C. David James, PhD
Professor, Neurological Surgery and Biochemistry & Molecular Genetics
The study of molecular, cellular and biological aspects of human cancer. For this purpose, and to explore fundamental questions regarding tumor growth, as well as the effectiveness of therapeutic agents and approaches for treating cancer, I have developed a number of unique model systems, based on the serial propagation of human tumors as subcutaneous xenografts. This approach to tumor cell propagation has been shown to better preserve tumor characteristics, as manifested in patients, than tumor cell propagation in cell culture. In association with the development of these models, my laboratory utilizes numerous techniques to investigate tumor growth and response to novel agents that are administered singularly or in combinations, including with radiation, following xenograft establishment in immunodeficient mice.