Praveen Thumbikat, PhD
O'Connor Family Research Professor of Urology
Focus of Work
1. Th1/Th17 mechanisms in chronic pelvic pain: We are interested in understanding the mechanism of T cell mediated pain, the effectors of the pain pathway and measures to modulate Th1/Th17 immune response in animal models and ultimately in humans.
2. Chemokine mechanisms in chronic pelvic pain:We are in the process of identifying the mechanisms that appear to mediate chemokine mediated pelvic pain by focusing both on the prostate as well as on neuronal mechanisms of central sensitization. A further focus of this project is the role of mast cells and mast cell-released intermediates in the pathogenesis of chronic pelvic pain. Identification of biomarkers for CP/CPPS in humans is also an emphasis of this project.
3. Pattern recognition receptors in prostate inflammation: Deficiencies in TLR4 signaling pathways result in increased susceptibility to bacterial infection, and profound defects in innate and adaptive immunity. We are in the process of studying the microbial pathogenesis of prostatic bacterial isolates and dissecting TLR signaling pathways in prostate cells.[Shorten text]
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Education and Certification
- PhD: University of Minnesota, Comparative and Molecular Biosciences (2004)
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