Northwestern University Feinberg School of Medicine

Department of Microbiology-Immunology

Hyewon  Phee, PhD

Hyewon Phee, PhD

Adjunct Assistant Professor of Microbiology-Immunology

Focus of Work

Bio

Chemokine and antigen stimulation activates multiple signaling networks to reorganize cytoskeletal systems to ensure proper migration and activation of T lymphocytes. There is increasing evidence that activators and regulators of cytoskeletal systems are critical for coordinating T cell migration and activation. However, which molecular machinery links signaling inputs from various receptors to cytoskeletal system to coordinate T cell activation and migration is incompletely understood. Our long...[Read full text]Chemokine and antigen stimulation activates multiple signaling networks to reorganize cytoskeletal systems to ensure proper migration and activation of T lymphocytes. There is increasing evidence that activators and regulators of cytoskeletal systems are critical for coordinating T cell migration and activation. However, which molecular machinery links signaling inputs from various receptors to cytoskeletal system to coordinate T cell activation and migration is incompletely understood. Our long-term research goal is to define signal transduction pathways that integrate cytoskeleton and signaling network during immune cell migration and activation in normal and pathological conditions.

Our current research focuses on one of the critical signaling pathways that are activated upon T cell receptor and chemokine receptor engagement. More specifically, we are interested in the pathway that activates PAK (p21-activated kinases) and their binding partners, GIT (G protein-coupled receptor kinase-interacting target) and PIX (PAK interacting exchange factor). Although this pathway is thought to play an important role in T cell activation and cytoskeletal dynamics and eventually generate productive immune responses, the exact function and activation mechanism are not clear. To determine the role and activation mechanism of the PAK2-PIX-GIT pathway in immune system, we combine genetic, molecular, biochemical and two-photon microscopic approaches. Two main areas of our research are; (1) Determine the role of GIT2 in T cell migration and effector T cell function; (2) Define the role of PAK2 in T cell activation and migration.[Shorten text]

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Education and Certification

  • PhD: Ohio State University, Biochemistry (2001)

Contact

312-503-5240

Tarry Building Room 6-733
300 E Superior
Chicago IL 60611