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Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Lou and Jean Malnati Brain Tumor Institute
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Recent Publications

  1. McCord M, Lukas RV, Amidei C, Demars N, Gelb A, Buck J, Sachdev S, Feldman A, Tate M, Dixit K  et al.  Disappearance of MMR-deficient subclones after controlled IL-12 and PD-1 inhibition in a glioma patient.  Neurooncol Adv  ;3(1):vdab045. doi:10.1093/noajnl/vdab045
  2. Baisiwala S, Budhiraja S, Goel C, Nandoliya KR, Saathoff MR, Ahmed AU  Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression.  Stem Cell Rev Rep  2021 Jul 09;. doi:10.1007/s12015-021-10195-x
  3. Lukas RV  Essential Oils for Blood-Brain Barrier Disruption: Preclinical Studies of NEO100 in Breast Cancer Brain Metastases.  Neuro Oncol  2021 Jul 09;. pii:noab167
  4. He J, Li X, Yang S, Li Y, Lin X, Xiu M, Li X, Liu Y  Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease.  Food Funct  2021 Jul 07;. doi:10.1039/d1fo00847a
  5. Jia DT, Jacobs CS, Tang M, Shaibani A, Lukas RV  The Spinal Dural Arteriovenous Fistula in a Patient With Metastatic Renal Cell Carcinoma.  Cureus  2021 May 28;13(5):e15303. doi:10.7759/cureus.15303
  6. Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC  et al.  Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.  Lancet Oncol  2021 Jun 29;. pii:S1470-2045(21)00245-X
  7. Wang G, Zannikou M, Lofchy L, Li Y, Gaikwad H, Balyasnikova IV, Simberg D  Liposomal Extravasation and Accumulation in Tumors as Studied by Fluorescence Microscopy and Imaging Depend on the Fluorescent Label.  ACS Nano  2021 Jul 01;. doi:10.1021/acsnano.1c02982
  8. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G  et al.  The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.  Neuro Oncol  2021 Jun 29;. pii:noab106
  9. Alexiev BA, Finkelman BS, Streich L, Bautista MM, Pollack SM, Jennings LJ, Brat DJ  Solitary fibrous tumor of thoracic cavity, extra-thoracic sites and central nervous system: Clinicopathologic features and association with local recurrence and metastasis.  Pathol Res Pract  2021 Jun 18;224:153531. pii:S0344-0338(21)00192-8
  10. Cai J, Zeng C, Hua W, Qi Z, Song Y, Lu X, Li D, Zhang Z, Cui X, Zhang X  et al.  An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomas.  Neurooncol Adv  ;3(1):vdab049. doi:10.1093/noajnl/vdab049
  11. Zhou Z, McDougald D, Meshaw R, Balyasnikova I, Zalutsky MR, Vaidyanathan G  Labeling single domain antibody fragments with 18F using a novel residualizing prosthetic agent - N-succinimidyl 3-(1-(2-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-5-(guanidinomethyl)benzoate.  Nucl Med Biol  2021 Jun 11;100-101:24-35. pii:S0969-8051(21)00484-4
  12. Singer LS, Feldman AZ, Buerki RA, Horbinski CM, Lukas RV, Stupp R  The impact of the molecular classification of glioblastoma on the interpretation of therapeutic clinical trial results.  Chin Clin Oncol  2021 Jun 02;. pii:cco-21-33
  13. Callmann CE, Kusmierz CD, Dittmar JW, Broger L, Mirkin CA  Impact of Liposomal Spherical Nucleic Acid Structure on Immunotherapeutic Function.  ACS Cent Sci  2021 May 26;7(5):892-899. doi:10.1021/acscentsci.1c00181
  14. Elghetany MT, Ho JM, Shi-Qi LH, Karthik S, Su JMF, Lin Q, Du Y, Shen J, Chow WY, Lau CC  et al.  Maximizing the potential of aggressive mouse tumor models in preclinical drug testing.  Sci Rep  2021 Jun 02;11(1):11580. doi:10.1038/s41598-021-91167-6
  15. Wang J, Huang TY, Hou Y, Bartom E, Lu X, Shilatifard A, Yue F, Saratsis A  Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.  Sci Adv  2021 Jun;7(23). pii:eabg4126
  16. Mohiuddin S, Maraka S, Usman Baig M, Gupta S, Muzzafar T, Valyi-Nagy T, Lindsay H, Moody K, Razvi S, Paulino A  et al.  Case series of diffuse extraneural metastasis in H3F3A mutant high-grade gliomas: Clinical, molecular phenotype and literature review.  J Clin Neurosci  2021 Jul;89:405-411. pii:S0967-5868(21)00251-4
