Using Mouse Models to Study the Pathogenesis and Immune Response to Zika Virus: Michael Diamond, MD, PhD

Microbiology-Immunology Seminar Series


Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. Concomitant with its recent spread to countries in the Western Hemisphere, which was associated with reports of microcephaly, congenital malformations and Guillain-Barré syndrome, the pace of discovery of ZIKV biology has accelerated greatly. Within a short time period, we and others have established useful mouse and non-human primate disease models, and pre-clinical evaluation of therapeutics and vaccines has begun. Unexpectedly, ZIKV exhibits a broad tropism and persistence in body tissues and fluids, which contributes to the clinical manifestations and epidemiology that have been observed during the current epidemic. In this talk, I will focus on studies from my laboratory that generated mouse models of ZIKV infection and pathogenesis during pregnancy as well as in the male reproductive tract. I will cover the effects of gestational age on ZIKV pathogenesis in utero, analysis of tropism, and discuss novel approaches for counter-measures including therapeutic antibodies and vaccines.


Michael S. Diamond, MD, PhD

Washington University School of Medicine

Host: M-I Dept. Virology Graduate Students

Coordinator: Mark Manzano, Graduate Student





Virology Journal Club: Rick Soora (Longnecker Lab) & Ajinkya Patil (Gottwein Lab)

Virologists from NU meet every week to discuss their research in porgress and new virology publications.  



Mechanisms and Inhibition of HIV-1 Integration: Alan N. Engelman, PhD

Microbiology-Immunology Seminar Series

AIDS is incurable due to the stable integration of HIV DNA into cellular chromatin. Integrase, the responsible enzyme, is a high value antiviral target. Dr. Engelman`s research has helped uncover the structural basis of HIV DNA integration, as well as the mechanism of action of the clinical integrase inhibitors. He has additionally characterized a new class of integrase inhibitor that unexpectedly inhibits HIV particle maturation.


Alan Engelman, PhD

Harvard Medical School

Host: Mojgan Naghavi, PhD



Virology Club: Dr. Mark Manzano

"Functional Genomics Reveal Oncogenic Mechanisms of KSHV-transformed Primary Effusion Lymphoma Cell Lines"

Mark Manzano, PhD. Gottwein Lab. Northwestern University.



Virology Journal Club: Ryan Hong (Laimins Lab)

Virologists from NU meet every week to discuss their research in progress and new virology publications.



Discovering and Engineering Antibodies to Treat Viral and Bacterial Infections: Man-Wah Tan, PhD

Microbiology-Immunology Seminar Series

The seminar will discuss the discovery of broadly neutralizing antibodies for the treatment of severe influenza infections and the engineering of a antibody-antibotic conjugate to treat severe S. aureus bacteremia.

Man-Wah Tan, PhD

Director, Infectious Diseases Department, Genentech Inc.

Host; Alan Hauser MD, PhD




The Good and the Bad: Two Faces of Microbiota in the Eye: Rachel R. Caspi, PhD

Microbiology-Immunology Seminar Series

The commensal microbiome affects affects immunity and immune mediated disease locally as well as in distal sites. Microbiota can play very different roles in inflammatory disease affecting the eye, depending on the context and the location. Our data suggest that intestinal microbiota can serve as a source of crossreactive antigenic material that activates retina-specific T cells that happen to migrate through the gut, and endow them with the ability to cross the blood-retinal barrier and fuel autoimmune disease in the eye. On the other hand, microbiota on the surface of the eye may play a positive role in local host defense, by tuning immune function in the ocular surface mucosa.

Rachel Caspi, PhD

Chief, Immunoregulation Section
Acting Chief, Lab. Immunol., NEI, NIH

Host: Melissa Brown, PhD



TBA: Patrick Seed, PhD

Microbiology-Immunology Seminar Series




Patrick Seed, PhD

Northwestern University

Host:  Dr. Laimonis Laimins



Virology Club: Dr. Michael “Keegan” Delaney

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Michael “Keegan” Delaney, Ph.D. Naghavi Lab. Northwestern University.



TBA: Theodora Hatziioannou, PhD

Microbiology-Immunology Seminar Series




Theodora Hatziioannou, PhD

Aaron Diamond AIDS Research Center

Host: Eva Gottwein, PhD




Molecular Mechanisms of Varicella-zoster Virus Pathogenesis: Ann M. Arvin, MD

Patricia A. Spear Colloquium

Microbiology-Immunology Seminar Series

 Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and establishes latency in sensory ganglion neurons; VZV reactivation results in herpes zoster. The formation of polykaryocytes, induced by cell-cell fusion between fully differentiated host cells within the tissue microenvironment, is a hallmark of VZV pathogenesis in skin and ganglia. Analyzing the molecular mechanisms of VZV pathogenesis in the severe combined immunodeficiency mouse (SCID) model reveals the critical role of the glycoproteins gB and gH/gL in this process. VZV pathogenesis also depends on its tropism for T cells to support viral transport to skin, which is promoted by its capacity to trigger the phenotypic remodeling of both naïve and memory T cells.


Ann M. Arvin, MD

Stanford University

Host: Richard Longnecker, PhD