Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Lou and Jean Malnati Brain Tumor Institute
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Nanoparticles for Delivery of Inhibitory Nucleic Acids

The concept of using nucleic acids, including oligonucleotides and miRNAs, to modulate gene expression in tumor cells has seen extensive research, but successful application has been limited due to nucleic acid instability when administered to animal subjects in the case of preclinical research or to cancer patients in the context of a clinical trial. MBTI investigators have developed nanoparticles that serve to stabilize and deliver nucleic acids to tumor cells, so that the effects of specific nucleic acid sequences can be investigated for anti-tumor activity when used alone as well as when used in combination with other therapeutics.


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