  17. Singh R, Lehrer EJ, Wang M, Perlow HK, Zaorsky NG, Trifiletti DM, Bovi J, Navarria P, Scoccianti S, Gondi V  et al.  Dose Escalated Radiation Therapy for Glioblastoma Multiforme: An International Systematic Review and Meta-Analysis of 22 Prospective Trials.  Int J Radiat Oncol Biol Phys  2021 May 12;. pii:S0360-3016(21)00488-0
  18. Lin NU, Pegram M, Sahebjam S, Ibrahim N, Fung A, Cheng A, Nicholas A, Kirschbrown W, Kumthekar P  Pertuzumab Plus High-Dose Trastuzumab in Patients With Progressive Brain Metastases and HER2-Positive Metastatic Breast Cancer: Primary Analysis of a Phase II Study.  J Clin Oncol  2021 May 04;:JCO2002822. doi:10.1200/JCO.20.02822
  19. Fares J, Ulasov I, Timashev P, Lesniak MS  Emerging principles of brain immunology and immune checkpoint blockade in brain metastases.  Brain  2021 May 07;144(4):1046-1066. doi:10.1093/brain/awab012
  20. Li ZY, Morman RE, Hegermiller E, Sun M, Bartom ET, Maienschein-Cline M, Sigvardsson M, Kee BL  The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.  J Exp Med  2021 Jun 07;218(6). pii:e20202032
  21. Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS  et al.  De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.  Brain  2021 May 07;144(4):1230-1246. doi:10.1093/brain/awab020
  22. Tsang DS, Vargo JA, Goddard K, Breneman JC, Kalapurakal JA, Marcus KJ  Palliative radiation therapy for children with cancer.  Pediatr Blood Cancer  2021 May;68 Suppl 2:e28292. doi:10.1002/pbc.28292
  23. Platten M, Friedrich M, Wainwright DA, Panitz V, Opitz CA  Tryptophan metabolism in brain tumors - IDO and beyond.  Curr Opin Immunol  2021 Apr 01;70:57-66. pii:S0952-7915(21)00025-X
  24. Babak MV, Chong KR, Rapta P, Zannikou M, Tang HM, Reichert L, Chang MR, Kushnarev V, Heffeter P, Meier-Menches SM  et al.  Interfering with Metabolic Profile of Triple-Negative Breast Cancers Using Rationally Designed Metformin Prodrugs.  Angew Chem Int Ed Engl  2021 06 07;60(24):13405-13413. doi:10.1002/anie.202102266
  25. Zhao Y, Li X, Huang H, Zhang W, Zhao S, Makkie M, Zhang M, Li Q, Liu T  4D Modeling of fMRI Data via Spatio-Temporal Convolutional Neural Networks (ST-CNN).  IEEE Trans Cogn Dev Syst  2020 Sep;12(3):451-460. doi:10.1109/tcds.2019.2916916
  26. Cao TQ, Dixit K, Santa-Maria C, Kumthekar P  Factors affecting time to brain metastases for stage 2 and 3 breast cancer patients: A large single-institutional analysis with potential screening implications.  Neurooncol Adv  ;3(1):vdab009. doi:10.1093/noajnl/vdab009
  27. Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R  et al.  A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.  Sci Transl Med  2021 03 10;13(584). pii:eabb3945
  28. Goenka A, Tiek D, Song X, Huang T, Hu B, Cheng SY  The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma.  Cells  2021 Feb 24;10(3). pii:484
  29. Gao X, Xia X, Li F, Zhang M, Zhou H, Wu X, Zhong J, Zhao Z, Zhao K, Liu D  et al.  Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.  Nat Cell Biol  2021 03;23(3):278-291. doi:10.1038/s41556-021-00639-4
  30. Xuan W, Lesniak MS, James CD, Heimberger AB, Chen P  Context-Dependent Glioblastoma-Macrophage/Microglia Symbiosis and Associated Mechanisms.  Trends Immunol  2021 04;42(4):280-292. pii:S1471-4906(21)00028-4
  31. Li D, Bonner ER, Wierzbicki K, Panditharatna E, Huang T, Lulla R, Mueller S, Koschmann C, Nazarian J, Saratsis AM  Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR.  Sci Rep  2021 Mar 03;11(1):5098. doi:10.1038/s41598-021-84513-1
  32. Pituch KC, Zannikou M, Ilut L, Xiao T, Chastkofsky M, Sukhanova M, Bertolino N, Procissi D, Amidei C, Horbinski CM  et al.  Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity.  Proc Natl Acad Sci U S A  2021 Mar 02;118(9). pii:e2015800118
  33. Gao XY, Zang J, Zheng MH, Zhang YF, Yue KY, Cao XL, Cao Y, Li XX, Han H, Jiang XF  et al.  Temozolomide Treatment Induces HMGB1 to Promote the Formation of Glioma Stem Cells via the TLR2/NEAT1/Wnt Pathway in Glioblastoma.  Front Cell Dev Biol  2021;9:620883. doi:10.3389/fcell.2021.620883
