Read the latest news from Northwestern University Feinberg School of Medicine’s Center for Diabetes and Metabolism. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards, and honors.
The time of day you hit the gym could have an impact on the quality of your workout, according to researchpublished in the October 2016 issue of Cell Metabolism.Researchers discovered circadian clocks in the muscle tissue that regulate how well it adapts to changes in the environment and activities throughout a 24-hour period. “Our sleep/wake cycle is programmed by our internal biological clock,” says lead researcher Joe Bass, MD, PhD, the chief of the Division of Endocrinology, Metabolism and Molecular Medicine at the Feinberg School of Medicine at Northwestern University. “There is a similar clock in the muscle tissue.”
Not So Sweet: Getting smart about sugar
Most of us are guilty of indulging in sugary foods and beverages over the holiday season. But with the new year, now is the time to get on track with your sugar intake. Knowing where to spot sugar is the first step. “The first thing that everybody needs to figure out is where the sugar is in their diet,” says Lisa Neff, MD, an endocrinologist at the Center for Lifestyle Medicine at Northwestern Memorial Hospital. Some sources of sugar are more obvious (think cookies, cake and ice cream), but others are well hidden.
The time of day determines a muscle's energy efficiency and metabolic response.
Northwestern Medicine scientists have discovered circadian clocks in muscle tissue that control the muscle's metabolic response and energy efficiency depending on the time of day. The finding in mice sheds light on the time-of-day differences in muscle's ability to adapt to exercise and use oxygen for energy. Muscle cells are more efficient during an organism's normal waking hours, the study found. All cells in the body, including those in muscle, contain a clock that regulates how cells adapt to changes in the environment and activity across the 24-hour day. "Oxygen and the internal clock are doing a dance together inside muscle cells to produce energy, and the time of day determines how well that dance is synchronized," said senior author Dr. Joseph Bass. "The capacity for a cell to perform its most important functions, to contract, will vary according to the time of day. More research is needed before the finding can be translated into workout advice.
Northwestern Medicine scientists have detected circadian clocks in flesh hankie that control a muscle’s metabolic response and appetite potency depending on a time of day. The anticipating in mice sheds light on a time-of-day differences in muscle’s ability to adjust to practice and use oxygen for energy. Muscle cells are some-more fit during an organism’s normal waking hours, a investigate found. All cells in a body, including those in muscle, enclose a time that regulates how cells adjust to changes in a sourroundings and activity opposite a 24-hour day. “Oxygen and a middle time are doing a dance together inside flesh cells to furnish energy, and a time of day determines how good that dance is synchronized,” pronounced comparison author Dr. Joseph Bass. “The ability for a dungeon to perform a many vicious functions, to contract, will change according to a time of day."