Focus of Work
Over a decade of research had identified the kinetochore-bound Ndc80 complex as the key requirement for the direct physical contact with microtubules of the spindle. But what is still not understood well is how the kinetochores and the Ndc80 complex remains stably attached to the highly dynamic microtubule plus-ends during mitotic metaphase and subsequent chromosome segregation in anaphase. Work is yeast model system had provided us with important insights into the possible mechanism governing this process, but we still do not have a clear mechanistic picture in vertebrate systems. Work in my lab focusses on understanding the molecular mechanisms that are involved the controlling and regulating kinetochore microtubule attachments in vertebrate cells. We are also very interested to delineate the intricate mechanism that link this event with the activation and silencing of the spindle assembly checkpoint which is also absolutely critical for accurate chromosome segregation.[Shorten text]
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Education and Certification
- PhD: Columbia College of Physicians and Surgeons, Cell Biology (2008)
- Postdoctoral Fellowship: University of North Carolina, Biology/Biochemistry and Biophysics (2014)
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Northwestern University Feinberg School of Medicine
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Institutes and Centers
Visit Dileep Varma's Northwestern Scholars Profile to see the list of publications.