Northwestern University Feinberg School of Medicine

Asher Center for the Study and Treatment of Depressive Disorders

Dunbar Laboratory for Research on Memory and Fear

The Dunbar Laboratory for Research on Memory and Fear studies the molecular and cellular mechanisms by which memories of stressful events contribute to anxiety- and depression-like behavior. Specifically, our interest lies in neuronal receptors, signal transduction pathways and gene responses mediating:

  1. Formation and extinction of aversive memory

  2. Delayed enhancement of fear memory in the aftermath of stressful experiences

  3. Social modeling of fear

  4. The relationship between aversive memories and depression

We employ molecular biological, biochemical and histological techniques to establish the cells, molecules and brain areas relevant for these processes. Pre-clinical studies with pharmacological and/or genetic mouse models are employed to establish the roles of candidate molecules in fear, anxiety and depression-like behavior. Our long-term goal is to elucidate the key brain mechanisms linking cognitive and emotional processes and identify novel targets for treatment of anxiety and depression.

Our Facilities

Behavioral facilities equipped with: a stereotactic apparatus (Kopf Instruments), MCA microdialysis systems are for adjustable microinjection of drugs; TSE VideoMot2 activity measuring system and apparatuses used for elevated-plus maze, novelty-suppressed feeding, dark-light emergence, and open field forced tests; Two TSE fear conditioning systems for mice are for fear conditioning to context or cues.

Facilities for microscopy equipped with: confocal microscope (Olympus), microtome (Leica 3500S), fluorescent and light microscope (Leica), fluorescent Nikon inverted microscope.

Our Success

Publications

Awards of Field Study Leadership Positions

Jelena Radulovic, MD, PhD, Dunbar Professor of Bipolar Disease, has received several honors and leadership positions throughout her career, including:

Grants and Funding

Lab Staff

Research Assistant Professor

Vladimir Jovasevic PhD, Postdoc

Post-Doctoral Fellows

Ana Cicvaric, PhD

PhD Students

Mariah Meyer (NUIN)
Lynn Renn (NUIN)

Undergraduate Students

Pan Gao

Research Technologist

Viktoriya Grayson, BS
Anna Roessing, MS

Lab Manager

Anita Guedea, MS

Contact Us

Contact Jelena Radulovic, MD, PhD, Dunbar Professor of Bipolar Disease, for more information about the Dunbar Laboratory for Research on Memory and Fear.

Jelena Radulovic
312-503-4627

Lab Alumni

PostDocs

Kevin Corcoran, PhD
Can Gao, PhD
Natalie Tronson, PhD

Visiting Scholars

Yuan Han, PhD
Ivana Mesic, PhD

Graduate Students

Katherine Leaderbrand, PhD
Yomayra Guzman, PhD

Undergraduate Students

Nihmotallahi Adebayo
Medhavi Bhasin, Ba
Helen Chen, Bs
Farzaan Kassam, Bs
Jinha Kim, Bs
Lori Kim, Bs
Ushasi Naha, Bs
Tanvi Patel
Michaela Rente Ritz, Bs

Research Technologist

Cristina Schrick, Bs