The Center for Translational Metabolism and Health currently studies the impact of phosphate and fibroblast growth factor 23 (FGF23) biology on health and disease. CTMH investigators span the spectrum of molecular biology, animal models, therapeutic target discovery, physiologic patient-oriented investigation, epidemiology, genetics, clinical trials, health disparities, health policy, and health services research.
The CTMH aims to create an environment committed to discovery and scholarship. Learn more about our work below.
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Investigating disordered mineral metabolism related to vitamin D and fibroblast growth factor-23 in childhood conditions including pediatric chronic kidney disease and obesity.
Molecular mechanisms of metabolic bone diseases, with particular emphasis on the regulation and function of FGF23 in situations of normal and abnormal mineral metabolism.
Specializing in disordered mineral metabolism in chronic kidney disease; supporting a multi-center study testing the biochemical efficacy and safety of phospates and FGF-23-lowering interventions in patients with stage 3-4 chronic kidney disease.
The Martin Lab investigates the role of the skeleton in the endocrine regulation of mineral metabolism and the cardiovascular complications of mineral and bone diseases.
Investigating disordered phosphate homeostasis and the pathogenesis of microvascular disease in chronic kidney disease.
Investigating novel markers of chronic kidney disease and acute kidney injury to identify and evaluate better methods to phenotype kidney diseases.
Defining novel mechanisms of disease that can be targeted in randomized trials aimed at improving clinical outcomes among individuals with kidney disease.
Mentoring physician-scientist and PhD talent in translational research is a CTMH priority. A diverse array of trainees with broad backgrounds is welcome. Contactto learn more.