epidermis must undergo proliferation and migration.  Several laboratories (listed below) within the dermatology department are investigating the roles of epidermal proteins and glycolipids in these biological processes, and applying them to translational mouse models. The expertise in epidermal cell biology underlies Northwestern's Skin Disease Research Center (SDRC), one of six NIH-funded SDRC's in the US.