Northwestern University Feinberg School of Medicine

Institute for Public Health and Medicine

Northwestern Launches Center for Prevention and Treatment of Rheumatic and Musculoskeletal Conditions

A new five-year grant from the National Institutes of Health (NIH) will provide infrastructure to scientists and investigators at Northwestern University to support, accelerate, and improve the quality and impact of clinical research aimed at preventing or treating rheumatic and musculoskeletal conditions.

The funding, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports the creation of the Core Center for Clinical Research at Northwestern University (CCCR). NIAMS created this grant specifically to condense the time between an investigator conceiving of a way to prevent or treat someone with rheumatic or musculoskeletal conditions and that intervention being incorporated into patient and population care. Rheumatic conditions include osteoarthritis, rheumatoid arthritis, other types of arthritis, lupus, systemic sclerosis/scleroderma, and vasculitis. Musculoskeletal conditions include any conditions that affect the joints, bones, muscles, ligaments, tendons, and injury to these tissues. 

Improving how people feel and function in their daily lives

Specifically, under the leadership of PI Leena Sharma and Coinvestigators Michael Bass, C. Hendricks Brown, Rowland W. Chang, Joan S. Chmiel, Dorothy Dunlop, Hassan Ghomrawi, Monique Hinchcliff, Kristi L. Holmes, Masha Kocherginsky, Julia Lee, David C. Mohr, Richard Pope, Rosalind Ramsey-Goldman, Nan Rothrock, Bonnie Spring, Linda Van Horn, and Deborah Winter, the CCCR’s work will focus on prevention strategy and intervention development to create lifestyle, behavioral, medical, and rehabilitative solutions for individuals with or at risk for these conditions. These conditions affect a very large segment of the U.S. population. For example, an estimated 21 million Americans have diagnosed osteoarthritis, just one of the conditions that the CCCR targets. Considering just the knee, among Americans 55 years and older, 40% have frequent knee pain or radiographic knee osteoarthritis. In older individuals, knee osteoarthritis is responsible for as much chronic disability as cardiovascular disease.

The Center will support studies of persons throughout the lifespan, from childhood through old age, with the overarching goal of improving outcomes for those persons at risk for these conditions or who are already afflicted.

Providing research support to all collaborators

The overall aims of the CCCR are as follows:

  1. Accelerate and enhance funded research, by improving efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact – this Aim deals with already funded research at Northwestern
  2. Catalyze and add value to all NU research relevant to our mission – this Aim also deals with work that is already planned or underway
  3. Promote new research, by expanding the community working in the areas of our mission and by expanding research fields within the mission – this Aim deals with work that has not as yet been envisioned

The CCCR is comprised of Administrative, Methodologic, and Resource Cores:

The CCCR is funded by NIH NIAMS grant P30AR072579. The Center will operate as an integrated unit, drawing on many outstanding departments and divisions across Northwestern’s Feinberg School of Medicine: the Departments of Medicine, Preventive Medicine, Medical Social Sciences, Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, the Institute for Public Health and Medicine (IPHAM), and the Northwestern University Clinical and Translational Sciences Institute (NUCATS).

Congratulations to the Northwestern CCCR team!