Northwestern University Feinberg School of Medicine
Faculty Profiles
H. William  Schnaper, MD

H. William Schnaper, MD

Associate Chair for Faculty Affairs, Department of Pediatrics

Professor of Pediatrics (Kidney Diseases)

Focus of Work

Bio

William Schnaper received a B.A. in Philosophy from Yale University and his M.D. from University of Maryland, then served as Resident and Chief Resident in Pediatrics at the Mount Sinai Hospital in New York. After two years in the National Health Service Corps he was a Fellow in Pediatric Nephrology at St. Louis Children's Hospital/Washington University, then joined the Faculty there. After 4 years in the extracellular matrix laboratory of Hynda Kleinman at the NIDR, NIH, he joined the Faculty...[Read full text]William Schnaper received a B.A. in Philosophy from Yale University and his M.D. from University of Maryland, then served as Resident and Chief Resident in Pediatrics at the Mount Sinai Hospital in New York. After two years in the National Health Service Corps he was a Fellow in Pediatric Nephrology at St. Louis Children's Hospital/Washington University, then joined the Faculty there. After 4 years in the extracellular matrix laboratory of Hynda Kleinman at the NIDR, NIH, he joined the Faculty in Pediatrics at Northwestern in 1994.[Shorten text]

Academic Focus

We study fibrogenic mechanisms of progressive kidney disease. The Hayashida-Schnaper lab group examines cell phenotype control of fibrogenic responses. Structural, metabolic and environmental factors influence whether renal cells respond to specific stimuli with scar generation. In particular, we study how the molecule, Smad Anchor for Receptor Activation (SARA), maintains epithelial phenotype in a way that makes cells resistant to fibrotic stimuli. For more information on the laboratory's ac...[Read full text]We study fibrogenic mechanisms of progressive kidney disease. The Hayashida-Schnaper lab group examines cell phenotype control of fibrogenic responses. Structural, metabolic and environmental factors influence whether renal cells respond to specific stimuli with scar generation. In particular, we study how the molecule, Smad Anchor for Receptor Activation (SARA), maintains epithelial phenotype in a way that makes cells resistant to fibrotic stimuli. For more information on the laboratory's activities, see the lab URL at http://www.pediatrics.northwestern.edu/research/labs/schnaper/index.html.
My second interest is career development. As Associate Chair, Faculty Development, I support the growth of academic faculty in various activities including Co-director of the Department of Pediatrics Office of Faculty Development, Program Director for the NUCATS Postdoctoral Training Program in Engineering and Pediatrics, and Director of Enrichment Programs for the FSM O'Brien Kidney Research Center.[Shorten text]

Clinical Focus

Dr. Schnaper has studied the clinical manifestations of glomerular disease and the mechanisms by which kidney disease progresses to chronicity and ultimately the need for dialysis and transplantation. A series of events occurs by which (1) the renal response to injury is either inadequate or excessive; (2) a compensatory response by the kidney causes stress to renal structures; (3) adaptive/maladaptive responses occur, altering renal metabolism to cause further stress; and (4) the resulting cyc...[Read full text]Dr. Schnaper has studied the clinical manifestations of glomerular disease and the mechanisms by which kidney disease progresses to chronicity and ultimately the need for dialysis and transplantation. A series of events occurs by which (1) the renal response to injury is either inadequate or excessive; (2) a compensatory response by the kidney causes stress to renal structures; (3) adaptive/maladaptive responses occur, altering renal metabolism to cause further stress; and (4) the resulting cycle of injury and misdirected repair leads inexorably to renal failure.
For information regarding clinical pediatric nephrology at Lurie Children's Hospital, please see the URL at: https://www.luriechildrens.org/en-us/care-services/specialties-services/kidney-diseases/specialists/Pages/index.aspx[Shorten text]

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Education and Certification

  • MD: University of Maryland (1975)
  • Residency: Mt. Sinai Hospital-NY, Pediatrics (1978)
  • Fellowship: Saint Louis Children's Hospital, Pediatrics Nephrology (1982)
  • Board Certification: Pediatric Nephrology, Pediatrics