Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Lou and Jean Malnati Brain Tumor Institute

Daniel Brat, MD, PhD

Professor, Pathology; Feinberg School of Medicine

Daniel Brat, MD, PhD

Research Program


daniel.brat( at )

Selected Publications

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Cancer-Focused Research

We investigate mechanisms of progression to glioblastoma (GBM), the highest grade and most malignant form of primary brain tumor. We use mouse models and Drosophila, as well as human specimen to determine factors that promote progression, including genetics, hypoxia, the tumor micro-environment and glioma stem cells. CURRENT PROJECTS: (1) In vivo multiphoton investigation of how tumor necrosis causes enrichment of glioma stem cells and the influx of tumor associated macrophages. (2) Uncovering mechanisms that lead to altered asymmetrical cell division in brain tumor stem cells. (3) Using machine learning approaches with large molecular and histologic data sets to discover features associated with disease progression.

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