Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Lou and Jean Malnati Brain Tumor Institute
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Increasing Patient Immune Response Against Tumor

Brain tumors are amazing with respect to the mechanisms they use to ensure their growth. One such mechanism involves their release of immune inhibitory substances, while a second involves their expression of cell surface proteins that inhibit immune cell function through contact. MBTI investigators are developing a novel combination therapy to counteract both of these immune suppressive mechanisms by limiting tumor cell synthesis and release of an immune inhibitory substance and by blocking a tumor cell surface protein so that it can no longer inhibit immune cell function through contact. This research is expected to enter clinical trial evaluation in the near future.


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