News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s basic science academic departments. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards and honors.
Biochemistry and Molecular Genetics
- 09.03.2021Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template.
- 06.09.2021Northwestern Medicine scientists have described a method of reconstructing the three-dimensional structure of chromosomes in cancer cells and matching those chromosomes with counterpart oncogenes.
- 06.03.2021Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, has been honored with the Early Career Award for Scientists and Engineers from the U.S. Army Research Office.
Cell and Developmental Biology
A novel combination treatment may increase the ability of monoclonal antibodies to control viral infection in patients diagnosed with HIV, according to a Northwestern Medicine study.
An international collaboration for which Luisa Iruela-Arispe, PhD, chair of Cell and Developmental Biology, serves as North American coordinator, has received a five-year, $7 million Transatlantic Networks of Excellence Program award from the Leducq Foundation.
Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture.
- 09.21.2021A Q&A with Hank Seifert, PhD, the John Edward Porter Professor of Biomedical Research and professor of Microbiology-Immunology.
In a new Northwestern Medicine study in mice, researchers took one of the current vaccines, which is based on the novel coronavirus’ infamous spike protein, and added a different antigen, the nucleocapsid protein, to form a new, potentially improved version of the COVID vaccine. The nucleocapsid protein, which is an internal RNA-binding protein, may help kick the immune system into high gear much more quickly than the spike protein is capable of since it is among the most rapidly and highly expressed proteins in coronaviruses.
“At this point, we’re just trying to figure out ‘What should the 2.0 vaccines be?’” said senior and corresponding study author Pablo Penaloza-MacMaster, PhD, assistant professor of microbiology-immunology at Northwestern University Feinberg School of Medicine. “It seems like adding nucleocapsid to the vaccine renders it more protective, relative to having only the spike.”
Inefficient cardiac repair after heart attacks is partially driven by a maladapted response to a low oxygen environment by immune cells, according to a study published in the Journal of Experimental Medicine.
Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder.
Circulating tumor cells use the surface protein ICAM1 to strengthen stem cell programs and facilitate formation of tumor cell clusters, which can travel from primary tumors to other organs in the body.
In collaboration with Northwestern Medicine investigators, an international multi-center study has identified genetic factors associated with SARS-CoV-2 infection and COVID-19 severity.
A unique interaction between an excitatory neural receptor and a chloride transporter are critical for development of adult-born neurons in the dentate gyrus, according to a Northwestern Medicine study published in Cell Reports.
A region of the hippocampus known as the dentate gyrus is one of the few locations in the brain where new neurons are continuously born. The current study sheds new light on some of the mechanisms required for proper development and synaptic integration of the adult-born neurons, according to Anis Contractor, PhD, professor of Neuroscience and senior author of the study.
Neurons in the hippocampus encode a spatial map of learned knowledge, helping humans and other mammals navigate the world, according to a study published in Nature.