Rintaro Hashizume, MD, PhD
Assistant Professor, Biochemistry and Molecular Genetics; Feinberg School of Medicine
My primary research interests in understanding of the molecular mechanisms, that affect the aggressive/infiltrative biological behavior of malignant brain tumor and would accordingly reveal potential therapeutic targets for cancer therapy. My laboratory employs the latest genomic/epigenomic technologies to identify new therapeutic targets, and test the anti-tumor activity of the therapeutics using patient-derived pediatric brain tumor mouse model system. Our current efforts have been to identify epigenetic targets in pediatric brain tumors. I have a broad background in molecular biology and biochemistry, with specific training and expertise in rodent surgery and xenograft models. I expanded my research to include understanding molecular mechanisms and developing animal model of pediatric brain tumor for pre-clinical testing of molecular targeting therapeutics. As PIor co-Investigator on previous University-and NIH-funded grants, I laid the groundwork for the proposed research by developing suitable animal model of pediatric brain tumors and testing new molecular targeting drugs. In summary, I have a demonstrated record of successful and productive research projects in an area of brain tumor research, and my expertise and experience allow me to investigate and assess the proposed project.