  34. Dirven L, Musoro JZ, Coens C, Reijneveld JC, Taphoorn MJB, Boele FW, Groenvold M, van den Bent MJ, Stupp R, Velikova G  et al.  Establishing anchor-based minimally important differences for the EORTC QLQ-C30 in glioma patients.  Neuro Oncol  2021 Feb 18;. pii:noab037
  35. Miska J, Rashidi A, Lee-Chang C, Gao P, Lopez-Rosas A, Zhang P, Burga R, Castro B, Xiao T, Han Y  et al.  Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma.  Sci Adv  2021 Feb;7(8). pii:eabc8929
  36. Huang D, Lukas RV  Complete Bilateral Hippocampal Diffusion Restriction and Reversible Amnesia Following Opiate, Cocaine, and Benzodiazepine Abuse.  Cureus  2021 Jan 12;13(1):e12651. doi:10.7759/cureus.12651
  37. Huang T, Cheng SY  Targeting phospholipid metabolism for glioblastoma therapy.  Neuro Oncol  2021 03 25;23(3):343-344. doi:10.1093/neuonc/noaa309
  38. Mattox AK, Yang B, Douville C, Lo SF, Sciubba D, Wolinsky JP, Gokaslan ZL, Robison J, Blair C, Jiao Y  et al.  The mutational landscape of spinal chordomas and their sensitive detection using circulating tumor DNA.  Neurooncol Adv  ;3(1):vdaa173. doi:10.1093/noajnl/vdaa173
  39. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A  et al.  PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.  Mol Cell  2021 03 18;81(6):1276-1291.e9. pii:S1097-2765(21)00015-0
  40. Virgo KS, Rumble RB, de Wit R, Mendelson DS, Smith TJ, Taplin ME, Wade JL, Bennett CL, Scher HI, Nguyen PL  et al.  Initial Management of Noncastrate Advanced, Recurrent, or Metastatic Prostate Cancer: ASCO Guideline Update.  J Clin Oncol  2021 Apr 10;39(11):1274-1305. doi:10.1200/JCO.20.03256
  41. Katagi H, Takata N, Aoi Y, Zhang Y, Rendleman EJ, Blyth GT, Eckerdt FD, Tomita Y, Sasaki T, Saratsis AM  et al.  Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma.  Neuro Oncol  2021 Jan 20;. pii:noab009
  42. Shaik S, Maegawa S, Haltom AR, Wang F, Xiao X, Dobson T, Sharma A, Yang Y, Swaminathan J, Kundra V  et al.  REST promotes ETS1-dependent vascular growth in medulloblastoma.  Mol Oncol  2021 May;15(5):1486-1506. doi:10.1002/1878-0261.12903
  43. Fares J, Cordero A, Kanojia D, Lesniak MS  The Network of Cytokines in Brain Metastases.  Cancers (Basel)  2021 Jan 05;13(1). pii:E142
  44. Coomans MB, Dirven L, Aaronson NK, Baumert BG, van den Bent M, Bottomley A, Brandes AA, Chinot O, Coens C, Gorlia T  et al.  Calculating the net clinical benefit in neuro-oncology clinical trials using two methods: quality-adjusted survival effect sizes and joint modeling.  Neurooncol Adv  ;2(1):vdaa147. doi:10.1093/noajnl/vdaa147
  45. Shi W, Blumenthal DT, Bush NAO, Kebir S, Lukas RV, Muragaki Y, Zhu JJ, Glas M  Correction to: Global post‑marketing safety surveillance of Tumor Treating Fields (TTFields) in patients with high‑grade glioma in clinical practice.  J Neurooncol  2021 Jan;151(2):339. doi:10.1007/s11060-020-03681-8
  46. Brahmbhatt N, Stupp R, Bushara O, Bachman E, Schuele SU, Templer JW  Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy.  J Neurooncol  2021 Jan;151(2):287-293. doi:10.1007/s11060-020-03664-9
  47. Mäe MA, He L, Nordling S, Vazquez-Liebanas E, Nahar K, Jung B, Li X, Tan BC, Chin Foo J, Cazenave-Gassiot A  et al.  Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.  Circ Res  2021 Feb 19;128(4):e46-e62. doi:10.1161/CIRCRESAHA.120.317473
  48. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ  et al.  Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.  Neuro Oncol  2021 03 25;23(3):356-375. doi:10.1093/neuonc/noaa277
  49. Qi L, Kogiso M, Du Y, Zhang H, Braun FK, Huang Y, Teo WY, Lindsay H, Zhao S, Baxter P  et al.  Corrigendum to "Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors" [Cancer Lett. 493 (2020) 197-206].  Cancer Lett  2021 Mar 01;500:294. pii:S0304-3835(20)30657-1
  50. Eckerdt FD, Bell JB, Gonzalez C, Oh MS, Perez RE, Mazewski C, Fischietti M, Goldman S, Nakano I, Platanias LC  Combined PI3Kα-mTOR Targeting of Glioma Stem Cells.  Sci Rep  2020 12 14;10(1):21873. doi:10.1038/s41598-020-78788-z
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.
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