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Faculty Profile: Satish N. Nadig, MD, PhD, the Edward G. Elcock Professor of Surgical Research and chief of Organ Transplantation in the Department of Surgery

Satish N. Nadig, MD, PhD, is the Edward G. Elcock Professor of Surgical Research and chief of Organ Transplantation in the Department of Surgery. He also leads the Comprehensive Transplant Center and the Northwestern Memorial Hospital Solid Organ Abdominal Transplant Program. He is an internationally-recognized transplant surgeon and his research focuses on using nanotherapeutic-based targeted drug delivery and immunoregulation to induce organ transplant tolerance and improve solid organ transplantation and patient outcomes.

What are your research interests?

I am interested in novel innovation to induce transplant tolerance. Tolerance is when people don’t have to take harmful immunosuppressive medications to keep their organs from rejecting. I am investigating ways in doing that by using a nanoparticle patented from our lab that houses these antirejection medications in much lower doses and targets the organ of need.

What is the ultimate goal of your research?

The ultimate goal of my research is to get organs to last longer after transplant and for people to be free of the shackles of immunosuppressive medications.

How did you become interested in this area of research?

I have always been interested in the idea of transferring tissues and organs from one person to another and the immunology behind this miracle. I was lucky to have been encouraged by pioneers in the field. Since it is such a young field, these pioneers were also the forefathers of the field.

What types of collaborations are you engaged in across campus and beyond?

I am engaged with collaborations across different institutions, most notably with bioengineers and other clinicians.

How is your research funded?

My research is funded both by the National Institutes of Health and by industry funding. This combination is, in my opinion, the most efficient way to get these technologies where they are needed most: to the patient.

Where have you recently published papers?

I have recently published in the American Journal of Transplantation, our field’s top journal, and the Journal of the American Medical Association (JAMA) and Nature Medicine.

Who inspires you? Who are your mentors?

I am inspired every day by my patients. My career was inspired most notably by Dr. Kathryn Wood, whom I did my PhD under at Oxford University, and Dr. Anthony Monaco, who was a pioneer in the field and one of the forefathers whom I trained under at Beth Israel Deaconess Medical Center at Harvard.