Neil Kelleher, PhD
Professor, Biochemistry and Molecular Genetics; Feinberg School of Medicine
- Membranes, Organelles and Metabolism (MOM)
- Hematologic Malignancies (HM)
- Cancer and Physical Sciences (CAPs)
The core of the Kelleher Team is built around expertise in technology development for complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and metabolomics. The Kelleher Research Group has a track record built up involving protein separations, mass spectrometric hardware, and success in software development to harness the value of complex data. Kelleher also harbors specific interests in the use of intact proteins for efficient detection of their post-translational modifications, with specific interests in chromatin and cancer biology, especially the precision analysis of histones and key oncogenes such as P53 and KRas. The Kelleher Research Group develops new ?proteoform-centric? tools for quantitation of protein expression and confident assignment of post-translational modifications using intact proteins (i.e., the ?Top Down? approach) and efficiently translates this frontier approach to Northwestern Investigators on the main campus and at the Feinberg School of Medicine. Neil is also the faculty director of the Proteomics Core, which focuses on the qualitative and quantitative detection of as many cellular components as possible at the protein level. The core emphasizes a philosophy of ?precision proteomics,? which uses high performance mass spectrometry to deliver protein identifications with very high confidence and in a gene-specific fashion.