Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Lou and Jean Malnati Brain Tumor Institute

Rintaro Hashizume, MD, PhD

Assistant Professor, Biochemistry and Molecular Genetics; Feinberg School of Medicine

Rintaro Hashizume, MD, PhD

Research Program


rintaro.hashizume( at )


Selected Publications

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Cancer-Focused Research

My primary research interests in understanding of the molecular mechanisms, that affect the aggressive/infiltrative biological behavior of malignant brain tumor and would accordingly reveal potential therapeutic targets for cancer therapy. My laboratory employs the latest genomic/epigenomic technologies to identify new therapeutic targets, and test the anti-tumor activity of the therapeutics using patient-derived pediatric brain tumor mouse model system. Our current efforts have been to identify epigenetic targets in pediatric brain tumors. I have a broad background in molecular biology and biochemistry, with specific training and expertise in rodent surgery and xenograft models. I expanded my research to include understanding molecular mechanisms and developing animal model of pediatric brain tumor for pre-clinical testing of molecular targeting therapeutics. As PIor co-Investigator on previous University-and NIH-funded grants, I laid the groundwork for the proposed research by developing suitable animal model of pediatric brain tumors and testing new molecular targeting drugs. In summary, I have a demonstrated record of successful and productive research projects in an area of brain tumor research, and my expertise and experience allow me to investigate and assess the proposed project.