Northwestern University Feinberg School of Medicine

Department of Ophthalmology

Clinical Trials

The Department of Ophthalmology has numerous active clinical trials. Below are a selected list of our current active protocols.

CoordinatorPIStudy Description
Nicole Seddon
nreinhol( at )nm.org
Dr. Angelo TannaCutaneous Prostaglandin Application: Nail Growth, Nail Brittleness, and Eye Pressure - The purpose of the study is to determine if the cutaneous application of a bimatoprost to the proximal nail fold will enhance nail growth and, possibly, reduce nail brittleness.
Nicole Seddon
nreinhol( at )nm.org
Dr. Robert FederA Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Herpes Zoster Keratitis While on Oral Anti-viral Treatment - The purpose of this study is to evaluate the efficacy (defined as the reduction in ulcer size by 90%) of topical ganciclovir 0.15% in treatment of herpes zoster dendritic keratitis.
Nicole Seddon
nreinhol( at )nm.org
Dr. Debra GoldsteinClearside 201: A Randomized, Masked, Multicenter Study to Assess the Safety and Efficacy of CLS-TA, Triamcinolone Acetonide Injectable Suspension in the Treatment of Subjects with Macular Edema Following Uveitis - The purpose of this study is to evaluate the safety and efficacy of CLS-TA in subjects with ME following non-infectious uveitis. Two different doses, 4 mg and 0.8 mg, of CLS-TA will each be evaluated for safety and efficacy.
Nicole Seddon
nreinhol( at )nm.org
Dr. Manjot K. GillCAPELLA: A Phase 2, Double-Masked, Randomized, Controlled, Multiple-Dose, Regimen-Ranging Study of the Efficacy and Safety of Intravitreal REGN2176-3 in Patients with Neovascular Age-Related Macular Degeneration - The purpose of the study is to explore the effect of REGN2176-3 on the Early Treatment Diabetic Retinopathy Scale (ETDRS) best corrected visual acuity (BCVA) in patients with neovascular age-related macular degeneration (AMD), compared to intravitreal aflibercept injection (IAI) monotherapy.
Carmen Ramirez
carmen.ramirez( at )nm.org
Dr. Lee M. Jampol (CODA) MOLECULAR GENETIC APPROACHES IN CELL BIOLOGY STUDIES OF CAVITARY OPTIC DISC ANOMALY (CODA) - The purpose of this study is to understand the genetic characteristics of patients and their family members who have been diagnosed with cavitary optic disk anomalies (CODA).  Skin biopsy and blood specimens will be tested for known and candidate genes that are linked to CODA.  The skin cells from the biopsy will be turned into stem cells that can be grown in order to do a variety of genetic tests to examine genes that may be related to CODA.  These stem cells will be kept indefinitely.
Lucius Robinson III
r-lucius( at )northwestern.edu
Dr. Surendra Basti

Prospective randomized evaluation of centration of intraocular lens with two laser settings for capsulorhexis with femtosecond laser - The purpose of this study is to compare the results of two different ways of doing a step of the laser cataract surgery called capsulorhexis. The human cataract is like a cellophane bag (lens capsular bag) that is filled with a cloudy gel. During cataract surgery, the front surface of the cellophane bag has to be opened in a circular fashion. This step is called continuous curvilinear capsulorhexis (CCC). It is believed that placing the CCC in the middle of the bag (and on its front surface) is best. But, knowing where the middle of the bag is can be challenging. Many surgeons place it in the middle of the pupil (pupil centration). Others believe that it should be centered on the scanned image (obtained by the laser during surgery) of the capsular bag (scanned capsule centration). In this study, we will compare the outcomes of two ways of centering the CCC on the front of the capsule – pupil centration or scanned capsule centration.

Lucius Robinson III
r-lucius( at )northwestern.edu
Dr. Rukhsana MirzaSafety and Efficacy of Abicipar Pegol (AGN-150998) in Patients with Neovascular Age-related Macular Degeneration - the purpose of the study is to assess the safety and efficacy of abicipar compared with ranibizumab in treatment-naïve patients withneovascular age-related macular degeneration (AMD)
Julie Johnson
j-johnson( at )northwestern.edu
Alice T. Lyon, MDDiabetic Retinopathy Clinical Study - The objective of the network is to evaluate promising new treatment approaches for diabetic retinopathy. The goal of the DRCR network is to provide a framework for consistency in performing research related to ocular complications of diabetes. All centers participating will be following the same standardized procedures for visual acuity testing, fundus photography, fluorescein angiography, optical coherence tomography, and other procedures that might be performed as part of the research. Some of the individually approved projects are treatment studies, while others are observational in nature and consist of different tests to obtain information about the ocular complications of diabetes.